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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA

Authors:
Price AM, Steinbock RT, Di C, Hayer KE, Li Y, Herrmann C, Parenti NA, Whelan JN, Weiss SR, Weitzman MD
Citation:
Nucl Acids Res. 2021;[Epub]:gkab896. doi:10.1093/nar/gkab896
Epub:
Yes
Abstract:
Eukaryotic cells recognize intracellular pathogens through pattern recognition receptors, including sensors of aberrant nucleic...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab896/6406474
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
cell culture: A549
Citation Extract:
Price AM, Steinbock RT, Di C, Hayer KE, Li Y, Herrmann C, Parenti NA, Whelan JN, Weiss SR, Weitzman MD. Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA. Nucl Acids Res. 2021;[Epub]:gkab896. doi:10.1093/nar/gkab896.

Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice

Authors:
Mukashyaka MC, Wu CL, Ha K, Zhang J, Wood J, Foley S, Mastis B, Jungels N, Sun H, Shadid M, Harriman S, Hadcock JR
Citation:
Pharm Res. 2021 Oct 20. doi: 10.1007/s11095-021-03118-5. Online ahead of print
Epub:
Yes
Abstract:
Purpose: Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) have shown promise in treating Duchenne muscular...
Link:
https://link.springer.com/article/10.1007%2Fs11095-021-03118-5
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Mukashyaka MC, Wu CL, Ha K, Zhang J, Wood J, Foley S, Mastis B, Jungels N, Sun H, Shadid M, Harriman S, Hadcock JR. Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice. Pharm Res. 2021 Oct 20. doi: 10.1007/s11095-021-03118-5. Online ahead of print.

An in vitro system to silence mitochondrial gene expression

Authors:
Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P
Citation:
Cell. 2021;[Epub ahead of print] doi:10.1016/j.cell.2021.09.033
Epub:
Not Epub
Abstract:
The human mitochondrial genome encodes thirteen core subunits of the oxidative phosphorylation system, and defects in...
Link:
https://www.sciencedirect.com/science/article/pii/S0092867421011168
Organism or Cell Type:
cell culture: isolated mitochondria
Citation Extract:
Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P. An in vitro system to silence mitochondrial gene expression. Cell. 2021;[Epub ahead of print] doi:10.1016/j.cell.2021.09.033.

The Proapoptotic Gene Bad Regulates Brain Development via P53-Mediated Stress Signals in Zebrafish

Authors:
Hung J-C, Wu J-L, Li H-C, Chiu H-W, Hong J-R
Citation:
Cells. 2021;10(11):2820. doi:10.3390/cells10112820
Epub:
Not Epub
Abstract:
Studies have shown that the BH3-only domain Bad regulates brain development via the control of programmed cell death (PCD), but...
Link:
https://www.mdpi.com/2073-4409/10/11/2820
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hung J-C, Wu J-L, Li H-C, Chiu H-W, Hong J-R. The Proapoptotic Gene Bad Regulates Brain Development via P53-Mediated Stress Signals in Zebrafish. Cells. 2021;10(11):2820. doi:10.3390/cells10112820.

Genetic landscape of T cells identifies synthetic lethality for T-ALL

Authors:
O’Meara CP, Guerri L, Lawir D-F, Mateos F, Iconomou M, Iwanami N, Soza-Ried C, Sikora K, Siamishi I, Giorgetti O, Peter S, Schorpp M, Boehm T
Citation:
Comm Biol. 2021;4(1):1201. doi:10.1038/s42003-021-02694-x
Epub:
Not Epub
Abstract:
To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale...
Link:
https://www.nature.com/articles/s42003-021-02694-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
O’Meara CP, Guerri L, Lawir D-F, Mateos F, Iconomou M, Iwanami N, Soza-Ried C, Sikora K, Siamishi I, Giorgetti O, Peter S, Schorpp M, Boehm T. Genetic landscape of T cells identifies synthetic lethality for T-ALL. Comm Biol. 2021;4(1):1201. doi:10.1038/s42003-021-02694-x.

V-type H+ ATPase Activity is Required for Embryonic Dorsal-Ventral Symmetry Breaking

Authors:
Schatzberg D, Thomas CF, Reidy P, Hadyniak SE, Skidanova V, Lawton ML, Dojer L, Kitchloo S, Zuch DT, Bradham CA
Citation:
bioRxiv. 2021;[preprint]. doi:10.1101/2021.10.18.464707
Epub:
Not Epub
Abstract:
The mechanism for embryonic dorsal-ventral (DV) symmetry breaking is idiosyncratic to the species, then converges on polarized...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.18.464707v1
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus (sea urchin)
Citation Extract:
Schatzberg D, Thomas CF, Reidy P, Hadyniak SE, Skidanova V, Lawton ML, Dojer L, Kitchloo S, Zuch DT, Bradham CA. V-type H+ ATPase Activity is Required for Embryonic Dorsal-Ventral Symmetry Breaking. bioRxiv. 2021;[preprint]. doi:10.1101/2021.10.18.464707.

Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis

Authors:
Pradhan SJ, Reddy PC, Smutny M, Sharma A, Sako K, Oak MS, Shah R, Pal M, Deshpande O, Dsilva G, Tang Y, Mishra R, Deshpande G, Giraldez AJ, Sonawane M, Heisenberg C-P, Galande S
Citation:
Nat Commun. 2021;12(1):6094. doi:10.1038/s41467-021-26234-7
Epub:
Not Epub
Abstract:
Zygotic genome activation (ZGA) initiates regionalized transcription underlying distinct cellular identities. ZGA is dependent...
Link:
https://www.nature.com/articles/s41467-021-26234-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pradhan SJ, Reddy PC, Smutny M, Sharma A, Sako K, Oak MS, Shah R, Pal M, Deshpande O, Dsilva G, Tang Y, Mishra R, Deshpande G, Giraldez AJ, Sonawane M, Heisenberg C-P, Galande S. Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nat Commun. 2021;12(1):6094. doi:10.1038/s41467-021-26234-7.

NAMPT reduction-induced NAD+ insufficiency contributes to the compromised oocyte quality from obese mice

Authors:
Wang H, Zhu S, Wu X, Liu Y, Ge J, Wang Q, Gu L
Citation:
Aging Cell. 2021 Oct 18:e13496. doi: 10.1111/acel.13496. Online ahead of print
Epub:
Not Epub
Abstract:
Maternal obesity is associated with multiple adverse reproductive outcomes, whereas the underlying molecular mechanisms are...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/acel.13496
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Wang H, Zhu S, Wu X, Liu Y, Ge J, Wang Q, Gu L. NAMPT reduction-induced NAD+ insufficiency contributes to the compromised oocyte quality from obese mice. Aging Cell. 2021 Oct 18:e13496. doi: 10.1111/acel.13496. Online ahead of print.

Mutated VWA8 Is Associated With Developmental Delay, Microcephaly, and Scoliosis and Plays a Novel Role in Early Development and Skeletal Morphogenesis in Zebrafish

Authors:
Umair M, Farooq Khan M, Aldrees M, Nashabat M, Alhamoudi KM, Bilal M, Alyafee Y, Al Tuwaijri A, Aldarwish M, Al-Rumayyan A, Alkhalaf H, Wadaan MAM, Alfadhel M
Citation:
Front Cell Dev Biol. 2021 Oct 1;9:736960. doi: 10.3389/fcell.2021.736960. eCollection 2021
Epub:
Not Epub
Abstract:
Von Willebrand A domain-containing protein 8 (VWA8), also named KIAA0564, is a poorly characterized, mitochondrial matrix-...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2021.736960/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Umair M, Farooq Khan M, Aldrees M, Nashabat M, Alhamoudi KM, Bilal M, Alyafee Y, Al Tuwaijri A, Aldarwish M, Al-Rumayyan A, Alkhalaf H, Wadaan MAM, Alfadhel M. Mutated VWA8 Is Associated With Developmental Delay, Microcephaly, and Scoliosis and Plays a Novel Role in Early Development and Skeletal Morphogenesis in Zebrafish. Front Cell Dev Biol. 2021 Oct 1;9:736960. doi: 10.3389/fcell.2021.736960. eCollection 2021.

Nucleolin loss-of-function leads to aberrant FGF signaling and craniofacial anomalies

Authors:
Dash S, Trainor PA
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.14.460382
Epub:
Not Epub
Abstract:
rRNA transcription and ribosome biogenesis are global processes required for growth and proliferation of all cells, yet...
Link:
https://www.biorxiv.org/content/10.1101/2021.09.14.460382v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dash S, Trainor PA. Nucleolin loss-of-function leads to aberrant FGF signaling and craniofacial anomalies. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.14.460382.

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