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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Authors:
Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Phadke K-S, Zhang G, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Verhoeven DE, Pentelute BL
Citation:
Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4
Epub:
Not Epub
Abstract:
Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine...
Link:
https://www.nature.com/articles/s41467-021-24598-4
Delivery Method:
cell bathing
Organism or Cell Type:
cell culture: Vero-E6 & SARS-CoV-2
Citation Extract:
Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Phadke K-S, Zhang G, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Verhoeven DE, Pentelute BL. Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers. Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4.

Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations

Authors:
Qi H, Schmöhl F, Li X, Qian X, Tabler CT, Bennewitz K, Sticht C, Morgenstern J, Fleming T, Volk N, Hausser I, Heidenreich E, Hell R, Nawroth PP, Kroll J
Citation:
Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281
Epub:
Not Epub
Abstract:
Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202101281
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Qi H, Schmöhl F, Li X, Qian X, Tabler CT, Bennewitz K, Sticht C, Morgenstern J, Fleming T, Volk N, Hausser I, Heidenreich E, Hell R, Nawroth PP, Kroll J. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281.

Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae

Authors:
Lin CH, Hu HJ, Chuang HJ, Tsou YL, Hwang PP
Citation:
J Comp Physiol B. 2021 Jul 17. doi: 10.1007/s00360-021-01390-w. Online ahead of print
Epub:
Not Epub
Abstract:
Freshwater fish live in environments where pH levels fluctuate more than those in seawater. During acidic stress, the acid-base...
Link:
https://link.springer.com/article/10.1007%2Fs00360-021-01390-w
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Lin CH, Hu HJ, Chuang HJ, Tsou YL, Hwang PP. Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae. J Comp Physiol B. 2021 Jul 17. doi: 10.1007/s00360-021-01390-w. Online ahead of print.

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

Authors:
Boeckel J-N, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B
Citation:
Genomics Proteomics Bioinformatics. 2021;[Epub ahead of print] doi:10.1016/j.gpb.2021.01.006
Epub:
Yes
Abstract:
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing...
Link:
https://www.sciencedirect.com/science/article/pii/S1672022921001467
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boeckel J-N, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B. SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy. Genomics Proteomics Bioinformatics. 2021;[Epub ahead of print] doi:10.1016/j.gpb.2021.01.006.

The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis

Authors:
DeJong CS, Dichmann DS, Exner CRT, Xu Y, Harland RM
Citation:
Development. 2021 Aug 1;148(15):dev191619. doi: 10.1242/dev.191619. Epub 2021 Aug 4. PMID: 34345915; PMCID: PMC8353262
Epub:
Not Epub
Abstract:
The FET family of atypical RNA-binding proteins includes Fused in sarcoma (FUS), Ewing's sarcoma (EWS) and the TATA-...
Link:
https://journals.biologists.com/dev/article/148/15/dev191619/271175/The-atypical-RNA-binding-protein-Taf15-regulates
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
DeJong CS, Dichmann DS, Exner CRT, Xu Y, Harland RM. The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis. Development. 2021 Aug 1;148(15):dev191619. doi: 10.1242/dev.191619. Epub 2021 Aug 4. PMID: 34345915; PMCID: PMC8353262.

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Authors:
Thomas C, Wetherall B, Levasseur D, Harris RJ, Kerridge ST, Higgins JMG, Davies OR, Madgwick S
Citation:
Nat Commun. 2021;12(1):4322. doi:10.1038/s41467-021-24554-2
Epub:
Not Epub
Abstract:
Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase,...
Link:
https://www.nature.com/articles/s41467-021-24554-2
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Thomas C, Wetherall B, Levasseur D, Harris RJ, Kerridge ST, Higgins JMG, Davies OR, Madgwick S. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes. Nat Commun. 2021;12(1):4322. doi:10.1038/s41467-021-24554-2.

Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2

Authors:
Balaraju AK, Hu B, Rodriguez JJ, Murry M, Lin F
Citation:
Development. 2021 Jul 15;148(14):dev199421. doi: 10.1242/dev.199421. Epub 2021 Jul 12
Epub:
Not Epub
Abstract:
Noncanonical Wnt/planar cell polarity (Wnt/PCP) signaling has been implicated in endoderm morphogenesis. However, the...
Link:
https://journals.biologists.com/dev/article-abstract/148/14/dev199421/270869/Glypican-4-regulates-planar-cell-polarity-of
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Balaraju AK, Hu B, Rodriguez JJ, Murry M, Lin F. Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2. Development. 2021 Jul 15;148(14):dev199421. doi: 10.1242/dev.199421. Epub 2021 Jul 12.

Rab7 is required for mesoderm patterning and gastrulation in Xenopus

Authors:
Kreis J, Wielath FM, Vick P
Citation:
Biol Open. 2021 Jul 15;10(7):bio056887. doi: 10.1242/bio.056887. Epub 2021 Jul 12
Epub:
Not Epub
Abstract:
Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling....
Link:
https://journals.biologists.com/bio/article/10/7/bio056887/270868/Rab7-is-required-for-mesoderm-patterning-and
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kreis J, Wielath FM, Vick P. Rab7 is required for mesoderm patterning and gastrulation in Xenopus. Biol Open. 2021 Jul 15;10(7):bio056887. doi: 10.1242/bio.056887. Epub 2021 Jul 12.

Pten associates with important gene regulatory network to fine-tune Müller glia-mediated zebrafish retina regeneration

Authors:
Gupta S, Sharma P, Chaudhary M, Premraj S, Kaur S, Vijayan V, Arun MG, Prasad NG, Ramachandran R
Citation:
Glia. 2023 Feb;71(2):259-283. doi: 10.1002/glia.24270. Epub 2022 Sep 21. PMID: 36128720
Epub:
Not Epub
Abstract:
Unlike mammals, zebrafish possess a remarkable ability to regenerate damaged retina after an acute injury. Retina regeneration...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/glia.24270
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gupta S, Sharma P, Chaudhary M, Premraj S, Kaur S, Vijayan V, Arun MG, Prasad NG, Ramachandran R. Pten associates with important gene regulatory network to fine-tune Müller glia-mediated zebrafish retina regeneration. Glia. 2023 Feb;71(2):259-283. doi: 10.1002/glia.24270. Epub 2022 Sep 21. PMID: 36128720.

Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis

Authors:
Djenoune L, Tomar R, Dorison A, Ghobrial I, Schenk H, Hegermann J, Beverly-Staggs L, Hidalgo-Gonzalez A, Little MH, Drummond IA
Citation:
J Am Soc Nephrol. 2021 Apr 28:ASN.2020101525. doi: 10.1681/ASN.2020101525. Online ahead of print
Epub:
Yes
Abstract:
Background: Podocytes are critical to maintaining the glomerular filtration barrier, and mutations in nephrotic syndrome genes...
Link:
https://jasn.asnjournals.org/content/32/7/1697
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Djenoune L, Tomar R, Dorison A, Ghobrial I, Schenk H, Hegermann J, Beverly-Staggs L, Hidalgo-Gonzalez A, Little MH, Drummond IA. Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis. J Am Soc Nephrol. 2021 Apr 28:ASN.2020101525. doi: 10.1681/ASN.2020101525. Online ahead of print.

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