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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12165 scientific papers returned from the database with the search filters currently being used below.

Synaptotagmin 1 regulates cortical granule exocytosis during mouse oocyte activation

Authors:
Zhu XL, Li SF, Zhang XQ, Xu H, Luo YQ, Yi YH, Lv LJ, Zhang CH, Wang ZB, Ouyang YC, Hou Y, Schatten H, Liu FH
Citation:
Zygote. 2019 Dec 2:1-6. doi: 10.1017/S0967199419000704. [Epub ahead of print]
Epub:
Yes
Abstract:
Synaptotagmin 1 (Syt1) is an abundant and important presynaptic vesicle protein that binds Ca2+ for the regulation of synaptic...
Link:
https://www.cambridge.org/core/journals/zygote/article/synaptotagmin-1-regulates-cortical-granule-exocytosis-during-mouse-oocyte-activation/5405692ACFC2A162759657EAEC76C815
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhu XL, Li SF, Zhang XQ, Xu H, Luo YQ, Yi YH, Lv LJ, Zhang CH, Wang ZB, Ouyang YC, Hou Y, Schatten H, Liu FH. Synaptotagmin 1 regulates cortical granule exocytosis during mouse oocyte activation. Zygote. 2019 Dec 2:1-6. doi: 10.1017/S0967199419000704. [Epub ahead of print].

Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a

Authors:
Palasin K, Uechi T, Yoshihama M, Srisowanna N, Choijookhuu N, Hishikawa Y, Kenmochi N, Chotigeat W
Citation:
Sci Rep. 2019 Dec 2;9(1):18130. doi: 10.1038/s41598-019-54544-w
Epub:
Not Epub
Abstract:
In this study, to investigate the secondary function of Rpl10a in zebrafish development, morpholino antisense oligonucleotides...
Link:
https://www.nature.com/articles/s41598-019-54544-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Palasin K, Uechi T, Yoshihama M, Srisowanna N, Choijookhuu N, Hishikawa Y, Kenmochi N, Chotigeat W. Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a. Sci Rep. 2019 Dec 2;9(1):18130. doi: 10.1038/s41598-019-54544-w.

Cell-fate plasticity, adhesion and cell sorting complementarily establish a sharp midbrain-hindbrain boundary

Authors:
Kesavan G, Machate A, Hans S, Brand M
Citation:
Development. 2020 Jun 8;147(11):dev186882. doi: 10.1242/dev.186882. PMID: 32439756
Epub:
Not Epub
Abstract:
The formation and maintenance of sharp boundaries between groups of cells play a vital role during embryonic development as...
Link:
https://journals.biologists.com/dev/article/147/11/dev186882/225315/Cell-fate-plasticity-adhesion-and-cell-sorting
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kesavan G, Machate A, Hans S, Brand M. Cell-fate plasticity, adhesion and cell sorting complementarily establish a sharp midbrain-hindbrain boundary. Development. 2020 Jun 8;147(11):dev186882. doi: 10.1242/dev.186882. PMID: 32439756.

Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization

Authors:
Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C
Citation:
Nucleic Acids Res. 2019 Nov 28. pii: gkz1117. doi: 10.1093/nar/gkz1117. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The Spinal Muscular Atrophy (SMA) gene SMN was recently duplicated (SMN1 and SMN2) in higher primates. Furthermore, invasion of...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz1117/5645010
Delivery Method:
cell scraping
Organism or Cell Type:
cell culture: human SMA type-I fibroblasts GM03813
Citation Extract:
Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C. Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization. Nucleic Acids Res. 2019 Nov 28. pii: gkz1117. doi: 10.1093/nar/gkz1117. [Epub ahead of print].

The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors

Authors:
Jurynec MJ, Bai X, Bisgrove BW, Jackson H, Nechiporuk A, Palu RAS, Grunwald HA, Su YC, Hoshijima K, Yost HJ, Zon LI, Grunwald DJ
Citation:
Development. 2019 Nov 29. pii: dev.180133. doi: 10.1242/dev.180133. [Epub ahead of print]
Epub:
Yes
Abstract:
Multipotent progenitor populations are necessary for generating diverse tissue types during embryogenesis. We show the...
Link:
https://dev.biologists.org/content/early/2019/11/25/dev.180133
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jurynec MJ, Bai X, Bisgrove BW, Jackson H, Nechiporuk A, Palu RAS, Grunwald HA, Su YC, Hoshijima K, Yost HJ, Zon LI, Grunwald DJ. The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development. 2019 Nov 29. pii: dev.180133. doi: 10.1242/dev.180133. [Epub ahead of print].

Exon-Mediated Activation of Transcription Starts

Authors:
Fiszbein A, Krick KS, Begg BE, Burge CB
Citation:
Cell. 2019 Dec 12;179(7):1551-1565.e17. doi: 10.1016/j.cell.2019.11.002. Epub 2019 Nov 28. PMID: 31787377; PMCID: PMC7351029
Epub:
Yes
Abstract:
The processing of RNA transcripts from mammalian genes occurs in proximity to their transcription. Here, we describe a...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7351029/
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: mouse fibroblasts
Citation Extract:
Fiszbein A, Krick KS, Begg BE, Burge CB. Exon-Mediated Activation of Transcription Starts. Cell. 2019 Dec 12;179(7):1551-1565.e17. doi: 10.1016/j.cell.2019.11.002. Epub 2019 Nov 28. PMID: 31787377; PMCID: PMC7351029.

Whole-Exome Sequencing Identifies Damaging de novo Variants in Anencephalic Cases

Authors:
Wang L, Ren A, Tian T, Li N, Cao X, Zhang P, Jin L, Li Z, Shen Y, Zhang B, Finnell RH, Lei Y
Citation:
Front Neurosci. 2019;13:1285. doi:10.3389/fnins.2019.01285
Epub:
Not Epub
Abstract:
Background: Anencephaly is a lethal neural tube defect (NTD). Although variants in several genes have been implicated in the...
Link:
https://www.frontiersin.org/articles/10.3389/fnins.2019.01285/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang L, Ren A, Tian T, Li N, Cao X, Zhang P, Jin L, Li Z, Shen Y, Zhang B, Finnell RH, Lei Y. Whole-Exome Sequencing Identifies Damaging de novo Variants in Anencephalic Cases. Front Neurosci. 2019;13:1285. doi:10.3389/fnins.2019.01285.

Effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish

Authors:
Cheng B, Zhang H, Jia K, Li E, Zhang S, Yu H, Cao Z, Xiong G, Hu C, Lu H
Citation:
Fish Shellfish Immunol. 2019 Nov 28. pii: S1050-4648(19)31109-X. doi: 10.1016/j.fsi.2019.11.066. [Epub ahead of print]
Epub:
Yes
Abstract:
Our study investigated the effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish. 10 h post-...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S105046481931109X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng B, Zhang H, Jia K, Li E, Zhang S, Yu H, Cao Z, Xiong G, Hu C, Lu H. Effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish. Fish Shellfish Immunol. 2019 Nov 28. pii: S1050-4648(19)31109-X. doi: 10.1016/j.fsi.2019.11.066. [Epub ahead of print].

Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels

Authors:
Willson JA, Bork BS, Muir CA, Damjanovski S
Citation:
J Biol Res (Thessaloniki). 2019;26:16. doi:10.1186/s40709-019-0108-8
Epub:
Not Epub
Abstract:
Background: MT1-MMP is a cell-surface enzyme whose regulation of pro-MMP-2 and ERK activation position it as a key facilitator...
Link:
https://link.springer.com/article/10.1186%2Fs40709-019-0108-8
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: Xenopus A6 cells
Citation Extract:
Willson JA, Bork BS, Muir CA, Damjanovski S. Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels. J Biol Res (Thessaloniki). 2019;26:16. doi:10.1186/s40709-019-0108-8.

Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools

Authors:
Johansson M, Giger FA, Fielding T, Houart C
Citation:
Dev Cell. 2019 Nov 26. pii: S1534-5807(19)30904-9. doi: 10.1016/j.devcel.2019.10.026. [Epub ahead of print]
Epub:
Yes
Abstract:
Dickkopf-1 (Dkk1) is a secreted Wnt antagonist with a well-established role in head induction during development. Numerous...
Link:
https://www.sciencedirect.com/science/article/pii/S1534580719309049
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Johansson M, Giger FA, Fielding T, Houart C. Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools. Dev Cell. 2019 Nov 26. pii: S1534-5807(19)30904-9. doi: 10.1016/j.devcel.2019.10.026. [Epub ahead of print].

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