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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit

Authors:
Jokura K, Ueda N, Gühmann M, Yañez-Guerra LA, Słowiński P, Wedgwood KCA, Jékely G
Citation:
eLife. 2023;12:RP91258. doi:10.7554/eLife.91258.1
Epub:
Not Epub
Abstract:
Nitric oxide (NO) produced by nitric-oxide synthase (NOS) is a key regulator of animal physiology. Here we uncover a function...
Link:
https://elifesciences.org/reviewed-preprints/91258
Delivery Method:
microinjection
Organism or Cell Type:
Platynereis dumerilii (annelid)
Citation Extract:
Jokura K, Ueda N, Gühmann M, Yañez-Guerra LA, Słowiński P, Wedgwood KCA, Jékely G. Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit. eLife. 2023;12:RP91258. doi:10.7554/eLife.91258.1.

Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression

Authors:
González-Martínez I, Cerro-Herreros E, Moreno N, García-Rey A, Espinosa-Espinosa J, Carrascosa-Sàez M, Piqueras-Losilla D, Arzumanov A, Seoane-Miraz D, Jad Y, Raz R, Wood MJ, Varela MA, Llamusí B, Artero R
Citation:
Mol Ther Nucleic Acids. 2023 Sep 5;34:102024. doi: 10.1016/j.omtn.2023.09.001. eCollection 2023 Dec 12
Epub:
Not Epub
Abstract:
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by a CTG repeat expansion in the DMPK gene that...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00237-8
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: DM1, mice
Citation Extract:
González-Martínez I, Cerro-Herreros E, Moreno N, García-Rey A, Espinosa-Espinosa J, Carrascosa-Sàez M, Piqueras-Losilla D, Arzumanov A, Seoane-Miraz D, Jad Y, Raz R, Wood MJ, Varela MA, Llamusí B, Artero R. Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. Mol Ther Nucleic Acids. 2023 Sep 5;34:102024. doi: 10.1016/j.omtn.2023.09.001. eCollection 2023 Dec 12.

SASH1 contributes to glial cell migration in the early development of the central nervous system

Authors:
Zhou Z, Wang P, Wang Q, Dong Z, Chen X, Zhuo R, Wu R, Liu Y, Yang L, Liu M
Citation:
Dev Biol. 2023 Sep 21:S0012-1606(23)00160-4. doi: 10.1016/j.ydbio.2023.09.006. Online ahead of print
Epub:
Yes
Abstract:
SAM and SH3 domain-containing 1 (SASH1), a member of the Sly protein family, is a tumor suppressor gene that has been studied...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160623001604
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou Z, Wang P, Wang Q, Dong Z, Chen X, Zhuo R, Wu R, Liu Y, Yang L, Liu M. SASH1 contributes to glial cell migration in the early development of the central nervous system. Dev Biol. 2023 Sep 21:S0012-1606(23)00160-4. doi: 10.1016/j.ydbio.2023.09.006. Online ahead of print.

Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry

Authors:
Kurup AJ, Bailet F, Fürthauer M
Citation:
Nat Commun. 2024 Aug 2;15(1):6547. doi: 10.1038/s41467-024-50868-y. PMID: 39095343; PMCID: PMC11297164.
Epub:
Not Epub
Abstract:
Myosin1D (Myo1D) has recently emerged as a conserved regulator of animal Left-Right (LR) asymmetry that governs the...
Link:
https://www.nature.com/articles/s41467-024-50868-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kurup AJ, Bailet F, Fürthauer M. Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nat Commun. 2024 Aug 2;15(1):6547. doi: 10.1038/s41467-024-50868-y. PMID: 39095343; PMCID: PMC11297164..

Discovery of seven hox genes in zebrafish thrombopoiesis

Authors:
Sundaramoorthi H, Fallatah W, Mary J, Jagadeeswaran P
Citation:
Blood Cells Mol Dis. 2023 Aug 30;104:102796. doi: 10.1016/j.bcmd.2023.102796. Online ahead of print
Epub:
Not Epub
Abstract:
Thrombopoiesis is the production of platelets from megakaryocytes in the bone marrow of mammals. In fish, thrombopoiesis...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1079979623000736
Delivery Method:
Vivo-Morpholino piggyback
Organism or Cell Type:
zebrafish
Citation Extract:
Sundaramoorthi H, Fallatah W, Mary J, Jagadeeswaran P. Discovery of seven hox genes in zebrafish thrombopoiesis. Blood Cells Mol Dis. 2023 Aug 30;104:102796. doi: 10.1016/j.bcmd.2023.102796. Online ahead of print.

Transposable elements drive the evolution of metazoan zinc finger genes

Authors:
Wells JN, Chang NC, McCormick J, Coleman C, Ramos N, Jin B, Feschotte C
Citation:
Genome Res. 2023 Sep 15. doi: 10.1101/gr.277966.123. Online ahead of print
Epub:
Yes
Abstract:
Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in metazoans. ZNF evolution is highly...
Link:
https://genome.cshlp.org/content/early/2023/09/15/gr.277966.123
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wells JN, Chang NC, McCormick J, Coleman C, Ramos N, Jin B, Feschotte C. Transposable elements drive the evolution of metazoan zinc finger genes. Genome Res. 2023 Sep 15. doi: 10.1101/gr.277966.123. Online ahead of print.

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation

Authors:
Gupta D, Orehek S, Turunen J, O’Donovan L, Gait MJ, El-Andaloussi S, Wood MJA
Citation:
Cells. 2023;12:2285. doi:10.3390/ cells12182285
Epub:
Not Epub
Abstract:
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in maintaining normal homeostatic processes under the...
Link:
https://www.mdpi.com/2073-4409/12/18/2285
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Gupta D, Orehek S, Turunen J, O’Donovan L, Gait MJ, El-Andaloussi S, Wood MJA. Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation. Cells. 2023;12:2285. doi:10.3390/ cells12182285.

Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain

Authors:
Thomas R, Connolly KJ, Brekk OR, Hinrich AJ, Hastings ML, Isacson O, Hallett PJ
Citation:
Sci Rep. 2023;13, 15164. doi:10.1038/s41598-023-41240-z
Epub:
Not Epub
Abstract:
Inflammatory processes and mechanisms are of central importance in neurodegenerative diseases. In the brain, α-...
Link:
https://www.nature.com/articles/s41598-023-41240-z
Delivery Method:
intracerebroventricular (i.c.v.) infusion, stereotaxic brain injection
Organism or Cell Type:
mice
Citation Extract:
Thomas R, Connolly KJ, Brekk OR, Hinrich AJ, Hastings ML, Isacson O, Hallett PJ. Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain. Sci Rep. 2023;13, 15164. doi:10.1038/s41598-023-41240-z.

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

Authors:
Sahai-Hernandez P, Pouget C, Eyal S, Svoboda O, Chacon J, Grimm L, Gjøen T, Traver D
Citation:
Elife. 2023 Sep 11;12:e58300. doi: 10.7554/eLife.58300
Epub:
Not Epub
Abstract:
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic stem...
Link:
https://elifesciences.org/articles/58300
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sahai-Hernandez P, Pouget C, Eyal S, Svoboda O, Chacon J, Grimm L, Gjøen T, Traver D. Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. Elife. 2023 Sep 11;12:e58300. doi: 10.7554/eLife.58300.

β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus

Authors:
Gao J, Lu Y, Luo Y, Duan X, Chen P, Zhang X, Wu X, Qiu M, Shen W
Citation:
Int J Mol Sci. 2023 Sep 2;24(17):13593. doi: 10.3390/ijms241713593
Epub:
Not Epub
Abstract:
In the vertebrate brain, sensory experience plays a crucial role in shaping thalamocortical connections for visual processing....
Link:
https://www.mdpi.com/1422-0067/24/17/13593
Delivery Method:
electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gao J, Lu Y, Luo Y, Duan X, Chen P, Zhang X, Wu X, Qiu M, Shen W. β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus. Int J Mol Sci. 2023 Sep 2;24(17):13593. doi: 10.3390/ijms241713593.

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