You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina

Authors:
Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR
Citation:
PLoS Genet. 2023 Nov 6;19(11):e1011010. doi: 10.1371/journal.pgen.1011010. Online ahead of print
Epub:
Not Epub
Abstract:
Damage to light-sensing photoreceptors (PRs) occurs in highly prevalent retinal diseases. As humans cannot regenerate new PRs,...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011010
Delivery Method:
injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR. Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. PLoS Genet. 2023 Nov 6;19(11):e1011010. doi: 10.1371/journal.pgen.1011010. Online ahead of print.

The zebrafish paralog six2b is required for early proximal pronephros morphogenesis

Authors:
Belcher B, Vestal J, Lane S, Kell M, Smith L, Camarata T
Citation:
Sci Rep. 2023 Nov 11;13(1):19699. doi: 10.1038/s41598-023-47046-3
Epub:
Not Epub
Abstract:
The transcription factor Six2 plays a crucial role in maintaining self-renewing nephron progenitor cap mesenchyme (CM) during...
Link:
https://www.nature.com/articles/s41598-023-47046-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Belcher B, Vestal J, Lane S, Kell M, Smith L, Camarata T. The zebrafish paralog six2b is required for early proximal pronephros morphogenesis. Sci Rep. 2023 Nov 11;13(1):19699. doi: 10.1038/s41598-023-47046-3.

Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia

Authors:
Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN
Citation:
Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777. Epub 2023 Nov 3
Epub:
Not Epub
Abstract:
Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and...
Link:
https://www.science.org/doi/10.1126/sciadv.adi4777
Delivery Method:
nanoparticle intraperitoneal (i.p.)
Organism or Cell Type:
mice
Citation Extract:
Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN. Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777. Epub 2023 Nov 3.

Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix

Authors:
Gupta M, Kurth T, Heinemann F, Schwille P, Keil S, Knopf F, Brand M
Citation:
Biophys J. 2025 Mar 18;124(6):996-1010. doi: 10.1016/j.bpj.2024.12.009. Epub 2024 Dec 11. PMID: 39668564; PMCID: PMC11947464
Epub:
Not Epub
Abstract:
Embryonic development is orchestrated by the action of morphogens, which spread out from a local source and activate, in a...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11947464/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gupta M, Kurth T, Heinemann F, Schwille P, Keil S, Knopf F, Brand M. Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix. Biophys J. 2025 Mar 18;124(6):996-1010. doi: 10.1016/j.bpj.2024.12.009. Epub 2024 Dec 11. PMID: 39668564; PMCID: PMC11947464.

Analysis of Vascular Morphogenesis in Zebrafish

Authors:
Hubert M, Herzog W
Citation:
Methods Mol Biol. 2023;2608:425-450. doi: 10.1007/978-1-0716-2887-4_24
Epub:
Not Epub
Abstract:
Analysis of cardiovascular development in zebrafish embryos has become a major driver of vascular research in recent years....
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2887-4_24
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hubert M, Herzog W. Analysis of Vascular Morphogenesis in Zebrafish. Methods Mol Biol. 2023;2608:425-450. doi: 10.1007/978-1-0716-2887-4_24.

Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates

Authors:
Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR
Citation:
ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634
Epub:
Yes
Abstract:
Fuchs’ corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective...
Link:
https://pubs.acs.org/doi/10.1021/acsomega.3c05634
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: FECD patient-derived F35T corneal endothelial cells
Citation Extract:
Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR. Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates. ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634.

nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling

Authors:
Yang S, Xu X, Yin Z, Liu Y, Wang H, Guo J, Wang F, Bao Y, Zhang T, Sun S
Citation:
Heliyon. 2023;[Epub] doi:10.1016/j.heliyon.2023.e21915
Epub:
Not Epub
Abstract:
Nkx2.3, a transcription factor, plays important roles in various developmental processes. However, the mechanisms underlying...
Link:
https://www.cell.com/heliyon/fulltext/S2405-8440(23)09123-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang S, Xu X, Yin Z, Liu Y, Wang H, Guo J, Wang F, Bao Y, Zhang T, Sun S. nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling. Heliyon. 2023;[Epub] doi:10.1016/j.heliyon.2023.e21915.

Interaction of Gαi2 with EB1 controls microtubule dynamics and Rac1 activity in Xenopus neural crest cell migration

Authors:
Villaseca S, Leal JI, Tovar LM, Ruiz MJ, Guajardo J, Morales-Navarrete H, Mayor R, Torrejón M
Citation:
Development. 2025 Apr 15;152(8):dev204235. doi: 10.1242/dev.204235. Epub 2025 Apr 22. PMID: 40136014
Epub:
Not Epub
Abstract:
Cell migration is crucial in embryonic development, tissue repair and cancer metastasis, driven by the actin and tubulin...
Link:
https://journals.biologists.com/dev/article-abstract/152/8/dev204235/367740/Interaction-of-G-i2-with-EB1-controls-microtubule
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Villaseca S, Leal JI, Tovar LM, Ruiz MJ, Guajardo J, Morales-Navarrete H, Mayor R, Torrejón M. Interaction of Gαi2 with EB1 controls microtubule dynamics and Rac1 activity in Xenopus neural crest cell migration. Development. 2025 Apr 15;152(8):dev204235. doi: 10.1242/dev.204235. Epub 2025 Apr 22. PMID: 40136014.

Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz

Authors:
Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, Ikawa T, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M, Takeuchi O
Citation:
Blood. 2023 Nov 3:blood.2023020903. doi: 10.1182/blood.2023020903. Online ahead of print
Epub:
Yes
Abstract:
Regulation of lineage biases in hematopoietic stem and progenitor cells (HSPCs) is pivotal for balanced hematopoietic output....
Link:
https://ashpublications.org/blood/article/doi/10.1182/blood.2023020903/498619/Regulation-of-lymphoid-myeloid-lineage-bias
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: hematopoetic stem cells
Citation Extract:
Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, Ikawa T, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M, Takeuchi O. Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz. Blood. 2023 Nov 3:blood.2023020903. doi: 10.1182/blood.2023020903. Online ahead of print.

Characterization of Na+ currents regulating intrinsic excitability of optic tectal neurons

Authors:
Thompson AC, Aizenman CD
Citation:
Life Sci Alliance. 2023 Nov 2;7(1):e202302232. doi: 10.26508/lsa.202302232. Print 2024 Jan
Epub:
Not Epub
Abstract:
Developing neurons adapt their intrinsic excitability to maintain stable output despite changing synaptic input. The mechanisms...
Link:
https://www.life-science-alliance.org/content/7/1/e202302232
Delivery Method:
injection then electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Thompson AC, Aizenman CD. Characterization of Na+ currents regulating intrinsic excitability of optic tectal neurons. Life Sci Alliance. 2023 Nov 2;7(1):e202302232. doi: 10.26508/lsa.202302232. Print 2024 Jan.

Pages