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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
Pannexin 1 drives efficient epithelial repair after tissue injury
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Citation:
Sci Immunol. 2022 May 13;7(71):eabm4032. doi: 10.1126/sciimmunol.abm4032. Epub 2022 May 13 Epub:
Not Epub Abstract:
Epithelial tissues such as lung and skin are exposed to the environment and therefore particularly vulnerable to damage during... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lucas CD, Medina CB, Bruton FA, Dorward DA, Raymond MH, Tufan T, Etchegaray JI, Barron B, Oremek MEM, Arandjelovic S, Farber E, Onngut-Gumuscu S, Ke E, Whyte MKB, Rossi AG, Ravichandran KS. Pannexin 1 drives efficient epithelial repair after tissue injury. Sci Immunol. 2022 May 13;7(71):eabm4032. doi: 10.1126/sciimmunol.abm4032. Epub 2022 May 13. |
Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury
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Citation:
Int J Mol Sci. 2022;23(17):9582. doi:10.3390/ijms23179582 Epub:
Not Epub Abstract:
Acute kidney injury (AKI) is commonly associated with severe human diseases, and often worsens the outcome in hospitalized... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhuang M, Scholz A, Walz G, Yakulov TA. Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury. Int J Mol Sci. 2022;23(17):9582. doi:10.3390/ijms23179582. |
PPMO-mediated exon skipping induces uniform sarcolemmal dystrophin rescue with dose-dependent restoration of circulating microRNA biomarkers and muscle biophysical properties
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Citation:
Molec Ther Nucleic Acids. 2022;[Epub ahead of print] doi:10.1016/j.omtn.2022.08.033 Epub:
Not Epub Abstract:
Therapies that restore dystrophin expression are presumed to correct Duchenne muscular dystrophy (DMD), with antisense-mediated... Delivery Method:
injection Organism or Cell Type:
mice Citation Extract: Chwalenia K, Oieni J, Zemła J, Lekka M, Ahlskog N, Coenen-Stass AML, McClorey G, Wood MJA, Lomonosova Y, Roberts TC. PPMO-mediated exon skipping induces uniform sarcolemmal dystrophin rescue with dose-dependent restoration of circulating microRNA biomarkers and muscle biophysical properties. Molec Ther Nucleic Acids. 2022;[Epub ahead of print] doi:10.1016/j.omtn.2022.08.033. |
Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops
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Citation:
Front Cell Dev Biol. 2022;10:982477 doi: 10.3389/fcell.2022.982477 Epub:
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The T-box family transcription factor Eomesodermin (Eomes) is present in all vertebrates, with many key roles in the developing... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Talbot CD, Walsh MD, Cutty SJ, Elsayed R, Vlachaki E, Bruce AEE, Wardle FC, Nelson AC. Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops. Front Cell Dev Biol. 2022;10:982477 doi: 10.3389/fcell.2022.982477. |
TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration
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Citation:
CNS Neurosci Ther. 2022 Aug 19. doi:10.1111/cns.13943. Online ahead of print Epub:
Yes Abstract:
Aims: TFG-related axonal Charcot-Marie-Tooth (CMT) disease is a late-onset, autosomal dominant, hereditary motor, and sensory... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen X, Liu F, Chen K, Wang Y, Yin A, Kang X, Yang S, Zhao H, Dong S, Li Y, Chen J, Wu Y. TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS Neurosci Ther. 2022 Aug 19. doi:10.1111/cns.13943. Online ahead of print. |
A Cell-Penetrating Peptide Enhances Delivery and Efficacy of Phosphorodiamidate Morpholino Oligomers in mdx Mice
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Citation:
Mol Ther Nucleic Acids. 2022;[Epub ahead of print] doi:10.1016/j.omtn.2022.08.019 Epub:
Yes Abstract:
Antisense RNA technology is a strategy for the treatment of Duchenne muscular dystrophy (DMD), a progressive and universally... Citation Extract: Gan L, Wu LCL, Wood JA, Yao M, Treleaven CM, Estrella NL, Wentworth BM, Hanson GL, Passini MA. A Cell-Penetrating Peptide Enhances Delivery and Efficacy of Phosphorodiamidate Morpholino Oligomers in mdx Mice. Mol Ther Nucleic Acids. 2022;[Epub ahead of print] doi:10.1016/j.omtn.2022.08.019. |
Simultaneous crosslinking of CD20 and CD38 receptors by drug-free macromolecular therapeutics enhances B cell apoptosis in vitro and in vivo
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Citation:
J Control Release. 2022 Aug 26:S0168-3659(22)00552-1. doi: 10.1016/j.jconrel.2022.08.045. Online ahead of print Epub:
Yes Abstract:
Drug-Free Macromolecular Therapeutics (DFMT) is a new paradigm in macromolecular therapeutics that induces apoptosis in target... Organism or Cell Type:
cell culture: Raji (CD20+; CD38+) B cells; xenograft mouse Citation Extract: Tommy Gambles M, Li J, Christopher Radford D, Sborov D, Shami P, Yang J, Kopeček J. Simultaneous crosslinking of CD20 and CD38 receptors by drug-free macromolecular therapeutics enhances B cell apoptosis in vitro and in vivo. J Control Release. 2022 Aug 26:S0168-3659(22)00552-1. doi: 10.1016/j.jconrel.2022.08.045. Online ahead of print. |
Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing
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Citation:
Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2207956119. doi: 10.1073/pnas.2207956119. Epub 2022 Aug 29 Epub:
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Recent advances in drug development have seen numerous successful clinical translations using synthetic antisense... Delivery Method:
lipofectin Organism or Cell Type:
cell culture: murine myotubes Citation Extract: Le BT, Paul S, Jastrzebska K, Langer H, Caruthers MH, Veedu RN. Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2207956119. doi: 10.1073/pnas.2207956119. Epub 2022 Aug 29. |
Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development
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Citation:
J Vis Exp. 2022 Aug 9;(186). doi: 10.3791/63324 Epub:
Not Epub Abstract:
The morpholino oligomer-based knockdown system has been used to identify the function of various gene products through loss or... Link:
Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zakaria ZZ, Eisa-Beygi S, Benslimane FM, Ramchandran R, Yalcin HC. Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development. J Vis Exp. 2022 Aug 9;(186). doi: 10.3791/63324. |
Antisense Morpholino-Based In Vitro Correction of a Pseudoexon-Generating Variant in the SGCB Gene
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Citation:
Int J Mol Sci. 2022;23(17):9817. doi:10.3390/ijms23179817 Epub:
Not Epub Abstract:
Limb-girdle muscular dystrophies (LGMD) are clinically and genetically heterogenous presentations displaying predominantly... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
human induced pluripotent stem cells (iPSC) Citation Extract: Magri F, Zanotti S, Salani S, Fortunato F, Ciscato P, Gerevini S, Maggi L, Sciacco M, Moggio M, Corti S, Bresolin N, Comi GP, Ronchi D. Antisense Morpholino-Based In Vitro Correction of a Pseudoexon-Generating Variant in the SGCB Gene. Int J Mol Sci. 2022;23(17):9817. doi:10.3390/ijms23179817. |