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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

Authors:
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald J, Shen K, Ma DK
Citation:
Nat Comm. 2022;13:6805. doi:10.1038/s41467-022-34450-y
Epub:
Not Epub
Abstract:
Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through conserved homeostatic...
Link:
https://www.nature.com/articles/s41467-022-34450-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald J, Shen K, Ma DK. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Nat Comm. 2022;13:6805. doi:10.1038/s41467-022-34450-y.

Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension

Authors:
Weng S, Hayashi M, Inoue Y, Wallingford JB
Citation:
Curr Biol. 2025 Jan 6;35(1):1-10.e3. doi: 10.1016/j.cub.2024.10.070. Epub 2024 Nov 27. PMID: 39610250; PMCID: PMC11706704
Epub:
Not Epub
Abstract:
Convergent extension (CE) is an evolutionarily conserved developmental process that elongates tissues and organs via collective...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11706704/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Weng S, Hayashi M, Inoue Y, Wallingford JB. Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension. Curr Biol. 2025 Jan 6;35(1):1-10.e3. doi: 10.1016/j.cub.2024.10.070. Epub 2024 Nov 27. PMID: 39610250; PMCID: PMC11706704.

Syntaxin 4 is essential for hearing in human and zebrafish

Authors:
Schrauwen I, Ghaffar A, Bharadwaj T, Shah K, Rehman S, Acharya A, Liaqat K, Lin NS, Everard JL, Khan A, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM
Citation:
Hum Mol Genet. 2022 Nov 10:ddac257. doi: 10.1093/hmg/ddac257. Online ahead of print
Epub:
Not Epub
Abstract:
Congenital hearing impairment is a genetically highly heterogenous disorder in which prompt recognition and intervention are...
Link:
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddac257/6820909
Organism or Cell Type:
zebrafish
Citation Extract:
Schrauwen I, Ghaffar A, Bharadwaj T, Shah K, Rehman S, Acharya A, Liaqat K, Lin NS, Everard JL, Khan A, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM. Syntaxin 4 is essential for hearing in human and zebrafish. Hum Mol Genet. 2022 Nov 10:ddac257. doi: 10.1093/hmg/ddac257. Online ahead of print.

The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network

Authors:
Chatzifrangkeskou M, Skourides PA
Citation:
Sci Rep. 2022 Nov 8;12(1):19028. doi: 10.1038/s41598-022-22871-0
Epub:
Not Epub
Abstract:
The Ciliary Adhesion (CA) complex forms in close association with the basal bodies of cilia during the early stages of...
Link:
https://www.nature.com/articles/s41598-022-22871-0
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chatzifrangkeskou M, Skourides PA. The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network. Sci Rep. 2022 Nov 8;12(1):19028. doi: 10.1038/s41598-022-22871-0.

Acupuncture Needle-Based Transistor Neuroprobe for In Vivo Monitoring of Neurotransmitter

Authors:
Zhou Y, Liu B, Lei Y, Tang L, Li T, Yu S, Zhang GJ, Li YT
Citation:
Small. 2022 Dec;18(52):e2204142. doi: 10.1002/smll.202204142. Epub 2022 Nov 7. PMID: 36344461
Epub:
Not Epub
Abstract:
Chemical communication via neurotransmitters is central to brain functions. Nevertheless, in vivo real-time monitoring of...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/smll.202204142
Organism or Cell Type:
rat
Citation Extract:
Zhou Y, Liu B, Lei Y, Tang L, Li T, Yu S, Zhang GJ, Li YT. Acupuncture Needle-Based Transistor Neuroprobe for In Vivo Monitoring of Neurotransmitter. Small. 2022 Dec;18(52):e2204142. doi: 10.1002/smll.202204142. Epub 2022 Nov 7. PMID: 36344461.

osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2

Authors:
Drummond BE, Chambers BE, Wesselman HM, Gibson S, Arceri L, Ulrich MN, Gerlach GF, Kroeger PT, Leshchiner I, Goessling W, Wingert RA
Citation:
Biomedicines. 2022;10(11):2868. doi:10.3390/biomedicines10112868
Epub:
Not Epub
Abstract:
Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of...
Link:
https://www.mdpi.com/2227-9059/10/11/2868
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Drummond BE, Chambers BE, Wesselman HM, Gibson S, Arceri L, Ulrich MN, Gerlach GF, Kroeger PT, Leshchiner I, Goessling W, Wingert RA. osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 2022;10(11):2868. doi:10.3390/biomedicines10112868.

Antibody-oligonucleotide conjugate achieves central nervous system delivery in animal models for spinal muscular atrophy

Authors:
Hammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI
Citation:
JCI Insight. 2022 Nov 8:e154142. doi: 10.1172/jci.insight.154142. Online ahead of print
Epub:
Yes
Abstract:
Antisense oligonucleotides (ASOs) have emerged as one of the most innovative new genetic drug modalities. However, their high...
Link:
https://insight.jci.org/articles/view/154142
Delivery Method:
antibody-linked
Organism or Cell Type:
mice
Citation Extract:
Hammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI. Antibody-oligonucleotide conjugate achieves central nervous system delivery in animal models for spinal muscular atrophy. JCI Insight. 2022 Nov 8:e154142. doi: 10.1172/jci.insight.154142. Online ahead of print.

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR

Authors:
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, Owens NDL, Khokha MK
Citation:
Nat Commun. 2022 Nov 5;13(1):6681. doi: 10.1038/s41467-022-34363-w
Epub:
Not Epub
Abstract:
Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic development and adult tissue...
Link:
https://www.nature.com/articles/s41467-022-34363-w
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, Owens NDL, Khokha MK. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nat Commun. 2022 Nov 5;13(1):6681. doi: 10.1038/s41467-022-34363-w.

Convergence of coronary artery disease genes onto endothelial cell programs

Authors:
Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM
Citation:
Nature. 2024 Feb;626(8000):799-807. doi: 10.1038/s41586-024-07022-x. Epub 2024 Feb 7. PMID: 38326615; PMCID: PMC10921916
Epub:
Not Epub
Abstract:
Linking variants from genome-wide association studies (GWAS) to underlying mechanisms of disease remains a challenge1-3. For...
Link:
https://www.nature.com/articles/s41586-024-07022-x
Organism or Cell Type:
zebrafish
Citation Extract:
Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM. Convergence of coronary artery disease genes onto endothelial cell programs. Nature. 2024 Feb;626(8000):799-807. doi: 10.1038/s41586-024-07022-x. Epub 2024 Feb 7. PMID: 38326615; PMCID: PMC10921916.

Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis

Authors:
Rosa JB, Nassman KY, Sagasti A
Citation:
Mol Biol Cell. 2022;[Epub ahead of print] doi:10.1091/mbc.E22-09-0396
Epub:
Not Epub
Abstract:
Epithelial cell properties are determined by the polarized distribution of membrane lipids, the cytoskeleton, and adhesive...
Link:
https://www.molbiolcell.org/doi/10.1091/mbc.E22-09-0396
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rosa JB, Nassman KY, Sagasti A. Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis. Mol Biol Cell. 2022;[Epub ahead of print] doi:10.1091/mbc.E22-09-0396.

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