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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish

Authors:
Arora P, Dongre S, Raman R, Sonawane M
Citation:
eLife. 2020;9:e49064. doi:10.7554/eLife.49064
Epub:
Not Epub
Abstract:
The epidermis, a multilayered epithelium, surrounds and protects the vertebrate body. It develops from a bilayered epithelium...
Link:
https://elifesciences.org/articles/49064
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Arora P, Dongre S, Raman R, Sonawane M. Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish. eLife. 2020;9:e49064. doi:10.7554/eLife.49064.

The gap junction protein Connexin 43 controls multiple aspects of cranial neural crest cell development

Authors:
Jourdeuil K, Taneyhill LA
Citation:
J Cell Sci. 2020;[Epub ahead of print] doi:10.1242/jcs.235440
Epub:
Not Epub
Abstract:
Gap junctions are intercellular channels between cells that facilitate cell-cell communication. Connexin 43 (Cx43), the...
Link:
https://jcs.biologists.org/content/early/2020/01/20/jcs.235440
Organism or Cell Type:
Gallus gallus (chick) cultures and in vivo
Citation Extract:
Jourdeuil K, Taneyhill LA. The gap junction protein Connexin 43 controls multiple aspects of cranial neural crest cell development. J Cell Sci. 2020;[Epub ahead of print] doi:10.1242/jcs.235440.

Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones

Authors:
Kundu T, Dutta P, Nagar D, Maiti S, Ghose A
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.18.911131
Epub:
Not Epub
Abstract:
Dynamic co-regulation of the actin and microtubule subsystems enables the highly precise and adaptive remodeling of the...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.18.911131v1
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: primary Gallus gallus (chick) neurons
Citation Extract:
Kundu T, Dutta P, Nagar D, Maiti S, Ghose A. Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.18.911131.

Kctd15 regulates nephron segment development by repressing Tfap2a activity

Authors:
Chambers BE, Clark EG, Gatz AE, Wingert RA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.17.910760
Epub:
Not Epub
Abstract:
A functional vertebrate kidney relies on structural units called nephrons, which are epithelial tubules that contain a sequence...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.17.910760v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chambers BE, Clark EG, Gatz AE, Wingert RA. Kctd15 regulates nephron segment development by repressing Tfap2a activity. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.17.910760 .

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Authors:
Kainov YA, Makeyev EV
Citation:
Nat Commun. 2020 Jan 17;11(1):361. doi: 10.1038/s41467-019-14204-z
Epub:
Not Epub
Abstract:
Eukaryotic gene expression relies on extensive crosstalk between transcription and RNA processing. Changes in this composite...
Link:
https://www.nature.com/articles/s41467-019-14204-z
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: A2lox mouse ESCs (embryonic stem cells)
Citation Extract:
Kainov YA, Makeyev EV. A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells. Nat Commun. 2020 Jan 17;11(1):361. doi: 10.1038/s41467-019-14204-z.

ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin

Authors:
Tanaka I, Chakraborty A, Saulnier O, Benoit-Pilven C, Vacher S, Labiod D, Lam EWF, Bièche I, Delattre O, Pouzoulet F, Auboeuf D, Vagner S, Dutertre M
Citation:
Nucleic Acids Res. 2020 Jan 16. pii: gkz1213. doi: 10.1093/nar/gkz1213. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Besides analyses of specific alternative splicing (AS) variants, little is known about AS regulatory pathways and programs...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz1213/5707190
Delivery Method:
Endo-Porter PEG; Vivo-Morpholino
Organism or Cell Type:
cell culture: MCF7-DoxoR; female Swiss Nu/nu mice intratumoral
Citation Extract:
Tanaka I, Chakraborty A, Saulnier O, Benoit-Pilven C, Vacher S, Labiod D, Lam EWF, Bièche I, Delattre O, Pouzoulet F, Auboeuf D, Vagner S, Dutertre M. ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin. Nucleic Acids Res. 2020 Jan 16. pii: gkz1213. doi: 10.1093/nar/gkz1213. [Epub ahead of print].

Microglial activation increases cocaine self-administration following adolescent nicotine exposure

Authors:
Linker KE, Elabd MG, Tawadrous P, Cano M, Green KN, Wood MA, Leslie FM
Citation:
Nat Commun. 2020 Jan 16;11(1):306. doi: 10.1038/s41467-019-14173-3
Epub:
Not Epub
Abstract:
With the rise of e-cigarette use, teen nicotine exposure is becoming more widespread. Findings from clinical and preclinical...
Link:
https://www.nature.com/articles/s41467-019-14173-3
Delivery Method:
intracranial Vivo-Morpholino
Organism or Cell Type:
Sprague-Dawley rat
Citation Extract:
Linker KE, Elabd MG, Tawadrous P, Cano M, Green KN, Wood MA, Leslie FM. Microglial activation increases cocaine self-administration following adolescent nicotine exposure. Nat Commun. 2020 Jan 16;11(1):306. doi: 10.1038/s41467-019-14173-3.

The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation

Authors:
Wang Y, Liu X, Xie B, Yuan H, Zhang Y, Zhu J
Citation:
Redox Biol. 2020 Jan;28:101313. doi: 10.1016/j.redox.2019.101313. Epub 2019 Sep 2
Epub:
Not Epub
Abstract:
Hypoxia is widely considered as a limiting factor in vertebrate embryonic development, which requires adequate oxygen delivery...
Link:
https://www.sciencedirect.com/science/article/pii/S2213231719305476
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang Y, Liu X, Xie B, Yuan H, Zhang Y, Zhu J. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biol. 2020 Jan;28:101313. doi: 10.1016/j.redox.2019.101313. Epub 2019 Sep 2.

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

Authors:
Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C
Citation:
Elife. 2020 Jan 14;9. pii: e51248. doi: 10.7554/eLife.51248. [Epub ahead of print]
Epub:
Not Epub
Abstract:
A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate axial embryonic patterning. Here we...
Link:
https://elifesciences.org/articles/51248
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. Elife. 2020 Jan 14;9. pii: e51248. doi: 10.7554/eLife.51248. [Epub ahead of print].

Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts

Authors:
Parra M, Zhang W, Vu J, DeWitt M, Conboy JG
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.13.902544
Epub:
Not Epub
Abstract:
Galanin (Gal) is a peptide with a role in neuroendocrine regulation of the liver. In this study we assessed the role of Gal and...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.13.902544v1
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: human erythroblasts
Citation Extract:
Parra M, Zhang W, Vu J, DeWitt M, Conboy JG. Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.13.902544.

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