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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish

Authors:
Zecchin A, Wong B, Tembuyser B, Souffreau J, Van Nuffelen A, Wyns S, Vinckier S, Carmeliet P, Dewerchin M
Citation:
Biochem Biophys Res Commun. 2018 May 3. pii: S0006-291X(18)31037-4. doi: 10.1016/j.bbrc.2018.04.233. [Epub ahead of print]
Epub:
Yes
Abstract:
During embryonic development, lymphatic endothelial cells (LECs) differentiate from venous endothelial cells (VECs), a process...
Link:
https://www.ncbi.nlm.nih.gov/pubmed/29730294
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zecchin A, Wong B, Tembuyser B, Souffreau J, Van Nuffelen A, Wyns S, Vinckier S, Carmeliet P, Dewerchin M. Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish. Biochem Biophys Res Commun. 2018 May 3. pii: S0006-291X(18)31037-4. doi: 10.1016/j.bbrc.2018.04.233. [Epub ahead of print].

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy

Authors:
Burns DT, Donkervoort S, Müller JS, Knierim E, Bharucha-Goebel D, Faqeih EA, Bell SK, AlFaifi AY, Monies D, Millan F, Retterer K, Dyack S, MacKay S, Morales-Gonzalez S, Giunta M, Munro B, Hudson G, Scavina M, Baker L, Massini TC, Lek M, Hu Y, Ezzo D, AlKuraya FS, Kang PB, Griffin H, Foley AR, Schuelke M, Horvath R, Bönnemann CG
Citation:
Am J Hum Genet. 2018 May 3;102(5):858-873. doi: 10.1016/j.ajhg.2018.03.011
Epub:
Not Epub
Abstract:
The exosome is a conserved multi-protein complex that is essential for correct RNA processing. Recessive variants in exosome...
Link:
https://www.cell.com/ajhg/fulltext/S0002-9297(18)30100-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Burns DT, Donkervoort S, Müller JS, Knierim E, Bharucha-Goebel D, Faqeih EA, Bell SK, AlFaifi AY, Monies D, Millan F, Retterer K, Dyack S, MacKay S, Morales-Gonzalez S, Giunta M, Munro B, Hudson G, Scavina M, Baker L, Massini TC, Lek M, Hu Y, Ezzo D, AlKuraya FS, Kang PB, Griffin H, Foley AR, Schuelke M, Horvath R, Bönnemann CG. Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy. Am J Hum Genet. 2018 May 3;102(5):858-873. doi: 10.1016/j.ajhg.2018.03.011.

Temporal and Spatial Post-Transcriptional Regulation of Zebrafish Tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly

Authors:
Chowdhury TA, Koceja C, Eisa-Beygi S, Kleinstiver BP, Kumar SN, Lin CW, Li K, Prabhudesai S, Joung JK, Ramchandran R
Citation:
Arterioscler Thromb Vasc Biol. 2018 May 3. pii: ATVBAHA.118.310848. doi: 10.1161/ATVBAHA.118.310848. [Epub ahead of print]
Epub:
Yes
Abstract:
OBJECTIVE: Tie1 (tyrosine kinase containing immunoglobulin and epidermal growth factor homology 1), an endothelial and...
Link:
http://atvb.ahajournals.org/content/early/2018/05/02/ATVBAHA.118.310848.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chowdhury TA, Koceja C, Eisa-Beygi S, Kleinstiver BP, Kumar SN, Lin CW, Li K, Prabhudesai S, Joung JK, Ramchandran R. Temporal and Spatial Post-Transcriptional Regulation of Zebrafish Tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly. Arterioscler Thromb Vasc Biol. 2018 May 3. pii: ATVBAHA.118.310848. doi: 10.1161/ATVBAHA.118.310848. [Epub ahead of print].

CTCF knockout reveals an essential role for this protein during the zebrafish development

Authors:
Carmona-Aldana F, Zampedri C, Suaste-Olmos F, Murillo-de-Ozores A, Guerrero G, Arzate-Mejía R, Maldonado E, Navarro R, Chimal-Monroy J, Recillas-Targa F
Citation:
Mech Dev. 2018 May 1. pii: S0925-4773(18)30011-X. doi: 10.1016/j.mod.2018.04.006. [Epub ahead of print]
Epub:
Yes
Abstract:
Chromatin regulation and organization are essential processes that regulate gene activity. The CCCTC-binding factor (CTCF) is a...
Link:
https://www.sciencedirect.com/science/article/pii/S092547731830011X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Carmona-Aldana F, Zampedri C, Suaste-Olmos F, Murillo-de-Ozores A, Guerrero G, Arzate-Mejía R, Maldonado E, Navarro R, Chimal-Monroy J, Recillas-Targa F. CTCF knockout reveals an essential role for this protein during the zebrafish development. Mech Dev. 2018 May 1. pii: S0925-4773(18)30011-X. doi: 10.1016/j.mod.2018.04.006. [Epub ahead of print].

Efficient exon skipping of SGCG mutations mediated by phosphorodiamidate morpholino oligomers

Authors:
Wyatt EJ, Demonbreun AR, Kim EY, Puckelwartz MJ, Vo AH, Dellefave-Castillo LM, Gao QQ, Vainzof M, Pavanello RCM, Zatz M, McNally EM
Citation:
JCI Insight. 2018 May 3;3(9). pii: 99357. doi: 10.1172/jci.insight.99357. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Exon skipping uses chemically modified antisense oligonucleotides to modulate RNA splicing. Therapeutically, exon skipping can...
Link:
https://insight.jci.org/articles/view/99357
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human primary fibroblasts differentiated to myogenic cells
Citation Extract:
Wyatt EJ, Demonbreun AR, Kim EY, Puckelwartz MJ, Vo AH, Dellefave-Castillo LM, Gao QQ, Vainzof M, Pavanello RCM, Zatz M, McNally EM. Efficient exon skipping of SGCG mutations mediated by phosphorodiamidate morpholino oligomers. JCI Insight. 2018 May 3;3(9). pii: 99357. doi: 10.1172/jci.insight.99357. [Epub ahead of print].

The Role of Palladin in Podocytes

Authors:
Artelt N, Ludwig TA, Rogge H, Kavvadas P, Siegerist F, Blumenthal A, van den Brandt J, Otey CA, Bang ML, Amann K, Chadjichristos CE, Chatziantoniou C, Endlich K, Endlich N
Citation:
J Am Soc Nephrol. 2018 May 2. pii: ASN.2017091039. doi: 10.1681/ASN.2017091039. [Epub ahead of print]
Epub:
Yes
Abstract:
Background: Podocyte loss and effacement of interdigitating podocyte foot processes are the major cause of a leaky filtration...
Link:
http://jasn.asnjournals.org/content/early/2018/05/01/ASN.2017091039.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Artelt N, Ludwig TA, Rogge H, Kavvadas P, Siegerist F, Blumenthal A, van den Brandt J, Otey CA, Bang ML, Amann K, Chadjichristos CE, Chatziantoniou C, Endlich K, Endlich N. The Role of Palladin in Podocytes. J Am Soc Nephrol. 2018 May 2. pii: ASN.2017091039. doi: 10.1681/ASN.2017091039. [Epub ahead of print].

let-7 MicroRNA-Mediated Regulation of Shh Signaling and the Gene Regulatory Network Is Essential for Retina Regeneration

Authors:
Kaur S, Gupta S, Chaudhary M, Khursheed MA, Mitra S, Kurup AJ, Ramachandran R
Citation:
Cell Rep. 2018;23(5):1409-23. doi:10.1016/j.celrep.2018.04.002
Epub:
Not Epub
Abstract:
Upon injury, Müller glia cells of the zebrafish retina reprogram themselves to progenitor cells with stem cell characteristics...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30531-X
Delivery Method:
injection and electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Kaur S, Gupta S, Chaudhary M, Khursheed MA, Mitra S, Kurup AJ, Ramachandran R. let-7 MicroRNA-Mediated Regulation of Shh Signaling and the Gene Regulatory Network Is Essential for Retina Regeneration. Cell Rep. 2018;23(5):1409-23. doi:10.1016/j.celrep.2018.04.002.

Control of Pem protein level by localized maternal factors for transcriptional regulation in the germline of the ascidian, Halocynthia roretzi

Authors:
Miyaoku K, Nakamoto A, Nishida H, Kumano G
Citation:
PLoS ONE. 2018;13(4):e0196500. doi:10.1371/journal.pone.0196500
Epub:
Not Epub
Abstract:
Localized maternal mRNAs play important roles in embryogenesis, e.g. the establishment of embryonic axes and the developmental...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196500
Delivery Method:
microinjection
Organism or Cell Type:
Halocynthia roretzi
Citation Extract:
Miyaoku K, Nakamoto A, Nishida H, Kumano G. Control of Pem protein level by localized maternal factors for transcriptional regulation in the germline of the ascidian, Halocynthia roretzi. PLoS ONE. 2018;13(4):e0196500. doi:10.1371/journal.pone.0196500.

The left-right asymmetry of liver lobation is generated by Pitx2c-mediated asymmetries in the hepatic diverticulum

Authors:
Womble M, Amin NM, Nascone-Yoder N
Citation:
Dev Biol. 2018;[Epub] doi:10.1016/j.ydbio.2018.04.021
Epub:
Yes
Abstract:
Internal organs exhibit left-right asymmetric sizes, shapes and anatomical positions, but how these different lateralities...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160617306759
Organism or Cell Type:
Xenopus
Citation Extract:
Womble M, Amin NM, Nascone-Yoder N. The left-right asymmetry of liver lobation is generated by Pitx2c-mediated asymmetries in the hepatic diverticulum. Dev Biol. 2018;[Epub] doi:10.1016/j.ydbio.2018.04.021.

Scaling up to study brca2: the zeppelin zebrafish mutant reveals a role for brca2 in embryonic development of kidney mesoderm

Authors:
Drummond BE, Wingert RA
Citation:
Cancer Cell Microenviron. 2018;5(1). pii: e1630. doi: 10.14800/ccm.1630. Epub 2018 Apr 9
Epub:
Not Epub
Abstract:
Specialized renal epithelial cells known as podocytes are essential components of the filtering structures within the kidney...
Link:
https://www.smartscitech.com/index.php/CCM/article/view/1630
Citation Extract:
Drummond BE, Wingert RA. Scaling up to study brca2: the zeppelin zebrafish mutant reveals a role for brca2 in embryonic development of kidney mesoderm. Cancer Cell Microenviron. 2018;5(1). pii: e1630. doi: 10.14800/ccm.1630. Epub 2018 Apr 9.

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