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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina
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Citation:
Front Cell Dev Biol. 2023;11:1142586. doi:10.3389/fcell.2023.1142586 Epub:
Not Epub Abstract:
Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated... Delivery Method:
intravitreal (intraocular) injection then electroporation Organism or Cell Type:
zebrafish Citation Extract: Boyd P, Campbell LJ, Hyde DR. Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina. Front Cell Dev Biol. 2023;11:1142586. doi:10.3389/fcell.2023.1142586. |
Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes
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Citation:
Blood. 2023;141(6):645-58. doi:10.1182/blood.2022016783 Epub:
Not Epub Abstract:
The mechanisms of coordinated changes in proteome composition and their relevance for the differentiation of neutrophil... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Linder MI, Mizoguchi Y, Hesse S, Csaba G, Tatematsu M, Łyszkiewicz M, Ziȩtara N, Jeske T, Hastreiter M, Rohlfs M, Liu Y, Grabowski P, Ahomaa K, Maier-Begandt D, Schwestka M, Pazhakh V, Isiaku AI, Miranda BB, Blombery P, Saito MK, Rusha E, Alizadeh Z, Pourpak Z, Kobayashi M, Rezaei N, Unal E, Hauck F, Drukker M, Walzog B, Rappsilber J, Zimmer R, Lieschke GJ, Klein C. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes. Blood. 2023;141(6):645-58. doi:10.1182/blood.2022016783. |
Converging Role for REEP1/SPG31 in Oxidative Stress
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Citation:
Int J Mol Sci. 2023;24(4):3527. doi:10.3390/ijms24043527 Epub:
Not Epub Abstract:
Mutations in the receptor expression-enhancing protein 1 gene (REEP1) are associated with hereditary spastic paraplegia type 31... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Naef V, Meschini MC, Tessa A, Morani F, Corsinovi D, Ogi A, Marchese M, Ori M, Santorelli FM, Doccini S. Converging Role for REEP1/SPG31 in Oxidative Stress. Int J Mol Sci. 2023;24(4):3527. doi:10.3390/ijms24043527. |
Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: study protocol for a phase I/II clinical trial
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Citation:
medRxiv. 2023;[preprint] doi:10.1101/2023.02.06.23285500 Epub:
Not Epub Abstract:
Aim: The purpose of this study is to evaluate the safety and pharmacokinetics of the novel morpholino oligomer NS-089/NCNP-02... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Ishizuka T, Komaki H, Asahina Y, Nakamura H, Motohashi N, Takeshita E, Motohashi Y, Ishiyama A, Yonee C, Maruyama S, Hida E, Aoki Y. Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: study protocol for a phase I/II clinical trial. medRxiv. 2023;[preprint] doi:10.1101/2023.02.06.23285500 . |
Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration
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Citation:
Int J Mol Sci. 2023;24(4):3253. doi:10.3390/ijms24043253 Epub:
Not Epub Abstract:
In contrast to the case in mammals, the fish optic nerve can spontaneously regenerate and visual function can be fully restored... Delivery Method:
Vivo-Morpholino intraocular injection Organism or Cell Type:
zebrafish Citation Extract: Sugitani K, Mokuya T, Homma S, Maeda M, Konno A, Ogai K. Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. Int J Mol Sci. 2023;24(4):3253. doi:10.3390/ijms24043253. |
Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis
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Citation:
Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212212120. doi: 10.1073/pnas.2212212120. Epub 2023 Feb 6 Epub:
Not Epub Abstract:
During vertebrate embryogenesis, hematopoietic stem and progenitor cell (HSPC) production through endothelial-to-hematopoietic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Heng J, Shi B, Zhou JY, Zhang Y, Ma D, Yang YG, Liu F. Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212212120. doi: 10.1073/pnas.2212212120. Epub 2023 Feb 6. |
Gaucher disease protects against tuberculosis
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Citation:
Proc Natl Acad Sci USA. 2023;120(7):e2217673120 doi:10.1073/pnas.2217673120 Epub:
Not Epub Abstract:
Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Fan J, Hale VL, Lelieveld LT, Ramakrishna L. Gaucher disease protects against tuberculosis. Proc Natl Acad Sci USA. 2023;120(7):e2217673120 doi:10.1073/pnas.2217673120. |
Ubiquitylation of BBSome is required for ciliary assembly and signaling
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Citation:
Ubiquitylation of BBSome is required for ciliary assembly and signaling. EMBO Rep. 2023 Feb 6:e55571. doi:10.15252/embr.202255571. Online ahead of print Epub:
Yes Abstract:
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, renal abnormalities, postaxial... Delivery Method:
microinjection Organism or Cell Type:
Oryzias latipes (medaka fish) Citation Extract: Chiuso F, Delle Donne R, Giamundo G, Rinaldi L, Borzacchiello D, Moraca F, Intartaglia D, Iannucci R, Senatore E, Lignitto L, Garbi C, Conflitti P, Catalanotti B, Conte I, Feliciello A. Ubiquitylation of BBSome is required for ciliary assembly and signaling. Ubiquitylation of BBSome is required for ciliary assembly and signaling. EMBO Rep. 2023 Feb 6:e55571. doi:10.15252/embr.202255571. Online ahead of print. |
Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs
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Citation:
J Am Soc Nephrol. 2022 Nov 22:ASN.2022010050. doi: 10.1681/ASN.2022010050. Online ahead of print Epub:
Yes Abstract:
Background About 40 disease genes have been described to date for isolated congenital anomalies of the kidneys and urinary... Organism or Cell Type:
Xenopus Citation Extract: Klämbt V, Buerger F, Wang C, Naert T, Richter K, Nauth T, Weiss AC, Sieckmann T, Lai E, Connaughton D, Seltzsam S, Mann N, Majmundar A, Wu CH, Onuchic-Whitford A, Shril S, Schneider S, Schierbaum L, Dai R, Bekheirnia MR, Joosten M, Shlomovitz O, Vivante A, Banne E, Mane S, Lifton RP, Kirschner K, Kispert A, Rosenberger G, Fischer KD, Lienkamp S, Zegers M, Hildebrandt F . Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. J Am Soc Nephrol. 2022 Nov 22:ASN.2022010050. doi: 10.1681/ASN.2022010050. Online ahead of print. |
Confined environments induce polarized paraspeckle condensates
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Citation:
Commun Biol 6, 145 (2023). doi:10.1038/s42003-023-04528-4 Epub:
Not Epub Abstract:
Cancer cells experience confinement as they navigate the tumour microenvironment during metastasis. Recent studies have... Delivery Method:
electroporation Organism or Cell Type:
cell culture: MDA-MB-231 human breast cancer cells Citation Extract: Todorovski V, McCluggage F, Li Y, Meid A, Spatz JP, Holle AW, Fox AH, Choi Y. Confined environments induce polarized paraspeckle condensates. Commun Biol 6, 145 (2023). doi:10.1038/s42003-023-04528-4. |