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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12221 scientific papers returned from the database with the search filters currently being used below.

An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier

Authors:
Chang WW, Matt A-S, Schewe M, Musinszki M, Grüssel S, Brandenburg J, Garfield D, Bleich M, Baukrowitz T, Hu MY
Citation:
Proc Nat Acad Sci USA. 2021;118(30):e2101378118. doi:10.1073/pnas.2101378118
Epub:
Not Epub
Abstract:
Otopetrins comprise a family of proton-selective channels that are critically important for the mineralization of otoliths and...
Link:
https://www.pnas.org/content/118/30/e2101378118.full
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Chang WW, Matt A-S, Schewe M, Musinszki M, Grüssel S, Brandenburg J, Garfield D, Bleich M, Baukrowitz T, Hu MY. An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier. Proc Nat Acad Sci USA. 2021;118(30):e2101378118. doi:10.1073/pnas.2101378118.

MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes

Authors:
Liu X, Xu F, Ren L, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J, Guo F
Citation:
Nat Commun. 2021;12:4427. doi:10.1038/s41467-021-24724-2
Epub:
Not Epub
Abstract:
The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the stability of various cellular membrane...
Link:
https://www.nature.com/articles/s41467-021-24724-2
Delivery Method:
intranasal Vivo-Morpholino
Organism or Cell Type:
C57Bl/6 mice
Citation Extract:
Liu X, Xu F, Ren L, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J, Guo F. MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes. Nat Commun. 2021;12:4427. doi:10.1038/s41467-021-24724-2.

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Authors:
Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Phadke K-S, Zhang G, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Verhoeven DE, Pentelute BL
Citation:
Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4
Epub:
Not Epub
Abstract:
Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine...
Link:
https://www.nature.com/articles/s41467-021-24598-4
Delivery Method:
cell bathing
Organism or Cell Type:
cell culture: Vero-E6 & SARS-CoV-2
Citation Extract:
Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Phadke K-S, Zhang G, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Verhoeven DE, Pentelute BL. Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers. Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4.

Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations

Authors:
Qi H, Schmöhl F, Li X, Qian X, Tabler CT, Bennewitz K, Sticht C, Morgenstern J, Fleming T, Volk N, Hausser I, Heidenreich E, Hell R, Nawroth PP, Kroll J
Citation:
Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281
Epub:
Not Epub
Abstract:
Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202101281
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Qi H, Schmöhl F, Li X, Qian X, Tabler CT, Bennewitz K, Sticht C, Morgenstern J, Fleming T, Volk N, Hausser I, Heidenreich E, Hell R, Nawroth PP, Kroll J. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281.

Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae

Authors:
Lin CH, Hu HJ, Chuang HJ, Tsou YL, Hwang PP
Citation:
J Comp Physiol B. 2021 Jul 17. doi: 10.1007/s00360-021-01390-w. Online ahead of print
Epub:
Not Epub
Abstract:
Freshwater fish live in environments where pH levels fluctuate more than those in seawater. During acidic stress, the acid-base...
Link:
https://link.springer.com/article/10.1007%2Fs00360-021-01390-w
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Lin CH, Hu HJ, Chuang HJ, Tsou YL, Hwang PP. Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae. J Comp Physiol B. 2021 Jul 17. doi: 10.1007/s00360-021-01390-w. Online ahead of print.

Morpholino-driven transcriptional blockade of Dkk-1 in experimental osteosarcoma inhibits bone damage and tumor expansion by multiple mechanisms

Authors:
Pan S, Cesarek M, Godoy C, Co C, Schindler C, Padilla K, Poole R, Dabney A, Gregory C
Citation:
Res Sq. 2021;[preprint] doi:10.21203/rs.3.rs-677459/v1
Epub:
Not Epub
Abstract:
Osteosarcoma (OS) is the most common primary bone malignancy. Chemotherapy plays an essential role in OS treatment, potentially...
Link:
https://www.researchsquare.com/article/rs-677459/v1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: (RFP)-labeled MOSJ-Dkk1 murine osteochondral sarcoma line, xenograft in Foxn1-/Foxn1- mice
Citation Extract:
Pan S, Cesarek M, Godoy C, Co C, Schindler C, Padilla K, Poole R, Dabney A, Gregory C. Morpholino-driven transcriptional blockade of Dkk-1 in experimental osteosarcoma inhibits bone damage and tumor expansion by multiple mechanisms. Res Sq. 2021;[preprint] doi:10.21203/rs.3.rs-677459/v1.

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

Authors:
Boeckel J-N, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B
Citation:
Genomics Proteomics Bioinformatics. 2021;[Epub ahead of print] doi:10.1016/j.gpb.2021.01.006
Epub:
Yes
Abstract:
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing...
Link:
https://www.sciencedirect.com/science/article/pii/S1672022921001467
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boeckel J-N, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B. SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy. Genomics Proteomics Bioinformatics. 2021;[Epub ahead of print] doi:10.1016/j.gpb.2021.01.006.

The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis

Authors:
DeJong CS, Dichmann DS, Exner CRT, Xu Y, Harland RM
Citation:
Development. 2021 Aug 1;148(15):dev191619. doi: 10.1242/dev.191619. Epub 2021 Aug 4. PMID: 34345915; PMCID: PMC8353262
Epub:
Not Epub
Abstract:
The FET family of atypical RNA-binding proteins includes Fused in sarcoma (FUS), Ewing's sarcoma (EWS) and the TATA-...
Link:
https://journals.biologists.com/dev/article/148/15/dev191619/271175/The-atypical-RNA-binding-protein-Taf15-regulates
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
DeJong CS, Dichmann DS, Exner CRT, Xu Y, Harland RM. The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis. Development. 2021 Aug 1;148(15):dev191619. doi: 10.1242/dev.191619. Epub 2021 Aug 4. PMID: 34345915; PMCID: PMC8353262.

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Authors:
Thomas C, Wetherall B, Levasseur D, Harris RJ, Kerridge ST, Higgins JMG, Davies OR, Madgwick S
Citation:
Nat Commun. 2021;12(1):4322. doi:10.1038/s41467-021-24554-2
Epub:
Not Epub
Abstract:
Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase,...
Link:
https://www.nature.com/articles/s41467-021-24554-2
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Thomas C, Wetherall B, Levasseur D, Harris RJ, Kerridge ST, Higgins JMG, Davies OR, Madgwick S. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes. Nat Commun. 2021;12(1):4322. doi:10.1038/s41467-021-24554-2.

Real time large scale in vivo observations by light-sheet microscopy reveal intrinsic synchrony, plasticity and growth cone dynamics of midline crossing axons at the ventral floor plate of the zebrafish spinal cord

Authors:
Andersen SSL
Citation:
arXiv. 2021;2107.05242v1 [preprint]
Epub:
Not Epub
Abstract:
Axonal growth and guidance at the ventral floor plate is here followed in vivo in real time at high resolution by light-sheet...
Link:
https://arxiv.org/abs/2107.05242
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Andersen SSL. Real time large scale in vivo observations by light-sheet microscopy reveal intrinsic synchrony, plasticity and growth cone dynamics of midline crossing axons at the ventral floor plate of the zebrafish spinal cord. arXiv. 2021;2107.05242v1 [preprint].

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