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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12221 scientific papers returned from the database with the search filters currently being used below.

A recurrent missense variant in EYA3 gene is associated with oculo-auriculo-vertebral spectrum

Authors:
Tingaud-Sequeira A, Trimouille A, Salaria M, Stapleton R, Claverol S, Plaisant C, Bonneu M, Lopez E, Arveiler B, Lacombe D, Rooryck C
Citation:
Hum Genet. 2021;[Epub ahead of print] doi:s00439-021-02255-6
Epub:
Yes
Abstract:
Goldenhar syndrome or oculo-auriculo-vertebral spectrum (OAVS) is a complex developmental disorder characterized by asymmetric...
Link:
https://link.springer.com/article/10.1007%2Fs00439-021-02255-6
Organism or Cell Type:
zebrafish
Citation Extract:
Tingaud-Sequeira A, Trimouille A, Salaria M, Stapleton R, Claverol S, Plaisant C, Bonneu M, Lopez E, Arveiler B, Lacombe D, Rooryck C. A recurrent missense variant in EYA3 gene is associated with oculo-auriculo-vertebral spectrum. Hum Genet. 2021;[Epub ahead of print] doi:s00439-021-02255-6.

LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and visual function in zebrafish

Authors:
Guo R, Ge K, Wang Y, Lu M, Li F, Tian L, Gan L, Sheng D
Citation:
Sci Rep. 2021;11:1977. doi:10.1038/s41598-021-81211-w
Epub:
Not Epub
Abstract:
LIM homeobox 4 (LHX4) is expressed in the photoreceptors (PRs) of the outer nuclear layer (ONL) and bipolar cells (BCs) of the...
Link:
https://www.nature.com/articles/s41598-021-81211-w
Delivery Method:
microinjection, Vivo-Morpholino (ocular injection)
Organism or Cell Type:
zebrafish
Citation Extract:
Guo R, Ge K, Wang Y, Lu M, Li F, Tian L, Gan L, Sheng D. LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and visual function in zebrafish. Sci Rep. 2021;11:1977. doi:10.1038/s41598-021-81211-w.

Functional Role of the RNA-Binding Protein Rbm24a and Its Target sox2 in Microphthalmia

Authors:
Brastrom LK, Scott CA, Wang K, Slusarski DC
Citation:
Biomedicines. 2021;9(2):100. doi:10.3390/biomedicines9020100
Epub:
Not Epub
Abstract:
Congenital eye defects represent a large class of disorders affecting roughly 21 million children worldwide. Microphthalmia and...
Link:
https://www.mdpi.com/2227-9059/9/2/100
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brastrom LK, Scott CA, Wang K, Slusarski DC. Functional Role of the RNA-Binding Protein Rbm24a and Its Target sox2 in Microphthalmia. Biomedicines. 2021;9(2):100. doi:10.3390/biomedicines9020100.

Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos

Authors:
Cafora M, Forti F, Briani F, Ghisotti D, Pistocchi A
Citation:
J Vis Exp. 2020;(159):e61275. doi:10.3791/61275
Epub:
Not Epub
Abstract:
Antimicrobial resistance, a major consequence of diagnostic uncertainty and antimicrobial overprescription, is an increasingly...
Link:
https://www.jove.com/t/61275/phage-therapy-application-to-counteract-pseudomonas-aeruginosa
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cafora M, Forti F, Briani F, Ghisotti D, Pistocchi A. Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos. J Vis Exp. 2020;(159):e61275. doi:10.3791/61275 .

An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy

Authors:
Pagnamenta AT, Kaiyrzhanov R, Zou Y, Da'as SI, Maroofian R, Donkervoort S, Dominik N, Lauffer M, Ferla MP, Orioli A, Giess A, Tucci A, Beetz C, Sedghi M, Ansari B, Barresi R, Basiri K, Cortese A, Elgar G, Fernandez-Garcia MA, Yip J, Foley AR, Gutowski N, Jungbluth H, Lassche S, Lavin T, Marcelis C, Marks P, Marini-Bettolo C, Medne L, Moslemi A-R, Sarkozy A, Reilly MM, Muntoni F, Millan F, Muraresku CC, Need AC, Nemeth AH, Neuhaus SB, Norwood F, O'Donnell M, O’Driscoll M, Rankin J, Yum SW, Zolkipli-Cunningham Z, Brusius I, Wunderlich G, Genomics England Research Consortium, Karakaya M, Wirth B, Fakhro KA, Tajsharghi H, Bönnemann CG, Taylor JC, Houlden H
Citation:
Brain. 2021;[Epub ahead of print] doi:10.1093/brain/awaa420
Epub:
Yes
Abstract:
The extracellular matrix comprises a network of macromolecules such as collagens, proteoglycans and glycoproteins. VWA1 (von...
Link:
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaa420/6103826
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pagnamenta AT, Kaiyrzhanov R, Zou Y, Da'as SI, Maroofian R, Donkervoort S, Dominik N, Lauffer M, Ferla MP, Orioli A, Giess A, Tucci A, Beetz C, Sedghi M, Ansari B, Barresi R, Basiri K, Cortese A, Elgar G, Fernandez-Garcia MA, Yip J, Foley AR, Gutowski N, Jungbluth H, Lassche S, Lavin T, Marcelis C, Marks P, Marini-Bettolo C, Medne L, Moslemi A-R, Sarkozy A, Reilly MM, Muntoni F, Millan F, Muraresku CC, Need AC, Nemeth AH, Neuhaus SB, Norwood F, O'Donnell M, O’Driscoll M, Rankin J, Yum SW, Zolkipli-Cunningham Z, Brusius I, Wunderlich G, Genomics England Research Consortium, Karakaya M, Wirth B, Fakhro KA, Tajsharghi H, Bönnemann CG, Taylor JC, Houlden H. An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy. Brain. 2021;[Epub ahead of print] doi:10.1093/brain/awaa420.

A regulatory sub-circuit downstream of Wnt signaling controls developmental transitions in neural crest formation

Authors:
Azambuja AP, Simoes-Costa M
Citation:
PLoS Genet. 2021;17(1):e1009296. doi:10.1371/journal.pgen.1009296
Epub:
Not Epub
Abstract:
The process of cell fate commitment involves sequential changes in the gene expression profiles of embryonic progenitors. This...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009296
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Azambuja AP, Simoes-Costa M. A regulatory sub-circuit downstream of Wnt signaling controls developmental transitions in neural crest formation. PLoS Genet. 2021;17(1):e1009296. doi:10.1371/journal.pgen.1009296.

Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model

Authors:
Lu-Nguyen N, Malerba A, Herath S, Dickson G, Popplewell L
Citation:
Hum Mol Genet. 2021 Jul 9;30(15):1398-1412. doi: 10.1093/hmg/ddab136. PMID: 33987655; PMCID: PMC8283208
Epub:
Not Epub
Abstract:
Aberrant expression of the double homeobox 4 (DUX4) gene in skeletal muscle causes muscle deterioration and weakness in...
Link:
https://academic.oup.com/hmg/article/30/15/1398/6275367
Delivery Method:
Endo-Porter, Vivo-Morpholino
Organism or Cell Type:
cell culture, mice
Citation Extract:
Lu-Nguyen N, Malerba A, Herath S, Dickson G, Popplewell L. Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model. Hum Mol Genet. 2021 Jul 9;30(15):1398-1412. doi: 10.1093/hmg/ddab136. PMID: 33987655; PMCID: PMC8283208.

The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus

Authors:
Bhuiyan MS, Jiang J-H, Kostoulias X, Theegala R, Lieschke GJ, Peleg AY
Citation:
Antibiotics. 2021;10(2):96. doi:10.3390/antibiotics10020096
Epub:
Not Epub
Abstract:
Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of...
Link:
https://www.mdpi.com/2079-6382/10/2/96
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bhuiyan MS, Jiang J-H, Kostoulias X, Theegala R, Lieschke GJ, Peleg AY. The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus. Antibiotics. 2021;10(2):96. doi:10.3390/antibiotics10020096.

Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish

Authors:
Facchinello N, Laquatra C, Locatello L, Beffagna G, Brañas Casas R, Fornetto C, Dinarello A, Martorano L, Vettori A, Risato G, Celeghin R, Meneghetti G, Santoro MM, Delahodde A, Vanzi F, Rasola A, Dalla Valle L, Rasotto MB, Lodi T, Baruffini E, Argenton F, Tiso N
Citation:
Cell Death Dis. 2021 Jan 19;12(1):100. doi: 10.1038/s41419-020-03359-z
Epub:
Not Epub
Abstract:
The DNA polymerase gamma (Polg) is a nuclear-encoded enzyme involved in DNA replication in animal mitochondria. In humans,...
Link:
https://www.nature.com/articles/s41419-020-03359-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Facchinello N, Laquatra C, Locatello L, Beffagna G, Brañas Casas R, Fornetto C, Dinarello A, Martorano L, Vettori A, Risato G, Celeghin R, Meneghetti G, Santoro MM, Delahodde A, Vanzi F, Rasola A, Dalla Valle L, Rasotto MB, Lodi T, Baruffini E, Argenton F, Tiso N. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death Dis. 2021 Jan 19;12(1):100. doi: 10.1038/s41419-020-03359-z.

Rab11fip5 regulates telencephalon development via ephrinB1 recycling

Authors:
Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO
Citation:
Development. 2021 Jan 18:dev.196527. doi: 10.1242/dev.196527. Online ahead of print
Epub:
Yes
Abstract:
Rab11 family-interacting protein 5 (Rab11fip5) is an adaptor protein that binds to the small GTPase Rab11, which has an...
Link:
https://dev.biologists.org/content/early/2021/01/15/dev.196527
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO. Rab11fip5 regulates telencephalon development via ephrinB1 recycling. Development. 2021 Jan 18:dev.196527. doi: 10.1242/dev.196527. Online ahead of print.

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