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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12318 scientific papers returned from the database with the search filters currently being used below.
There are 12318 scientific papers returned from the database with the search filters currently being used below.
Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa
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Citation:
EBioMedicine. 2020;56:102792. doi:10.1016/j.ebiom.2020.102792 Epub:
Not Epub Abstract:
Background: Retinitis pigmentosa (RP) is the most common form of inherited retinal degeneration, but genetic defects in nearly... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yi Z, Ouyang J, Sun W, Li S, Xiao X, Zhang Q. Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa. EBioMedicine. 2020;56:102792. doi:10.1016/j.ebiom.2020.102792. |
A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia
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Citation:
Research Square. 2020;[preprint]. doi:10.21203/rs.3.rs-34665/v1 Epub:
Not Epub Abstract:
Background: Polo-like kinases (PLKs) are conserved serine/threonine kinase, regulating cell cycle. Giardia lamblia PLK (GlPLK)... Delivery Method:
electroporation Organism or Cell Type:
Giardia lamblia Citation Extract: Park E-A, Kim J, Shin MY, Park S-J. A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia. Research Square. 2020;[preprint]. doi:10.21203/rs.3.rs-34665/v1. |
Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos
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Citation:
Front Cell Dev Biol. 2020;8:831. doi:10.3389/fcell.2020.00381 Epub:
Not Epub Abstract:
High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and embryogenesis and correlate with fertility of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Otten ABC, Kamps R, Lindsey P, Gerards M, Pendeville-Samain H, Muller M, van Tienen FHJ, Smeets HJM. Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos. Front Cell Dev Biol. 2020;8:831. doi:10.3389/fcell.2020.00381. |
Use Of Non-Ablative Dose Of Radiation To Enhance Delivery Of Unmodified Morpholino Oligonucleotides In A Brain Tumor Model To Silence MGMT And Enhance The Efficacy Of Chemo-Radiation (4281)
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Citation:
Neurology. 2020;94 (15 Supplement) Epub:
Not Epub Abstract:
Objective: Non-ablative Ionizing radiation ( XRT) is well known to alter neuro-vascular unit (NVU) permeability. We evaluate... Delivery Method:
injection and ionizing radiation Organism or Cell Type:
Intracranial tumor bearing athymic nude rats Citation Extract: Ambady P, Wu J, Walker J, Kersch C, Morris DA, Bills J, Holland S, Pagel M, Muldoon L, Neuwelt E. Use Of Non-Ablative Dose Of Radiation To Enhance Delivery Of Unmodified Morpholino Oligonucleotides In A Brain Tumor Model To Silence MGMT And Enhance The Efficacy Of Chemo-Radiation (4281). Neurology. 2020;94 (15 Supplement). |
Energy and nitrogenous waste from glutamate/glutamine catabolism facilitates acute osmotic adjustment in non-neuroectodermal branchial cells
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Citation:
Sci Rep. 2020;10:9460. doi:10.1038/s41598-020-65913-1 Epub:
Not Epub Abstract:
Maintenance of homeostasis is one of the most important physiological responses for animals upon osmotic perturbations.... Delivery Method:
microinjection Organism or Cell Type:
Oryzias latipes (medaka) Citation Extract: Huang P, Liu T, Hu MY, Casties I, Tseng Y-C. Energy and nitrogenous waste from glutamate/glutamine catabolism facilitates acute osmotic adjustment in non-neuroectodermal branchial cells. Sci Rep. 2020;10:9460. doi:10.1038/s41598-020-65913-1. |
Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model
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Citation:
Methods Mol Biol. 2020;2152:225-251. doi: 10.1007/978-1-0716-0640-7_17 Epub:
Not Epub Abstract:
The use of vertebrate models allows researchers to investigate mechanisms of CCM pathogenesis in vivo, to investigate... Organism or Cell Type:
zebrafish Citation Extract: Abou-Fadel J, Zhang J. Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model. Methods Mol Biol. 2020;2152:225-251. doi: 10.1007/978-1-0716-0640-7_17. |
Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network
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Citation:
Front Cardiovasc Med. 2022 Mar 18;9:841101. doi: 10.3389/fcvm.2022.841101. PMID: 35369301; PMCID: PMC8971683 Epub:
Not Epub Abstract:
Mechano-responsive signaling pathways enable blood vessels within a connected network to structurally adapt to partition of... Link:
Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Baek KI, Chang SS, Chang CC, Roustaei M, Ding Y, Wang Y, Chen J, O'Donnell R, Chen H, Ashby JW, Xu X, Mack JJ, Cavallero S, Roper M, Hsiai TK. Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network. Front Cardiovasc Med. 2022 Mar 18;9:841101. doi: 10.3389/fcvm.2022.841101. PMID: 35369301; PMCID: PMC8971683. |
Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome
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Citation:
Elife. 2020 Oct 2;9:e59554. doi: 10.7554/eLife.59554. PMID: 33006316; PMCID: PMC7581429 Epub:
Not Epub Abstract:
Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Theis JL, Vogler G, Missinato MA, Li X, Nielsen T, Zeng XI, Martinez-Fernandez A, Walls SM, Kervadec A, Kezos JN, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Nelson TJ, Olson TM, Colas AR, Bodmer R. Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome. Elife. 2020 Oct 2;9:e59554. doi: 10.7554/eLife.59554. PMID: 33006316; PMCID: PMC7581429. |
Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells
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Citation:
Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa490 Epub:
Not Epub Abstract:
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: human primary bronchial epithelial cells Citation Extract: Michaels WE, Bridges RJ, Hastings ML. Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells. Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa490. |
Viltolarsen: First Approval
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Citation:
Drugs. 2020 Jun 9. doi: 10.1007/s40265-020-01339-3. Online ahead of print Epub:
Yes Abstract:
Viltolarsen (Viltepso® in Japan) is a phosphorodiamidate morpholino antisense oligonucleotide being developed by Nippon... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Dhillon S. Viltolarsen: First Approval. Drugs. 2020 Jun 9. doi: 10.1007/s40265-020-01339-3. Online ahead of print. |