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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12321 scientific papers returned from the database with the search filters currently being used below.

Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis

Authors:
Kyritsi K, Francis H, Zhou T, Ceci L, Wu N, Yhang Z, Meng F, Chen L, Baiocchi L, Kundu D, Kennedy L, Liangpunsakul S, Wu C, Glaser S, Alpini G
Citation:
Gene Expr. 2020 May 11. doi: 10.3727/105221620X15889714507961. [Epub ahead of print]
Epub:
Yes
Abstract:
Biliary senescence and hepatic fibrosis are hallmarks of cholangiopathies including primary sclerosing cholangitis (PSC)....
Link:
https://www.ingentaconnect.com/content/cog/ge/pre-prints/content-ge-000610
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Kyritsi K, Francis H, Zhou T, Ceci L, Wu N, Yhang Z, Meng F, Chen L, Baiocchi L, Kundu D, Kennedy L, Liangpunsakul S, Wu C, Glaser S, Alpini G. Downregulation of p16 decreases biliary damage and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis. Gene Expr. 2020 May 11. doi: 10.3727/105221620X15889714507961. [Epub ahead of print].

The micropeptide LEMP plays an evolutionarily conserved role in myogenesis

Authors:
Wang L, Fan J, Han L, Qi H, Wang Y, Wang H, Chen S, Du L, Li S, Zhang Y, Tang W, Ge G, Pan W, Hu P, Cheng H
Citation:
Cell Death Dis. 2020;11:357. doi:10.1038/s41419-020-2570-5
Epub:
Not Epub
Abstract:
In recent years, micropeptides have been increasingly identified as important regulators in various biological processes....
Link:
https://www.nature.com/articles/s41419-020-2570-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang L, Fan J, Han L, Qi H, Wang Y, Wang H, Chen S, Du L, Li S, Zhang Y, Tang W, Ge G, Pan W, Hu P, Cheng H. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis. 2020;11:357. doi:10.1038/s41419-020-2570-5.

Effective Pseudo-Exon Skipping of a COL6A1 Intronic Mutation in Cultured Muscle Interstitial Fibroblasts from a Novel Humanized Mouse Model

Authors:
Bolduc V, Guirguis F, Aguti S, Zhou H, Cheng J, Garrett L, Muntoni F, Bönnemann CG
Citation:
Molec Ther. 2020;28(4S1):401. abstract 925. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Collagen VI-related dystrophies (COL6-RDs) are a group of frequently severe, congenital-onset muscular dystrophies for which...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Bolduc V, Guirguis F, Aguti S, Zhou H, Cheng J, Garrett L, Muntoni F, Bönnemann CG. Effective Pseudo-Exon Skipping of a COL6A1 Intronic Mutation in Cultured Muscle Interstitial Fibroblasts from a Novel Humanized Mouse Model. Molec Ther. 2020;28(4S1):401. abstract 925. doi:10.1016/j.ymthe.2020.04.019.

A Reversible RNA On-Switch That Controls Expression of Aav-Delivered Transgenes In Vivo

Authors:
Zhong G, Wang H, Farzan M
Citation:
Molec Ther. 2020;28(4S1):224. abstract 510. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Zhong G, Wang H, Farzan M. A Reversible RNA On-Switch That Controls Expression of Aav-Delivered Transgenes In Vivo. Molec Ther. 2020;28(4S1):224. abstract 510. doi:10.1016/j.ymthe.2020.04.019.

Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes

Authors:
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL
Citation:
Toxicol Sci. 2020 May 8. pii: kfaa063. doi: 10.1093/toxsci/kfaa063. [Epub ahead of print]
Epub:
Yes
Abstract:
The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic...
Link:
https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfaa063/5834730
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL. Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicol Sci. 2020 May 8. pii: kfaa063. doi: 10.1093/toxsci/kfaa063. [Epub ahead of print].

Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching

Authors:
Marchalot A, Ashi MO, Lambert JM, Carrion C, Lecardeur S, Srour N, Delpy L, Le Pennec S
Citation:
Front Immunol. 2020;11:780. doi:10.3389/fimmu.2020.00780
Epub:
Not Epub
Abstract:
Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located...
Link:
https://www.frontiersin.org/articles/10.3389/fimmu.2020.00780/full
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: murine splenic B cells
Citation Extract:
Marchalot A, Ashi MO, Lambert JM, Carrion C, Lecardeur S, Srour N, Delpy L, Le Pennec S. Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching. Front Immunol. 2020;11:780. doi:10.3389/fimmu.2020.00780.

Composition-dependent thermodynamics of intracellular phase separation

Authors:
Riback JA, Zhu L, Ferrolino MC, Tolbert M, Mitrea DM, Sanders DW, Wei M-T, Kriwacki RW, Brangwynne CP
Citation:
Nature. 2020;[Epub]. doi:10.1038/s41586-020-2256-2
Epub:
Yes
Abstract:
Intracellular bodies such as nucleoli, Cajal bodies and various signalling assemblies represent membraneless organelles, or...
Link:
https://www.nature.com/articles/s41586-020-2256-2
Citation Extract:
Riback JA, Zhu L, Ferrolino MC, Tolbert M, Mitrea DM, Sanders DW, Wei M-T, Kriwacki RW, Brangwynne CP. Composition-dependent thermodynamics of intracellular phase separation. Nature. 2020;[Epub]. doi:10.1038/s41586-020-2256-2.

Knocking-down of the Prokineticin receptor 2 affects reveals its complex role in the regulation of the hypothalamus-pituitary-gonadal axis in the zebrafish model

Authors:
Bassi I, Luzzani F, Marelli F, Vezzoli V, Cotellessa L, Prober DA, Persani L, Gothilf Y, Bonomi M
Citation:
Sci Rep. 2020;10(1):7632 doi:10.1038/s41598-020-64077-2
Epub:
Not Epub
Abstract:
Prokineticin receptors (PROKR1 and PROKR2) are G protein-coupled receptors which control human central and peripheral...
Link:
https://www.nature.com/articles/s41598-020-64077-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bassi I, Luzzani F, Marelli F, Vezzoli V, Cotellessa L, Prober DA, Persani L, Gothilf Y, Bonomi M. Knocking-down of the Prokineticin receptor 2 affects reveals its complex role in the regulation of the hypothalamus-pituitary-gonadal axis in the zebrafish model. Sci Rep. 2020;10(1):7632 doi:10.1038/s41598-020-64077-2.

Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism

Authors:
Yin H-M, Yan L-F, Liu Q, Peng Z, Zhang C-Y, Xia Y, Su D, Gu A-H, Zhou Y
Citation:
Sci Adv. 2020;6(19):eaay9466 doi:10.1126/sciadv.aay9466
Epub:
Not Epub
Abstract:
The cardiac and hematopoietic progenitors (CPs and HPs, respectively) in the mesoderm ultimately form a well-organized...
Link:
https://advances.sciencemag.org/content/6/19/eaay9466
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yin H-M, Yan L-F, Liu Q, Peng Z, Zhang C-Y, Xia Y, Su D, Gu A-H, Zhou Y. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Sci Adv. 2020;6(19):eaay9466 doi:10.1126/sciadv.aay9466.

The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled

Authors:
Kratzer MC, Becker SFS, Grund A, Merks A, Harnoš J, Bryja V, Giehl K, Kashef J, Borchers A
Citation:
Development. 2020 May 4. pii: dev.186338. doi: 10.1242/dev.186338. [Epub ahead of print]
Epub:
Yes
Abstract:
Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to...
Link:
https://dev.biologists.org/content/early/2020/05/01/dev.186338.long
Organism or Cell Type:
Xenopus
Citation Extract:
Kratzer MC, Becker SFS, Grund A, Merks A, Harnoš J, Bryja V, Giehl K, Kashef J, Borchers A. The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled. Development. 2020 May 4. pii: dev.186338. doi: 10.1242/dev.186338. [Epub ahead of print].

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