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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12420 scientific papers returned from the database with the search filters currently being used below.

The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish

Authors:
Jiménez-Amilburu V, Stainier DYR
Citation:
Development. 2019;[Epub ahead of print] doi:10.1242/dev.171207
Epub:
Yes
Abstract:
Tissue morphogenesis requires changes in cell-cell adhesion as well as in cell shape and polarity. Cardiac trabeculation is a...
Link:
http://dev.biologists.org/content/early/2019/04/11/dev.171207
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jiménez-Amilburu V, Stainier DYR. The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish. Development. 2019;[Epub ahead of print] doi:10.1242/dev.171207.

Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis

Authors:
Mills A, Bearce E, Cella R, Kim SW, Selig M, Lee S, Lowery LA
Citation:
Front Physiol. 2019;10:431 doi:10.3389/fphys.2019.00431
Epub:
Not Epub
Abstract:
Wolf-Hirschhorn Syndrome (WHS) is a human developmental disorder arising from a hemizygous perturbation, typically a...
Link:
https://www.frontiersin.org/articles/10.3389/fphys.2019.00431/full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Mills A, Bearce E, Cella R, Kim SW, Selig M, Lee S, Lowery LA. Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis. Front Physiol. 2019;10:431 doi:10.3389/fphys.2019.00431.

Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development

Authors:
Hernandez JA, Castro VL, Reyes-Nava N, Montes LP, Quintana AM
Citation:
Blood Adv. 2019;3:1244-54. doi:10.1182/bloodadvances.2018024539
Epub:
Not Epub
Abstract:
Erythropoiesis is the process by which new red blood cells (RBCs) are formed and defects in this process can lead to anemia or...
Link:
http://www.bloodadvances.org/content/3/8/1244
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hernandez JA, Castro VL, Reyes-Nava N, Montes LP, Quintana AM. Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development. Blood Adv. 2019;3:1244-54. doi:10.1182/bloodadvances.2018024539.

Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation

Authors:
Wang K, Shen Y, Yang Y, Gan X, Liu G, Hu K, Li Y, Gao Z, Zhu L, Yan G, He L, Shan X, Yang L, Lu S, Zeng H, Pan X, Liu C, Yuan Y, Feng C, Xu W, Zhu C, Xiao W, Dong Y, Wang W, Qiu Q, He S
Citation:
Nature Ecol Evol. 2019;[Epub ahead of print] doi:10.1038/s41559-019-0864-8
Epub:
Yes
Abstract:
It is largely unknown how living organisms - especially vertebrates - survive and thrive in the coldness, darkness and high...
Link:
https://www.nature.com/articles/s41559-019-0864-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang K, Shen Y, Yang Y, Gan X, Liu G, Hu K, Li Y, Gao Z, Zhu L, Yan G, He L, Shan X, Yang L, Lu S, Zeng H, Pan X, Liu C, Yuan Y, Feng C, Xu W, Zhu C, Xiao W, Dong Y, Wang W, Qiu Q, He S. Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation. Nature Ecol Evol. 2019;[Epub ahead of print] doi:10.1038/s41559-019-0864-8.

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia

Authors:
Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, de Angelis MH, Graw J
Citation:
Exp Eye Res. 2019;[Epub ahead of print] doi:10.1016/j.exer.2019.03.024
Epub:
Yes
Abstract:
During an ENU (N-ethyl-N-nitrosourea) mutagenesis screen, we observed a dominant small-eye mutant mouse with viable homozygotes...
Link:
https://www.sciencedirect.com/science/article/pii/S0014483518307024
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, de Angelis MH, Graw J. Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Exp Eye Res. 2019;[Epub ahead of print] doi:10.1016/j.exer.2019.03.024.

Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos

Authors:
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J
Citation:
Development. 2017 Feb 1;144(3):519-528. doi: 10.1242/dev.141390. Epub 2016 Dec 19
Epub:
Not Epub
Abstract:
During development from oocyte to embryo, genetic programs in mouse germ cells are reshaped by chromatin remodeling to...
Link:
http://dev.biologists.org/content/144/3/519
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J. Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos. Development. 2017 Feb 1;144(3):519-528. doi: 10.1242/dev.141390. Epub 2016 Dec 19.

Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis

Authors:
Schwenty-Lara J, Nürnberger A, Borchers A
Citation:
Dev Dyn. 2019 Apr 13. doi: 10.1002/dvdy.39. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Kabuki syndrome is a haploinsufficient congenital multi-organ malformation syndrome, which frequently includes...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/dvdy.39
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schwenty-Lara J, Nürnberger A, Borchers A. Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis. Dev Dyn. 2019 Apr 13. doi: 10.1002/dvdy.39. [Epub ahead of print].

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models

Authors:
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez‐Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao‐Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B
Citation:
EMBO Molec Med. 2019;e8734 [Epub ahead of print] doi:10.15252/emmm.201708734
Epub:
Yes
Abstract:
Mitochondrial diseases (MDs) are a heterogeneous group of devastating and often fatal disorders due to defective oxidative...
Link:
http://embomolmed.embopress.org/content/early/2019/04/12/emmm.201708734
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez‐Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao‐Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B. miR‐181a/b downregulation exerts a protective action on mitochondrial disease models. EMBO Molec Med. 2019;e8734 [Epub ahead of print] doi:10.15252/emmm.201708734.

In Ovo Electroporation of Plasmid DNA and Morpholinos into Specific Tissues During Early Embryogenesis

Authors:
McLennan R, Kulesa PM
Citation:
Neural Crest Cells. 2019. Methods in Molecular Biology (1976):71-82 Springer New York, New York, NY. doi:10.1007/978-1-4939-9412-0_6
Epub:
Not Epub
Abstract:
In ovo electroporation enables transfection of non-viral plasmid DNA and/or morpholinos to fluorescently label and/or perturb...
Link:
https://link.springer.com/protocol/10.1007/978-1-4939-9412-0_6
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
McLennan R, Kulesa PM. In Ovo Electroporation of Plasmid DNA and Morpholinos into Specific Tissues During Early Embryogenesis. Neural Crest Cells. 2019. Methods in Molecular Biology (1976):71-82 Springer New York, New York, NY. doi:10.1007/978-1-4939-9412-0_6.

Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish

Authors:
Gibson JF, Prajsnar TK, Hill CJ, Tooke AK, Serba JJ, Tonge RD, Foster SJ, Grierson AJ, Ingham PW, Renshaw SA, Johnston SA
Citation:
Autophagy. 2021 Jun;17(6):1448-1457. doi: 10.1080/15548627.2020.1765521. Epub 2020 Jun 19. PMID: 32559122; PMCID: PMC8204994
Epub:
Not Epub
Abstract:
Macroautophagy/autophagy functions to degrade cellular components and intracellular pathogens. Autophagy receptors, including...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8204994/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gibson JF, Prajsnar TK, Hill CJ, Tooke AK, Serba JJ, Tonge RD, Foster SJ, Grierson AJ, Ingham PW, Renshaw SA, Johnston SA . Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish. Autophagy. 2021 Jun;17(6):1448-1457. doi: 10.1080/15548627.2020.1765521. Epub 2020 Jun 19. PMID: 32559122; PMCID: PMC8204994.

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