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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12420 scientific papers returned from the database with the search filters currently being used below.

Loss of function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish

Authors:
Reilly ML, Stokman MF, Magry V, Jeanpierre C, Alves M, Paydar M, Hellinga J, Delous M, Pouly D, Failler M, Martinovic J, Loeuillet L, Leroy B, Tantau J, Roume J, Evans CG, Shan X, Filges I, Allingham JS, Kwok BH, Saunier S, Giles RH, Benmerah A
Citation:
Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy381
Epub:
Yes
Abstract:
Mutations in KIF14havepreviously been associated with either severe, isolated or syndromic microcephaly with renal...
Link:
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddy381/5154958
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reilly ML, Stokman MF, Magry V, Jeanpierre C, Alves M, Paydar M, Hellinga J, Delous M, Pouly D, Failler M, Martinovic J, Loeuillet L, Leroy B, Tantau J, Roume J, Evans CG, Shan X, Filges I, Allingham JS, Kwok BH, Saunier S, Giles RH, Benmerah A. Loss of function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish. Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy381.

Prmt7 regulates epiboly and gastrulation cell movements by facilitating syntenin

Authors:
Zhang W, Zhang Y, Li S, Wu Z, Yan Y, Li Y
Citation:
Acta Biochim Biophys Sin (Shanghai). 2018 Nov 1. doi: 10.1093/abbs/gmy136. [Epub ahead of print]
Epub:
Yes
Abstract:
Epiboly spreads and thins the blastoderm over the yolk cell during zebrafish gastrulation. Despite of its fundamental function...
Link:
https://academic.oup.com/abbs/advance-article-abstract/doi/10.1093/abbs/gmy136/5153309
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang W, Zhang Y, Li S, Wu Z, Yan Y, Li Y. Prmt7 regulates epiboly and gastrulation cell movements by facilitating syntenin. Acta Biochim Biophys Sin (Shanghai). 2018 Nov 1. doi: 10.1093/abbs/gmy136. [Epub ahead of print].

Naa15 knockdown enhances c2c12 myoblast fusion and induces defects in zebrafish myotome morphogenesis

Authors:
Monestier O, Landemaine A, Bugeon J, Rescan PY, Gabillard JC
Citation:
Comp Biochem Physiol B Biochem Mol Biol. 2019 Feb;228:61-67. doi: 10.1016/j.cbpb.2018.11.005. Epub 2018 Nov 29. PMID: 30502388
Epub:
Not Epub
Abstract:
The understanding of muscle tissue formation and regeneration is essential for the development of therapeutic approaches to...
Link:
https://linkinghub.elsevier.com/retrieve/pii/S1096-4959(18)30152-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Monestier O, Landemaine A, Bugeon J, Rescan PY, Gabillard JC. Naa15 knockdown enhances c2c12 myoblast fusion and induces defects in zebrafish myotome morphogenesis. Comp Biochem Physiol B Biochem Mol Biol. 2019 Feb;228:61-67. doi: 10.1016/j.cbpb.2018.11.005. Epub 2018 Nov 29. PMID: 30502388.

Draxin alters laminin organization during basement membrane remodeling to control cranial neural crest EMT

Authors:
Hutchins EJ, Bronner ME
Citation:
Dev Biol. 2019 Feb 15;446(2):151-158. doi: 10.1016/j.ydbio.2018.12.021. Epub 2018 Dec 21. PMID: 30579765; PMCID: PMC6368465
Epub:
Not Epub
Abstract:
Premigratory neural crest cells arise within the dorsal neural tube and subsequently undergo an epithelial-to-mesenchymal...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6368465/
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Hutchins EJ, Bronner ME. Draxin alters laminin organization during basement membrane remodeling to control cranial neural crest EMT. Dev Biol. 2019 Feb 15;446(2):151-158. doi: 10.1016/j.ydbio.2018.12.021. Epub 2018 Dec 21. PMID: 30579765; PMCID: PMC6368465.

EvpP inhibits neutrophils recruitment via Jnk-caspy inflammasome signaling in vivo

Authors:
Tan J, Yang D, Wang Z, Zheng X, Zhang Y, Liu Q
Citation:
Fish Shellfish Immunol. 2019 Sep;92:851-860. doi: 10.1016/j.fsi.2019.05.051. Epub 2019 May 23. PMID: 31129187
Epub:
Not Epub
Abstract:
Innate immunity is regulated by phagocytic cells and is critical for host control of bacterial infection. In many bacteria, the...
Link:
https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(19)30618-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tan J, Yang D, Wang Z, Zheng X, Zhang Y, Liu Q. EvpP inhibits neutrophils recruitment via Jnk-caspy inflammasome signaling in vivo. Fish Shellfish Immunol. 2019 Sep;92:851-860. doi: 10.1016/j.fsi.2019.05.051. Epub 2019 May 23. PMID: 31129187.

The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development

Authors:
Espiritu EB, Crunk AE, Bais A, Hochbaum D, Cervino AS, Phua YL, Butterworth MB, Goto T, Ho J, Hukriede NA, Cirio MC
Citation:
Sci Rep. 2018 Oct 30;8(1):16029. doi:10.1038/s41598-018-34038-x
Epub:
Not Epub
Abstract:
The molecular events driving specification of the kidney have been well characterized. However, how the initial kidney field...
Link:
https://www.nature.com/articles/s41598-018-34038-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Espiritu EB, Crunk AE, Bais A, Hochbaum D, Cervino AS, Phua YL, Butterworth MB, Goto T, Ho J, Hukriede NA, Cirio MC. The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development. Sci Rep. 2018 Oct 30;8(1):16029. doi:10.1038/s41598-018-34038-x.

Simplet-dependent regulation of β-catenin signaling influences skeletal patterning downstream of Cx43

Authors:
Bhattacharya S, Gargiulo D, Iovine MK
Citation:
Development. 2018;[Epub ahead of print] doi: 10.1242/dev.166975
Epub:
Yes
Abstract:
The correct positioning of joints in the vertebrate skeleton is not well understood. Mutations in connexin43 (cx43) cause the...
Link:
http://dev.biologists.org/content/early/2018/10/29/dev.166975
Organism or Cell Type:
zebrafish
Citation Extract:
Bhattacharya S, Gargiulo D, Iovine MK. Simplet-dependent regulation of β-catenin signaling influences skeletal patterning downstream of Cx43. Development. 2018;[Epub ahead of print] doi: 10.1242/dev.166975.

WDR5 regulates left-right patterning via chromatin dependent and independent functions

Authors:
Kulkarni SS, Khokha MF
Citation:
Development. 2018;[Epub ahead of print] doi: 10.1242/dev.159889
Epub:
Yes
Abstract:
Congenital heart disease (CHD) is a major cause of infant mortality and morbidity, yet the genetic causes and mechanisms remain...
Link:
http://dev.biologists.org/content/early/2018/10/29/dev.159889
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kulkarni SS, Khokha MF. WDR5 regulates left-right patterning via chromatin dependent and independent functions. Development. 2018;[Epub ahead of print] doi: 10.1242/dev.159889.

Antisense oligonucleotides modulate dopa decarboxylase function in aromatic l-amino acid decarboxylase deficiency

Authors:
Tsai CR, Lee HF, Chi CS, Yang MT, Hsu CC
Citation:
Hum Mutat. 2018 Sep 27. doi: 10.1002/humu.23659. [Epub ahead of print]
Epub:
Yes
Abstract:
Aromatic l-amino acid decarboxylase deficiency (AADCD), attributed to mutations in the dopa decarboxylase (DDC) gene, is a rare...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23659
Organism or Cell Type:
cell culture: primary human lymphoblastoid cells
Citation Extract:
Tsai CR, Lee HF, Chi CS, Yang MT, Hsu CC. Antisense oligonucleotides modulate dopa decarboxylase function in aromatic l-amino acid decarboxylase deficiency. Hum Mutat. 2018 Sep 27. doi: 10.1002/humu.23659. [Epub ahead of print].

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity

Authors:
Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH
Citation:
J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.
Epub:
Not Epub
Abstract:
Erythropoietin (EPO) signaling is critical to many processes essential to terminal erythropoiesis. Despite the centrality of...
Link:
http://www.jbc.org/content/293/51/19797.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26..

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