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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12475 scientific papers returned from the database with the search filters currently being used below.

Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis

Authors:
Haillot E, Lebedeva T, Steger J, Genikhovich G, Montenegro JD, Cole AG, Technau U
Citation:
Nat Commun. 2025 Aug 27;16(1):7979. doi: 10.1038/s41467-025-63287-4. PMID: 40858588; PMCID: PMC12381260
Epub:
Not Epub
Abstract:
A recent study suggested that morphologically diploblastic sea anemones (Cnidaria) have three segregated germ layer identities...
Link:
https://www.nature.com/articles/s41467-025-63287-4
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anenome)
Citation Extract:
Haillot E, Lebedeva T, Steger J, Genikhovich G, Montenegro JD, Cole AG, Technau U. Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis. Nat Commun. 2025 Aug 27;16(1):7979. doi: 10.1038/s41467-025-63287-4. PMID: 40858588; PMCID: PMC12381260.

Microtubule acetylation by ⍺TAT1 is essential for touch sensation in zebrafish but dispensable for embryonic development

Authors:
Bertrand SG, Grimes DT
Citation:
bioRxiv [Preprint]. 2025 Aug 11:2025.08.07.669193. doi: 10.1101/2025.08.07.669193. PMID: 40832302; PMCID: PMC12363851
Epub:
Not Epub
Abstract:
Acetylation of ⍺-tubulin at lysine 40 (⍺-tubK40Ac) is a conserved post-translational modification that occurs on the...
Link:
https://www.biorxiv.org/content/10.1101/2025.08.07.669193v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bertrand SG, Grimes DT. Microtubule acetylation by ⍺TAT1 is essential for touch sensation in zebrafish but dispensable for embryonic development. bioRxiv [Preprint]. 2025 Aug 11:2025.08.07.669193. doi: 10.1101/2025.08.07.669193. PMID: 40832302; PMCID: PMC12363851.

Supracellular contractility in Xenopus embryo epithelia regulated by extracellular ATP and the purinergic receptor P2Y2

Authors:
Joshi SD, Jackson TR, Zhang L, Stuckenholz C, Davidson LA
Citation:
J Cell Sci. 2025 Aug 26:jcs.263877. doi: 10.1242/jcs.263877. Epub ahead of print. PMID: 40856002
Epub:
Not Epub
Abstract:
Extracellular signals regulate epithelial homeostasis, cell fate and pattern cell behaviors during embryogenesis, wound healing...
Link:
https://journals.biologists.com/jcs/article/doi/10.1242/jcs.263877/368966/Supracellular-contractility-in-Xenopus-embryo
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Joshi SD, Jackson TR, Zhang L, Stuckenholz C, Davidson LA. Supracellular contractility in Xenopus embryo epithelia regulated by extracellular ATP and the purinergic receptor P2Y2. J Cell Sci. 2025 Aug 26:jcs.263877. doi: 10.1242/jcs.263877. Epub ahead of print. PMID: 40856002.

Phospholipase D2 Regulates Microtubule Acetylation by Modulating Gsk3β-Tau Signaling in Mouse Oocytes During Meiotic Maturation

Authors:
Zhang N, Tian Y, Xu X, Wang B, Lou S, Kang J, Li J, Liang Y, Weng J, Ma W
Citation:
Mol Reprod Dev. 2025 Aug;92(8):e70051. doi: 10.1002/mrd.70051. PMID: 40838360
Epub:
Not Epub
Abstract:
Phospholipase D2 (PLD2) modulates cytoskeletal dynamics and membrane trafficking processes by converting phosphatidylcholine (...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mrd.70051
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocytes
Citation Extract:
Zhang N, Tian Y, Xu X, Wang B, Lou S, Kang J, Li J, Liang Y, Weng J, Ma W. Phospholipase D2 Regulates Microtubule Acetylation by Modulating Gsk3β-Tau Signaling in Mouse Oocytes During Meiotic Maturation. Mol Reprod Dev. 2025 Aug;92(8):e70051. doi: 10.1002/mrd.70051. PMID: 40838360.

Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy

Authors:
Li Y, Singh N, Dong C, Sharma S, Zhou Z, Du J, Haouili M, Jiao Y, Hopewell E, Liu Y, Opyrchal M, Zhang X, Zhou B, Lu X
Citation:
Sci Immunol. 2025 Aug 22;10(110):eadr9933. doi: 10.1126/sciimmunol.adr9933. Epub 2025 Aug 22. PMID: 40845126.
Epub:
Not Epub
Abstract:
Regulatory T cells (Treg cells) represent a primary barrier to the development of effective antitumor immunity. Here, we report...
Link:
https://www.science.org/doi/10.1126/sciimmunol.adr9933
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
PMO-treated Treg splenic cells isolated from wild type or Foxp3dE2 mice co-cultured with human breast cancer and human colorectal cancer patient-derived tumor organoids
Citation Extract:
Li Y, Singh N, Dong C, Sharma S, Zhou Z, Du J, Haouili M, Jiao Y, Hopewell E, Liu Y, Opyrchal M, Zhang X, Zhou B, Lu X. Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy. Sci Immunol. 2025 Aug 22;10(110):eadr9933. doi: 10.1126/sciimmunol.adr9933. Epub 2025 Aug 22. PMID: 40845126..

Heparanase 2 Modulates Vascular Permeability via Heparan Sulfate-Dependent Growth Factor Signaling

Authors:
Becker Y, Tkachuk S, Jörns A, Shushakova N, Rong S, Alwakaa A, Hegermann J, Schenk H, Kiyan Y, Haller H
Citation:
Arterioscler Thromb Vasc Biol. 2025 Aug 21. doi: 10.1161/ATVBAHA.125.323060. Epub ahead of print. PMID: 40836917
Epub:
Not Epub
Abstract:
Background: Vessel-lining endothelial cells (ECs) rely on heparan sulfate (HS) proteoglycans to regulate vascular permeability...
Link:
https://www.ahajournals.org/doi/10.1161/ATVBAHA.125.323060
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Becker Y, Tkachuk S, Jörns A, Shushakova N, Rong S, Alwakaa A, Hegermann J, Schenk H, Kiyan Y, Haller H. Heparanase 2 Modulates Vascular Permeability via Heparan Sulfate-Dependent Growth Factor Signaling. Arterioscler Thromb Vasc Biol. 2025 Aug 21. doi: 10.1161/ATVBAHA.125.323060. Epub ahead of print. PMID: 40836917.

PTBP3 Associated With 9q32 Locus Is a Candidate Gene for Nager Syndrome

Authors:
Gonzalez JA, Devotta A, Hong CS, Griffin C, Saint-Jeannet JP
Citation:
Birth Defects Res. 2025 Aug;117(8):e2518. doi: 10.1002/bdr2.2518. PMID: 40820387
Epub:
Not Epub
Abstract:
Background: Mandibulofacial dysostosis (MFD) is a congenital disorder characterized by defects in facial bones of neural crest...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2518
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Gonzalez JA, Devotta A, Hong CS, Griffin C, Saint-Jeannet JP. PTBP3 Associated With 9q32 Locus Is a Candidate Gene for Nager Syndrome. Birth Defects Res. 2025 Aug;117(8):e2518. doi: 10.1002/bdr2.2518. PMID: 40820387.

Molecular Properties and Intramolecular interactions of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides

Authors:
Kliuchnikov E, Maksudov F, Pierson D, Marx KA, Chanda A, Barsegov V
Citation:
Molecular Therapy - Nucleic Acids (2025)
Epub:
Not Epub
Abstract:
We combined Circular Dichroism (CD) and viscosity measurements with MD simulations and classification and regression approaches...
Link:
https://www.sciencedirect.com/science/article/pii/S2162253125002392
Delivery Method:
peptide-linked
Citation Extract:
Kliuchnikov E, Maksudov F, Pierson D, Marx KA, Chanda A, Barsegov V. Molecular Properties and Intramolecular interactions of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Molecular Therapy - Nucleic Acids (2025).

Reelin/Disabled-1 Signalling Contributes to Functional Recovery on Zebrafish After Spinal Cord Injury

Authors:
Li R, Sahu S
Citation:
Int J Dev Neurosci. 2025 Aug;85(5):e70045. doi: 10.1002/jdn.70045. PMID: 40798876
Epub:
Not Epub
Abstract:
Reelin, an extracellular matrix glycoprotein, plays important roles in neural development. Mutation-induced loss of its...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/jdn.70045
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li R, Sahu S. Reelin/Disabled-1 Signalling Contributes to Functional Recovery on Zebrafish After Spinal Cord Injury. Int J Dev Neurosci. 2025 Aug;85(5):e70045. doi: 10.1002/jdn.70045. PMID: 40798876.

Guanidinium-linked morpholino-siRNA chimera: synthesis, biophysical properties and in vitro activity

Authors:
Gupta S, Ghosh A, Pratihar S, Mukherjee M, Kundu J, Sinha S
Citation:
Chem Commun (Camb). 2025 Aug 22. doi: 10.1039/d5cc03543k. Epub ahead of print. PMID: 40842421
Epub:
Not Epub
Abstract:
This study introduces guanidinium morpholino RNA (GMO-RNA), an RNA analogue with enhanced cell permeability, nuclease...
Link:
https://pubs.rsc.org/en/content/articlelanding/2025/cc/d5cc03543k
Organism or Cell Type:
cell culture: PC-3, DU 145, MDA-MB-231, MCF7, HepG2
Citation Extract:
Gupta S, Ghosh A, Pratihar S, Mukherjee M, Kundu J, Sinha S. Guanidinium-linked morpholino-siRNA chimera: synthesis, biophysical properties and in vitro activity. Chem Commun (Camb). 2025 Aug 22. doi: 10.1039/d5cc03543k. Epub ahead of print. PMID: 40842421.

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