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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish -- implications for neurodevelopmental disorders

Authors:
Lüffe TM, D’Orazio A, Bauer M, Gioga Z, Schoeffler V, Lesch K-P, Romanos Ml, Drepper C, Lillesaar C
Citation:
Transl Psychiatry. 2021;11:529. doi:10.1038/s41398-021-01651-w
Epub:
Not Epub
Abstract:
Recent advances in the genetics of neurodevelopmental disorders (NDDs) have identified the transcription factor FOXP2 as one of...
Link:
https://www.nature.com/articles/s41398-021-01651-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lüffe TM, D’Orazio A, Bauer M, Gioga Z, Schoeffler V, Lesch K-P, Romanos Ml, Drepper C, Lillesaar C. Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish -- implications for neurodevelopmental disorders. Transl Psychiatry. 2021;11:529. doi:10.1038/s41398-021-01651-w.

Antisense oligonucleotides: absorption, distribution, metabolism, and excretion

Authors:
Shadid M, Badawi M, Abulrob A
Citation:
Expert Opin Drug Metab Toxicol. 2021 Oct 13. doi: 10.1080/17425255.2021.1992382. Online ahead of print
Epub:
Yes
Abstract:
Introduction: Antisense oligonucleotides (ASOs) have emerged as a promising novel drug modality that aims to address unmet...
Link:
https://www.tandfonline.com/doi/full/10.1080/17425255.2021.1992382
Citation Extract:
Shadid M, Badawi M, Abulrob A. Antisense oligonucleotides: absorption, distribution, metabolism, and excretion. Expert Opin Drug Metab Toxicol. 2021 Oct 13. doi: 10.1080/17425255.2021.1992382. Online ahead of print.

CNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production

Authors:
Tan KS, Wang D, Lu Z, Zhang Y, Li S, Lin Y, Tan W
Citation:
Int J Mol Sci. 2021 Oct 6;22(19):10806. doi: 10.3390/ijms221910806
Epub:
Not Epub
Abstract:
Heart failure is the end-stage of all cardiovascular diseases with a ~25% 5-year survival rate, and insufficient mitochondrial...
Link:
https://www.mdpi.com/1422-0067/22/19/10806
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tan KS, Wang D, Lu Z, Zhang Y, Li S, Lin Y, Tan W. CNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production. Int J Mol Sci. 2021 Oct 6;22(19):10806. doi: 10.3390/ijms221910806.

Stretch-induced endogenous electric fields drive neural crest directed collective cell migration in vivo

Authors:
Ferreira F, Moreira S, Barriga EH
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.11.463916
Epub:
Not Epub
Abstract:
Directed collective cell migration (dCCM) is essential for morphogenesis. Cell clusters migrate in inherently complex in vivo...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.11.463916v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ferreira F, Moreira S, Barriga EH. Stretch-induced endogenous electric fields drive neural crest directed collective cell migration in vivo. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.11.463916.

Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals

Authors:
Kruyer A, Dixon D, Angelis A, Amato D, Kalivas PW
Citation:
Mol Psychiatry. 2021;[Epub]. doi:10.1038/s41380-021-01333-5
Epub:
Not Epub
Abstract:
GABAergic projections from the nucleus accumbens core to the dorsolateral ventral pallidum are necessary for drug-conditioned...
Link:
https://www.nature.com/articles/s41380-021-01333-5
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Rat
Citation Extract:
Kruyer A, Dixon D, Angelis A, Amato D, Kalivas PW. Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals. Mol Psychiatry. 2021;[Epub]. doi:10.1038/s41380-021-01333-5.

RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues

Authors:
Zhang N, Tan C, Cai P, Zhang P, Zhao Y, Jiang Y
Citation:
Bioorg Med Chem. 2009 Mar 15;17(6):2441-6. doi: 10.1016/j.bmc.2009.02.001. Epub 2009 Feb 8
Epub:
Not Epub
Abstract:
siRNAs modified with morpholino nucleoside analogues were synthesized and their biological properties were examined in details...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0968089609001345
Organism or Cell Type:
cell culture
Citation Extract:
Zhang N, Tan C, Cai P, Zhang P, Zhao Y, Jiang Y. RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues. Bioorg Med Chem. 2009 Mar 15;17(6):2441-6. doi: 10.1016/j.bmc.2009.02.001. Epub 2009 Feb 8.

Regulation of Nav1.6-mediated sodium currents underlie the homeostatic control of neuronal intrinsic excitability in the optic tectum of the developing Xenopus laevis tadpole

Authors:
Thompson AC, Aizenman CD
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.07.463558
Epub:
Not Epub
Abstract:
For individual neurons to function appropriately within a network that is undergoing synaptic reorganization and refinement due...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.07.463558v1
Delivery Method:
injection then electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Thompson AC, Aizenman CD. Regulation of Nav1.6-mediated sodium currents underlie the homeostatic control of neuronal intrinsic excitability in the optic tectum of the developing Xenopus laevis tadpole. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.07.463558 .

Trypsin induces an aversive response in zebrafish by PAR2 activation in keratinocytes

Authors:
Alsrhani A, Raman R, Jagadeeswaran P
Citation:
PLoS One. 2021 Oct 8;16(10):e0257774. doi: 10.1371/journal.pone.0257774. eCollection 2021
Epub:
Not Epub
Abstract:
Previously we have shown that trypsin, a protein typically involved in digestion, is released from gills of both fresh and...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257774
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Alsrhani A, Raman R, Jagadeeswaran P. Trypsin induces an aversive response in zebrafish by PAR2 activation in keratinocytes. PLoS One. 2021 Oct 8;16(10):e0257774. doi: 10.1371/journal.pone.0257774. eCollection 2021.

SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype

Authors:
Motta M, Fasano G, Gredy S, Brinkmann J, Bonnard AA, Simsek-Kiper PO, Gulec EY, Essaddam L, Utine GE, Guarnetti Prandi I, Venditti M, Pantaleoni F, Radio FC, Ciolfi A, Petrini S, Consoli F, Vignal C, Hepbasli D, Ullrich M, de Boer E, Vissers LELM, Gritli S, Rossi C, De Luca A, Ben Becher S, Gelb BD, Dallapiccola B, Lauri A, Chillemi G, Schuh K, Cavé H, Zenker M, Tartaglia M
Citation:
Am J Hum Genet. 2021 Oct 1:S0002-9297(21)00343-8. doi: 10.1016/j.ajhg.2021.09.007. Online ahead of print
Epub:
Not Epub
Abstract:
Upregulated signal flow through RAS and the mitogen-associated protein kinase (MAPK) cascade is the unifying mechanistic theme...
Link:
https://www.cell.com/ajhg/fulltext/S0002-9297(21)00343-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Motta M, Fasano G, Gredy S, Brinkmann J, Bonnard AA, Simsek-Kiper PO, Gulec EY, Essaddam L, Utine GE, Guarnetti Prandi I, Venditti M, Pantaleoni F, Radio FC, Ciolfi A, Petrini S, Consoli F, Vignal C, Hepbasli D, Ullrich M, de Boer E, Vissers LELM, Gritli S, Rossi C, De Luca A, Ben Becher S, Gelb BD, Dallapiccola B, Lauri A, Chillemi G, Schuh K, Cavé H, Zenker M, Tartaglia M. SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype. Am J Hum Genet. 2021 Oct 1:S0002-9297(21)00343-8. doi: 10.1016/j.ajhg.2021.09.007. Online ahead of print.

Crucial role of dead end gene for primordial germ cell survival in rice field eel (Monopterus albus)

Authors:
Hu Q, Xiao Q, Tian H, Li D, Li Z
Citation:
Theriogenology. 2021 Oct 3;176:188-193. doi: 10.1016/j.theriogenology.2021.09.036. Online ahead of print
Epub:
Not Epub
Abstract:
The dead end gene has been identified as a essential factor for Primordial germ cells (PGCs) migration and survival in many...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0093691X21003678
Delivery Method:
microinjection
Organism or Cell Type:
Monopterus albus (rice field eel)
Citation Extract:
Hu Q, Xiao Q, Tian H, Li D, Li Z. Crucial role of dead end gene for primordial germ cell survival in rice field eel (Monopterus albus). Theriogenology. 2021 Oct 3;176:188-193. doi: 10.1016/j.theriogenology.2021.09.036. Online ahead of print.

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