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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
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Citation:
eLife. 2021;10:e59067 doi:10.7554/eLife.59067 Epub:
Not Epub Abstract:
Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDC, Gaulton KJ, Sander M. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. eLife. 2021;10:e59067 doi:10.7554/eLife.59067. |
l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain
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Citation:
Front Genet. 2021 Jan 21;11:612343. doi: 10.3389/fgene.2020.612343. eCollection 2020 Epub:
Not Epub Abstract:
Isomerization of l-aspartyl and l-asparaginyl residues to l-isoaspartyl residues is one type of protein damage that can occur... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Soliman R, Cordero-Maldonado ML, Martins TG, Moein M, Conrotte JF, Warmack RA, Skupin A, Crawford AD, Clarke SG, Linster CL. l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain. Front Genet. 2021 Jan 21;11:612343. doi: 10.3389/fgene.2020.612343. eCollection 2020. |
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine
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Citation:
Nat Commun. 2021 Feb 5;12(1):833. doi: 10.1038/s41467-021-21053-2 Epub:
Not Epub Abstract:
The structure of proline prevents it from adopting an optimal position for rapid protein synthesis. Poly-proline-tract (PPT)... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AGL, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S. Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine. Nat Commun. 2021 Feb 5;12(1):833. doi: 10.1038/s41467-021-21053-2. |
Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk
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Citation:
Development. 2021 Feb 5:dev.194993. doi: 10.1242/dev.194993. Online ahead of print Epub:
Not Epub Abstract:
Previous studies have shown that Vasohibin-1 (Vash1) is stimulated by VEGFs in endothelial cells and that its overexpression... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bastos de Oliveira M, Meier K, Jung S, Bartels-Klein E, Coxam B, Geudens I, Szymborska A, Skoczylas R, Fechner I, Koltowska K, Gerhardt H. Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. Development. 2021 Feb 5:dev.194993. doi: 10.1242/dev.194993. Online ahead of print. |
SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa
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Citation:
Front Med (Lausanne). 2021 Jan 21;7:588991. doi: 10.3389/fmed.2020.588991 Epub:
Not Epub Abstract:
The small nuclear ribonucleoprotein 200 kDa (SNRNP200) gene plays a key role in the maturation of pre-message RNA (pre-mRNA)... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang T, Bai J, Zhang X, Zheng X, Lu N, Liang Z, Lin L, Chen Y. SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa. Front Med (Lausanne). 2021 Jan 21;7:588991. doi: 10.3389/fmed.2020.588991. |
Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy
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Citation:
J Cell Sci. 2021;[Epub ahead of print] doi:10.1242/jcs.256255 Epub:
Yes Abstract:
Mitophagy, the selective recycling of mitochondria through autophagy, is a crucial metabolic process induced by cellular stress... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wrighton PJ, Shwartz A, Heo J-M, Quenzer ED, LaBella KA, Harper JW, Goessling W. Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy. J Cell Sci. 2021;[Epub ahead of print] doi:10.1242/jcs.256255. |
A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation
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Citation:
Blood Adv. 2021;5(3):796-811. doi:10.1182/bloodadvances.2020003096 Epub:
Not Epub Abstract:
Granulin is a pleiotropic protein involved in inflammation, wound healing, neurodegenerative disease, and tumorigenesis. These... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Campbell CA, Fursova O, Cheng X, Snella E, McCune A, Li L, Solchenberger B, Schmid B, Sahoo D, Morton M, Traver D, Palazon RE. A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood Adv. 2021;5(3):796-811. doi:10.1182/bloodadvances.2020003096. |
Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish
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Citation:
J Mol Cell Cardiol. 2021;[Epub ahead of print] doi:10.1016/j.yjmcc.2021.01.006 Epub:
Yes Abstract:
Genome-wide association studies identified Spen as a putative modifier of cardiac function, however, the precise function of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rattka M, Westphal S, Gahr BM, Just S, Rottbauer W. Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish. J Mol Cell Cardiol. 2021;[Epub ahead of print] doi:10.1016/j.yjmcc.2021.01.006. |
Dynein regulates Kv7.4 channel trafficking from the cell membrane
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Citation:
Gen Physiol (2021) 153 (3): e202012760. doi:10.1085/jgp.202012760 Epub:
Yes Abstract:
The dynein motor protein transports proteins away from the cell membrane along the microtubule network. Recently, we found the... Organism or Cell Type:
cell culture: HEK293B Citation Extract: van der Horst J, Rognant S, Abbott GW, Ozhathil LC, Hägglund P, Barrese V, Chuang CY, Jespersen T, Davies MJ, Greenwood IA, Gourdon P, Aalkjær C, Jepps TA. Dynein regulates Kv7.4 channel trafficking from the cell membrane. Gen Physiol (2021) 153 (3): e202012760. doi:10.1085/jgp.202012760. |
GAA deficiency promotes angiogenesis through upregulation of Rac1 induced by autophagy disorder
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Citation:
Biochim Biophys Acta Mol Cell Res. 2021 Jan 26;1868(5):118969. doi: 10.1016/j.bbamcr.2021.118969. Online ahead of print Epub:
Not Epub Abstract:
Angiogenesis, the formation of new blood vessels from pre-existing ones, is vital for vertebrate development and adult... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li Z, Li B, Wang J, Lu Y, Chen AFY, Sun K, Yu Y, Chen S. GAA deficiency promotes angiogenesis through upregulation of Rac1 induced by autophagy disorder. Biochim Biophys Acta Mol Cell Res. 2021 Jan 26;1868(5):118969. doi: 10.1016/j.bbamcr.2021.118969. Online ahead of print. |