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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

A dystrophic Duchenne mouse model for testing human antisense oligonucleotides

Authors:
Veltrop M, van Vliet L, Hulsker M, Claassens J, Brouwers C, Breukel C, van der Kaa J, Linssen MM, den Dunnen JT, Verbeek S, Aartsma-Rus A, van Putten M
Citation:
PLoS ONE. 2018;13(2):e0193289. doi:10.1371/journal.pone.0193289
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease generally caused by reading frame disrupting mutations in...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193289
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
del52hDMD/mdx mouse
Citation Extract:
Veltrop M, van Vliet L, Hulsker M, Claassens J, Brouwers C, Breukel C, van der Kaa J, Linssen MM, den Dunnen JT, Verbeek S, Aartsma-Rus A, van Putten M. A dystrophic Duchenne mouse model for testing human antisense oligonucleotides. PLoS ONE. 2018;13(2):e0193289. doi:10.1371/journal.pone.0193289.

Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery in vitro and in mdx Mice

Authors:
Wang M, Wu B, Shah SN, Lu P, Lu Q
Citation:
Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.004
Epub:
Yes
Abstract:
Antisense oligonucleotide (AON) therapy for Duchenne muscular dystrophy has drawn great attention in preclinical and clinical...
Link:
https://www.sciencedirect.com/science/article/pii/S2162253118300180
Delivery Method:
Endo-Porter or Saponin in culture, injection in mice
Organism or Cell Type:
cell culture: C2C12E50, C2C12E23; mice, mdx
Citation Extract:
Wang M, Wu B, Shah SN, Lu P, Lu Q. Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery in vitro and in mdx Mice. Molec Ther Nucl Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.02.004.

Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates

Authors:
Kirillova A, Genikhovich G, Pukhlyakova E, Demilly A, Kraus Y, Technau U
Citation:
Proc Natl Acad Sci U S A. 2018 Feb 9. pii: 201711516. doi: 10.1073/pnas.1711516115. [Epub ahead of print]
Epub:
Yes
Abstract:
Robust morphogenetic events are pivotal for animal embryogenesis. However, comparison of the modes of development of different...
Link:
http://www.pnas.org/content/115/8/1813
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Kirillova A, Genikhovich G, Pukhlyakova E, Demilly A, Kraus Y, Technau U. Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates. Proc Natl Acad Sci U S A. 2018 Feb 9. pii: 201711516. doi: 10.1073/pnas.1711516115. [Epub ahead of print].

Antisense inhibitors retain activity in pulmonary models of Burkholderia infection

Authors:
Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller B, Greenberg D
Citation:
ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print]
Epub:
Yes
Abstract:
The Burkholderia cepacia complex is a group of gram-negative bacteria that are opportunistic pathogens in immunocompromised...
Link:
https://pubs.acs.org/doi/10.1021/acsinfecdis.7b00235
Delivery Method:
peptide-linked
Organism or Cell Type:
Burkholderia cepacia, Pseudomonas
Citation Extract:
Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller B, Greenberg D. Antisense inhibitors retain activity in pulmonary models of Burkholderia infection. ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print].

Amplification-free detection of DNA in a paper-based microfluidic device using electroosmotically balanced isotachophoresis

Authors:
Rosenfeld T, Bercovici M
Citation:
Lab Chip. 2018 Feb 20. doi: 10.1039/c7lc01250k. [Epub ahead of print]
Epub:
Not Epub
Abstract:
We present a novel microfluidic paper-based analytical device (μPAD) which utilizes the native high electroosmotic flow (EOF)...
Link:
http://pubs.rsc.org/en/content/articlelanding/2018/lc/c7lc01250k#!divAbstract
Citation Extract:
Rosenfeld T, Bercovici M. Amplification-free detection of DNA in a paper-based microfluidic device using electroosmotically balanced isotachophoresis. Lab Chip. 2018 Feb 20. doi: 10.1039/c7lc01250k. [Epub ahead of print].

Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype

Authors:
Yao L, Chen J, Wu X, Jia S, Meng A
Citation:
Hum Molec Genet. 20-18;26(21):4168-80. doi:10.1093/hmg/ddx305
Epub:
Not Epub
Abstract:
Cell Division Cycle 6 (Cdc6) is a component of pre-replicative complex (preRC) forming on DNA replication origins in eukaryotes...
Link:
https://academic.oup.com/hmg/article/26/21/4168/4060582
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yao L, Chen J, Wu X, Jia S, Meng A. Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Hum Molec Genet. 20-18;26(21):4168-80. doi:10.1093/hmg/ddx305.

The Beta-Adrenergic Agonist Salbutamol Modulates Neuromuscular Junction Formation in Zebrafish Models of Human Myasthenic Syndromes

Authors:
McMacken G, Cox D, Roos A, Müller J, Whittaker R, Lochmüller H
Citation:
Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy062
Epub:
Yes
Abstract:
Inherited defects of the neuromuscular junction (NMJ) comprise an increasingly diverse range of disorders, termed congenital...
Link:
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddy062/4866403
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
McMacken G, Cox D, Roos A, Müller J, Whittaker R, Lochmüller H. The Beta-Adrenergic Agonist Salbutamol Modulates Neuromuscular Junction Formation in Zebrafish Models of Human Myasthenic Syndromes. Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy062.

MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion

Authors:
O’Connor E, Phan V, Cordts I, Cairns G, Hettwer S, Cox D, Lochmüller H, Roos A
Citation:
Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy054
Epub:
Yes
Abstract:
Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterised by compromised function of the...
Link:
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddy054/4866401
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
O’Connor E, Phan V, Cordts I, Cairns G, Hettwer S, Cox D, Lochmüller H, Roos A. MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion. Hum Molec Genet. 2018;[Epub ahead of print] doi:10.1093/hmg/ddy054.

Dicer inactivation stimulates limb regeneration ability in Xenopus laevis

Authors:
Zhang M, Yang L, Yuan F, Chen Y, Lin G
Citation:
Wound Repair Regen. 2018 Feb 17. doi: 10.1111/wrr.12619. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The ontogenetic decline of regeneration capacity in the anuran amphibian Xenopus makes it an excellent model for regeneration...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/wrr.12619/abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Zhang M, Yang L, Yuan F, Chen Y, Lin G. Dicer inactivation stimulates limb regeneration ability in Xenopus laevis. Wound Repair Regen. 2018 Feb 17. doi: 10.1111/wrr.12619. [Epub ahead of print].

Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss

Authors:
Gao X, Yuan YY, Lin QF, Xu JC, Wang WQ, Qiao YH, Kang DY, Bai D, Xin F, Huang SS, Qiu SW, Guan LP, Su Y, Wang GJ, Han MY, Jiang Y, Liu HK, Dai P
Citation:
J Med Genet. 2018 Feb 16. pii: jmedgenet-2017-104954. doi: 10.1136/jmedgenet-2017-104954. [Epub ahead of print]
Epub:
Yes
Abstract:
Background Hereditary sensorineural hearing loss is a genetically heterogeneous disorder.Objectives This study was designed to...
Link:
http://jmg.bmj.com/content/early/2018/02/16/jmedgenet-2017-104954
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gao X, Yuan YY, Lin QF, Xu JC, Wang WQ, Qiao YH, Kang DY, Bai D, Xin F, Huang SS, Qiu SW, Guan LP, Su Y, Wang GJ, Han MY, Jiang Y, Liu HK, Dai P. Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss. J Med Genet. 2018 Feb 16. pii: jmedgenet-2017-104954. doi: 10.1136/jmedgenet-2017-104954. [Epub ahead of print].

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