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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12511 scientific papers returned from the database with the search filters currently being used below.

Mucociliary Wnt signaling promotes cilia biogenesis and beating

Authors:
Seidl C, Da Silva F, Zhang K, Wohlgemuth K, Omran H, Niehrs C
Citation:
Nat Commun. 2023 Mar 6;14(1):1259. doi: 10.1038/s41467-023-36743-2
Epub:
Not Epub
Abstract:
It is widely thought that Wnt/Lrp6 signaling proceeds through the cytoplasm and that motile cilia are signaling-inert...
Link:
https://www.nature.com/articles/s41467-023-36743-2
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Seidl C, Da Silva F, Zhang K, Wohlgemuth K, Omran H, Niehrs C. Mucociliary Wnt signaling promotes cilia biogenesis and beating. Nat Commun. 2023 Mar 6;14(1):1259. doi: 10.1038/s41467-023-36743-2.

Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis

Authors:
Murayama E, Vivier C, Schmidt A, Herbomel P
Citation:
Nat Commun. 2023 Mar 1;14(1):1171. doi: 10.1038/s41467-023-36612-y
Epub:
Not Epub
Abstract:
Mesenchymal stromal cells are essential components of hematopoietic stem and progenitor cell (HSPC) niches, regulating HSPC...
Link:
https://www.nature.com/articles/s41467-023-36612-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Murayama E, Vivier C, Schmidt A, Herbomel P. Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nat Commun. 2023 Mar 1;14(1):1171. doi: 10.1038/s41467-023-36612-y.

Migration and establishment of progenitor pool of melanocytes is governed by SEMA3E-PLXND1 signaling

Authors:
Subramaniam Y, Sharma B, Aggarwal A, Raja DA, Gupta I, Ghazi M, Sivasubbu S, Natarajan VT
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.02.28.530560
Epub:
Not Epub
Abstract:
Vertebrate pigmentation is an outcome of an interplay of several signaling pathways that result in immense diversity of pigment...
Link:
https://www.biorxiv.org/content/10.1101/2023.02.28.530560v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Subramaniam Y, Sharma B, Aggarwal A, Raja DA, Gupta I, Ghazi M, Sivasubbu S, Natarajan VT. Migration and establishment of progenitor pool of melanocytes is governed by SEMA3E-PLXND1 signaling. bioRxiv. 2023;[preprint] doi:10.1101/2023.02.28.530560 .

Temporal single-cell transcriptomic analysis of the sox1a:eGFP transgenic line identified the lateral floor plate progenitor cells as the origin of intraspinal serotonergic neurons

Authors:
Chen F, Köhler M, Cucun G, Takamiya M, Kizil C, Cosacak MI, Rastegar S
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.03.01.530240
Epub:
Not Epub
Abstract:
The Sox family of transcription factors plays a crucial role in the development of the vertebrate nervous system. In the...
Link:
https://www.biorxiv.org/content/10.1101/2023.03.01.530240v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen F, Köhler M, Cucun G, Takamiya M, Kizil C, Cosacak MI, Rastegar S. Temporal single-cell transcriptomic analysis of the sox1a:eGFP transgenic line identified the lateral floor plate progenitor cells as the origin of intraspinal serotonergic neurons. bioRxiv. 2023;[preprint] doi:10.1101/2023.03.01.530240.

Functional Differentiation of Cyclins and Cyclin-Dependent Kinases in Giardia lamblia

Authors:
Kim J, Park EA, Shin MY, Park SJ
Citation:
Microbiol Spectr. 2023 Mar 6:e0491922. doi: 10.1128/spectrum.04919-22. Online ahead of print
Epub:
Not Epub
Abstract:
Cyclin-dependent kinases (CDKs) are serine/threonine kinases that control the eukaryotic cell cycle. Limited information is...
Link:
https://journals.asm.org/doi/10.1128/spectrum.04919-22
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Kim J, Park EA, Shin MY, Park SJ. Functional Differentiation of Cyclins and Cyclin-Dependent Kinases in Giardia lamblia. Microbiol Spectr. 2023 Mar 6:e0491922. doi: 10.1128/spectrum.04919-22. Online ahead of print.

YULINK regulates vascular formation in zebrafish and HUVECs

Authors:
Lin HH, Kuo MW, Fan TC, Yu AL, Yu J
Citation:
Biol Res. 2023;56(7). doi:10.1186/s40659-023-00415-8
Epub:
Not Epub
Abstract:
Background: The distinct arterial and venous cell fates are dictated by a combination of various genetic factors which form...
Link:
https://biolres.biomedcentral.com/articles/10.1186/s40659-023-00415-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin HH, Kuo MW, Fan TC, Yu AL, Yu J. YULINK regulates vascular formation in zebrafish and HUVECs. Biol Res. 2023;56(7). doi:10.1186/s40659-023-00415-8.

In-Cell Penetration Selection-Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery

Authors:
Schissel CK, Farquhar CE, Loas A, Malmberg AB, Pentelute BL
Citation:
ACS Chem Biol. 2023 Mar 1. doi: 10.1021/acschembio.2c00920. Online ahead of print
Epub:
Yes
Abstract:
Peptide-mediated delivery of macromolecules in cells has significant potential therapeutic benefits, but no therapy employing...
Link:
https://pubs.acs.org/doi/10.1021/acschembio.2c00920
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Schissel CK, Farquhar CE, Loas A, Malmberg AB, Pentelute BL. In-Cell Penetration Selection-Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery. ACS Chem Biol. 2023 Mar 1. doi: 10.1021/acschembio.2c00920. Online ahead of print.

Mob4 is required for neurodevelopment in zebrafish

Authors:
Florindo C, Mimoso JM, Palma SL, Gonçalves C, Silvestre D, Campinho M, Tavares A
Citation:
microPublication Biology. 2023. 10.17912/micropub.biology.000762
Epub:
Not Epub
Abstract:
Mob4 is an essential evolutionary conserved protein shown to play roles in cell division and neural development. Mob4 is a core...
Link:
https://www.micropublication.org/journals/biology/micropub-biology-000762
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Florindo C, Mimoso JM, Palma SL, Gonçalves C, Silvestre D, Campinho M, Tavares A. Mob4 is required for neurodevelopment in zebrafish. microPublication Biology. 2023. 10.17912/micropub.biology.000762.

U1 AMO (antisense morpholino oligo) disrupts U1 snRNP structure to promote intronic premature cleavage and polyadenylation (PCPA)

Authors:
Feng Q, Lin Z, Deng Y, Ran Y, Xiang AP, Ye C, Yao C
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.02.24.529985
Epub:
Not Epub
Abstract:
Functional depletion of U1 snRNP with a 25 nt U1 AMO (antisense morpholino oligonucleotides) may lead to intronic premature...
Link:
https://www.biorxiv.org/content/10.1101/2023.02.24.529985v1
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Feng Q, Lin Z, Deng Y, Ran Y, Xiang AP, Ye C, Yao C. U1 AMO (antisense morpholino oligo) disrupts U1 snRNP structure to promote intronic premature cleavage and polyadenylation (PCPA). bioRxiv. 2023;[preprint] doi:10.1101/2023.02.24.529985.

Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish

Authors:
Khatri D, Putoux A, Cologne A, Kaltenbach S, Besson A, Bertiaux E, Guguin J, Fendler A, Dupont MA, Benoit-Pilven C, Qebibo L, Ahmed-Elie S, Audebert-Bellanger S, Blanc P, Rambaud T, Castelle M, Cornen G, Grotto S, Guët A, Guibaud L, Michot C, Odent S, Ruaud L, Sacaze E, Hamel V, Bordonné R, Leutenegger AL, Edery P, Burglen L, Attié-Bitach T, Mazoyer S, Delous M
Citation:
Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2102569120. doi: 10.1073/pnas.2102569120. Epub 2023 Feb 21
Epub:
Not Epub
Abstract:
In the human genome, about 750 genes contain one intron excised by the minor spliceosome. This spliceosome comprises its own...
Link:
https://www.pnas.org/doi/10.1073/pnas.2102569120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Khatri D, Putoux A, Cologne A, Kaltenbach S, Besson A, Bertiaux E, Guguin J, Fendler A, Dupont MA, Benoit-Pilven C, Qebibo L, Ahmed-Elie S, Audebert-Bellanger S, Blanc P, Rambaud T, Castelle M, Cornen G, Grotto S, Guët A, Guibaud L, Michot C, Odent S, Ruaud L, Sacaze E, Hamel V, Bordonné R, Leutenegger AL, Edery P, Burglen L, Attié-Bitach T, Mazoyer S, Delous M. Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish. Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2102569120. doi: 10.1073/pnas.2102569120. Epub 2023 Feb 21.

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