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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12165 scientific papers returned from the database with the search filters currently being used below.

miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations

Authors:
Hoelscher CS, Stich T, Diehm A, Lahm H, Dreßen M, Zhang Z, Neb I, Aherrahrou Z, Erdmann J, Schunkert H, Santamaria G, Cuda G, Gilsbach R, Hein L, Lange R, Hassel D, Krane M, Doppler AS
Citation:
Int J Molec Sci. 2020;21(3);1158. doi:10.3390/ijms21031158
Epub:
Not Epub
Abstract:
MicroRNAs (miRs) appear to be major, yet poorly understood players in regulatory networks guiding cardiogenesis. We sought to...
Link:
https://www.mdpi.com/1422-0067/21/3/1158
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hoelscher CS, Stich T, Diehm A, Lahm H, Dreßen M, Zhang Z, Neb I, Aherrahrou Z, Erdmann J, Schunkert H, Santamaria G, Cuda G, Gilsbach R, Hein L, Lange R, Hassel D, Krane M, Doppler AS. miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations. Int J Molec Sci. 2020;21(3);1158. doi:10.3390/ijms21031158.

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow

Authors:
Lundin V, Sugden WW, Theodore LN, Sousa PM, Han A, Chou S, Wrighton PJ, Cox AG, Ingber DE, Goessling W, Daley GQ, North TE
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.006
Epub:
Yes
Abstract:
Hematopoietic stem and progenitor cells (HSPCs), first specified from hemogenic endothelium (HE) in the ventral dorsal aorta (...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30007-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lundin V, Sugden WW, Theodore LN, Sousa PM, Han A, Chou S, Wrighton PJ, Cox AG, Ingber DE, Goessling W, Daley GQ, North TE. YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.006.

Mechanism for neurotransmitter-receptor matching

Authors:
Hammond-Weinberger DR, Wang Y, Glavis-Bloom A, Spitzer NC
Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1916600117
Epub:
Yes
Abstract:
Synaptic communication requires the expression of functional postsynaptic receptors that match the presynaptically released...
Link:
https://www.pnas.org/content/early/2020/02/07/1916600117
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture, Xenopus
Citation Extract:
Hammond-Weinberger DR, Wang Y, Glavis-Bloom A, Spitzer NC. Mechanism for neurotransmitter-receptor matching. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1916600117.

Cryptic exon activation causes dystrophinopathy in two Chinese families

Authors:
Jin M, Li J-J, Xu G-R, Wang N, Wang Z-Q
Citation:
Eur J Hum Genet. 2020;[epub ahead of print] doi:10.1038/s41431-020-0578-z
Epub:
Yes
Abstract:
The X-linked recessive degenerative disease dystrophinopathy results from variants in the DMD gene. Given the large size and...
Link:
https://www.nature.com/articles/s41431-020-0578-z
Citation Extract:
Jin M, Li J-J, Xu G-R, Wang N, Wang Z-Q. Cryptic exon activation causes dystrophinopathy in two Chinese families. Eur J Hum Genet. 2020;[epub ahead of print] doi:10.1038/s41431-020-0578-z.

Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy

Authors:
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F
Citation:
J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):768-782. doi: 10.1002/jcsm.12542. Epub 2020 Feb 7. PMID: 32031328; PMCID: PMC7296258
Epub:
Yes
Abstract:
BACKGROUND: Spinal muscular atrophy (SMA) is caused by genetic defects in the survival motor neuron 1 (SMN1) gene that lead to...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7296258/
Delivery Method:
s.c. injection
Organism or Cell Type:
mice
Citation Extract:
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F. Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy. J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):768-782. doi: 10.1002/jcsm.12542. Epub 2020 Feb 7. PMID: 32031328; PMCID: PMC7296258.

Assessing intracellular pH regulation in H+-ATPase-rich ionocytes in zebrafish larvae using in vivo ratiometric imaging

Authors:
Yew HM, Zimmer AM, Perry SF
Citation:
J Exper Biol. 2020;[Epub ahead of print] doi:10.1242/jeb.212928
Epub:
Yes
Abstract:
The H+-ATPase rich (HR) cells of zebrafish larvae are a sub-type of ion-transporting cell located on the yolk sac epithelium...
Link:
https://jeb.biologists.org/content/early/2020/02/04/jeb.212928
Organism or Cell Type:
zebrafish
Citation Extract:
Yew HM, Zimmer AM, Perry SF. Assessing intracellular pH regulation in H+-ATPase-rich ionocytes in zebrafish larvae using in vivo ratiometric imaging. J Exper Biol. 2020;[Epub ahead of print] doi:10.1242/jeb.212928.

Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation

Authors:
Tang CT, Zhang QW, Wu S, Tang MY, Liang Q, Lin XL, Gao YJ, Ge ZZ
Citation:
Cell Mol Life Sci. 2020 Feb 1. doi: 10.1007/s00018-020-03465-3. [Epub ahead of print]
Epub:
Yes
Abstract:
Background: Small bowel vascular malformation disease (SBVM) is the most common cause of obscure gastrointestinal bleeding (...
Link:
https://link.springer.com/article/10.1007%2Fs00018-020-03465-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tang CT, Zhang QW, Wu S, Tang MY, Liang Q, Lin XL, Gao YJ, Ge ZZ. Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation. Cell Mol Life Sci. 2020 Feb 1. doi: 10.1007/s00018-020-03465-3. [Epub ahead of print].

Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

Authors:
Sitaraman S, Yadav G, Agarwal V, Jabeen S, Verma S, Jadhav M, Thirumalai V
Citation:
Elife. 2021 Aug 4;10:e68124. doi: 10.7554/eLife.68124. PMID: 34346310; PMCID: PMC8382294
Epub:
Not Epub
Abstract:
Gap junctions between neurons serve as electrical synapses, in addition to conducting metabolites and signaling molecules....
Link:
https://elifesciences.org/articles/68124
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sitaraman S, Yadav G, Agarwal V, Jabeen S, Verma S, Jadhav M, Thirumalai V. Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons. Elife. 2021 Aug 4;10:e68124. doi: 10.7554/eLife.68124. PMID: 34346310; PMCID: PMC8382294.

Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development

Authors:
Rojas-Benítez D, Allende ML
Citation:
Int J Mol Sci. 2020;21(3):925. doi:10.3390/ijms21030925
Epub:
Not Epub
Abstract:
Transfer RNAs (tRNAs) are the most post-transcriptionally modified RNA species. Some of these modifications, especially the...
Link:
https://www.mdpi.com/1422-0067/21/3/925
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rojas-Benítez D, Allende ML. Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development. Int J Mol Sci. 2020;21(3):925. doi:10.3390/ijms21030925.

Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs

Authors:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y
Citation:
J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2019.12.004
Epub:
Yes
Abstract:
The CRISPR/Cas9 technology has been widely utilized for knocking out genes involved in various biological processes in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1673852720300102
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y. Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs. J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2019.12.004.

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