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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12387 scientific papers returned from the database with the search filters currently being used below.

A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity

Authors:
Du LY, Keerthisinghe P, Rolland L, Sung YJ, Darroch H, Linnerz T, Ashimbayeva E, Grant MJ, Kakadia PM, Ramachandran A, Tups A, Spaink HP, Bohlander SK, Cheeseman J, Crosier PS, Astin JW, Warman G, Hall CJ
Citation:
Sci Immunol. 2025 May 23;10(107):eadn3080. doi: 10.1126/sciimmunol.adn3080. Epub 2025 May 23. PMID: 40408429
Epub:
Not Epub
Abstract:
The immune response exhibits strong circadian rhythmicity, with enhanced bacterial clearance often synchronized with an...
Link:
https://www.science.org/doi/10.1126/sciimmunol.adn3080
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Du LY, Keerthisinghe P, Rolland L, Sung YJ, Darroch H, Linnerz T, Ashimbayeva E, Grant MJ, Kakadia PM, Ramachandran A, Tups A, Spaink HP, Bohlander SK, Cheeseman J, Crosier PS, Astin JW, Warman G, Hall CJ. A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity. Sci Immunol. 2025 May 23;10(107):eadn3080. doi: 10.1126/sciimmunol.adn3080. Epub 2025 May 23. PMID: 40408429.

Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium

Authors:
Mukherjee A, Hilzendeger M, Rinvelt A, Fatma S, Schupp M, Dalle Nogare D, Chitnis AB
Citation:
bioRxiv [preprint] 2025.05.17.650326; doi: https://doi.org/10.1101/2025.05.17.650326
Epub:
Not Epub
Abstract:
A prepattern of Fgf signaling triggers formation of epithelial rosettes as protoneuromasts form periodically in the migrating...
Link:
https://www.biorxiv.org/content/10.1101/2025.05.17.650326v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mukherjee A, Hilzendeger M, Rinvelt A, Fatma S, Schupp M, Dalle Nogare D, Chitnis AB. Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium. bioRxiv [preprint] 2025.05.17.650326; doi: https://doi.org/10.1101/2025.05.17.650326.

FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis

Authors:
Wu P, Song N, Xiang Y, Tao Z, Mao B, Guo R, Wang X, Wu D, Zhang Z, Chen X, Ma D, Zhang T, Hao B, Ma J
Citation:
EMBO Mol Med. 2025 May 23. doi: 10.1038/s44321-025-00247-x. Epub ahead of print. PMID: 40410591
Epub:
Not Epub
Abstract:
Congenital ptosis, a genetic disorder involving levator palpebrae muscle dysfunction, is often associated with congenital...
Link:
https://www.embopress.org/doi/full/10.1038/s44321-025-00247-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu P, Song N, Xiang Y, Tao Z, Mao B, Guo R, Wang X, Wu D, Zhang Z, Chen X, Ma D, Zhang T, Hao B, Ma J. FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis. EMBO Mol Med. 2025 May 23. doi: 10.1038/s44321-025-00247-x. Epub ahead of print. PMID: 40410591.

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Authors:
Sanchez AC, Banoukh N, Mensching F, Skibbens RV, Iovine MK
Citation:
Dev Dyn. 2025 May 21. doi: 10.1002/dvdy.70037. Epub ahead of print. PMID: 40396618
Epub:
Not Epub
Abstract:
Background: Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS)....
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.70037
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanchez AC, Banoukh N, Mensching F, Skibbens RV, Iovine MK. Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos. Dev Dyn. 2025 May 21. doi: 10.1002/dvdy.70037. Epub ahead of print. PMID: 40396618.

Regulatory T Cell Function Is Not Affected by Antisense Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer (PPMO)-Mediated TMPRSS2 Truncation

Authors:
Gunne S, Sailer FK, Keutmann L, Schwerdtner M, Moulton HM, Böttcher-Friebertshäuser E, Schiffmann S
Citation:
Drugs and Drug Candidates. 2025; 4(2):25. https://doi.org/10.3390/ddc4020025
Epub:
Not Epub
Abstract:
Background: TMPRSS2 plays an important role in the viral entry mechanisms of influenza viruses and coronaviruses. Therefore,...
Link:
https://www.mdpi.com/2813-2998/4/2/25
Delivery Method:
peptide-linked
Organism or Cell Type:
Human regulatory T cells (Treg) and responder T cells
Citation Extract:
Gunne S, Sailer FK, Keutmann L, Schwerdtner M, Moulton HM, Böttcher-Friebertshäuser E, Schiffmann S. Regulatory T Cell Function Is Not Affected by Antisense Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer (PPMO)-Mediated TMPRSS2 Truncation. Drugs and Drug Candidates. 2025; 4(2):25. https://doi.org/10.3390/ddc4020025.

Conception and Synthesis of Sequence-Coded Morpholinos

Authors:
Pousse B, Al Ouahabi A, Baxter PNW, Charles L, Lutz JF
Citation:
Chemistry. 2025 May 22;31(29):e202501161. doi: 10.1002/chem.202501161. Epub 2025 Apr 29. PMID: 40227092; PMCID: PMC12099184
Epub:
Not Epub
Abstract:
Solid-phase morpholino chemistry was explored as a new route to synthesize abiological sequence-defined oligomers. Two...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12099184/
Delivery Method:
none
Organism or Cell Type:
none
Citation Extract:
Pousse B, Al Ouahabi A, Baxter PNW, Charles L, Lutz JF. Conception and Synthesis of Sequence-Coded Morpholinos. Chemistry. 2025 May 22;31(29):e202501161. doi: 10.1002/chem.202501161. Epub 2025 Apr 29. PMID: 40227092; PMCID: PMC12099184.

Silencing mitochondrial gene expression in living cells

Authors:
Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P
Citation:
Science. 2025 May 22:eadr3498. doi: 10.1126/science.adr3498. Epub ahead of print. PMID: 40403134
Epub:
Not Epub
Abstract:
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key...
Link:
https://www.science.org/doi/10.1126/science.adr3498
Delivery Method:
peptide-linked (pCox41-25)
Organism or Cell Type:
HEK293T cells & isolated mitochondria
Citation Extract:
Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P. Silencing mitochondrial gene expression in living cells. Science. 2025 May 22:eadr3498. doi: 10.1126/science.adr3498. Epub ahead of print. PMID: 40403134.

Redox Homeostasis within the Drug-Resistant Malarial Parasite Digestive Vacuole

Authors:
Willems A, Oertel T, Roepe PD
Citation:
Biochemistry. 2025 May 20;64(10):2247-2261. doi: 10.1021/acs.biochem.4c00750. Epub 2025 May 1. PMID: 40311147; PMCID: PMC12096432
Epub:
Not Epub
Abstract:
We have developed a cost-effective strategy for the complete synthesis of azetidinyl coumarin fluorophore derivatives that...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12096432/
Delivery Method:
none
Organism or Cell Type:
intraerythrocytic Plasmodium falciparum
Citation Extract:
Willems A, Oertel T, Roepe PD. Redox Homeostasis within the Drug-Resistant Malarial Parasite Digestive Vacuole. Biochemistry. 2025 May 20;64(10):2247-2261. doi: 10.1021/acs.biochem.4c00750. Epub 2025 May 1. PMID: 40311147; PMCID: PMC12096432.

Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy

Authors:
Nicastro M, Vermeer AMC, Postema PG, Tadros R, Bowling FZ, Aegisdottir HM, Tragante V, Mach L, Postma AV, Lodder EM, van Duijvenboden K, Zwart R, Beekman L, Wu L, Jurgens SJ, van der Zwaag PA, Alders M, Allouba M, Aguib Y, Santome JL, de Una D, Monserrat L, Miranda AMA, Kanemaru K, Cranley J, van Zeggeren IE, Aronica EMA, Ripolone M, Zanotti S, Sveinbjornsson G, Ivarsdottir EV, Hólm H, Guðbjartsson DF, Skúladóttir ÁT, Stefánsson K, Nadauld L, Knowlton KU, Ostrowski SR, Sørensen E, Vesterager Pedersen OB, Ghouse J, Rand SA, Bundgaard H, Ullum H, Erikstrup C, Aagaard B et al.
Citation:
Am J Hum Genet. 2025 May 20:S0002-9297(25)00179-X. doi: 10.1016/j.ajhg.2025.04.016. Epub ahead of print. PMID: 40409267
Epub:
Not Epub
Abstract:
POPDC2 encodes the Popeye domain-containing protein 2, which has an important role in cardiac pacemaking and conduction, due in...
Link:
https://www.cell.com/ajhg/fulltext/S0002-9297(25)00179-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nicastro M, Vermeer AMC, Postema PG, Tadros R, Bowling FZ, Aegisdottir HM, Tragante V, Mach L, Postma AV, Lodder EM, van Duijvenboden K, Zwart R, Beekman L, Wu L, Jurgens SJ, van der Zwaag PA, Alders M, Allouba M, Aguib Y, Santome JL, de Una D, Monserrat L, Miranda AMA, Kanemaru K, Cranley J, van Zeggeren IE, Aronica EMA, Ripolone M, Zanotti S, Sveinbjornsson G, Ivarsdottir EV, Hólm H, Guðbjartsson DF, Skúladóttir ÁT, Stefánsson K, Nadauld L, Knowlton KU, Ostrowski SR, Sørensen E, Vesterager Pedersen OB, Ghouse J, Rand SA, Bundgaard H, Ullum H, Erikstrup C, Aagaard B et al.. Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy. Am J Hum Genet. 2025 May 20:S0002-9297(25)00179-X. doi: 10.1016/j.ajhg.2025.04.016. Epub ahead of print. PMID: 40409267.

Novel centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium

Authors:
Sheridan J, Grata A, Dorr J, Suva EE, Bresteau E, Mitchell LR, Hassan O, Mitchell B
Citation:
Dev Biol. 2025 May 15:S0012-1606(25)00134-4. doi: 10.1016/j.ydbio.2025.05.011. Epub ahead of print. PMID: 40381709
Epub:
Not Epub
Abstract:
The skin of Xenopus embryos contains numerous multiciliated cells (MCCs), which collectively generate a directed fluid flow...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160625001344
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Sheridan J, Grata A, Dorr J, Suva EE, Bresteau E, Mitchell LR, Hassan O, Mitchell B. Novel centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium. Dev Biol. 2025 May 15:S0012-1606(25)00134-4. doi: 10.1016/j.ydbio.2025.05.011. Epub ahead of print. PMID: 40381709.

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