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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12156 scientific papers returned from the database with the search filters currently being used below.

Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms

Authors:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Andricek A, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P
Citation:
PLoS Biol. 2026 Jan 5;24(1):e3003583. doi: 10.1371/journal.pbio.3003583. PMID: 41490055; PMCID: PMC12768278
Epub:
Not Epub
Abstract:
Foxi1 is a master regulator of ionocytes (ISCs/INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β-...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12768278/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Andricek A, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P. Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanisms. PLoS Biol. 2026 Jan 5;24(1):e3003583. doi: 10.1371/journal.pbio.3003583. PMID: 41490055; PMCID: PMC12768278.

MMS22L is a novel key actor of normal and pathological erythropoiesis

Authors:
Colin E, Ferrer-Vicens I, Brook D, Salma M, Andrieu-Soler C, Bayard E, Fernandes A, Brouzes C, Lefèvre C, Duval R, Dussiot M, Trovati T, Courtois G, Azouzi S, Zarhrate M, Lambilliotte A, Park S, Carpentier B, Colard M, Manceau S, Moshous D, Mayeux P, Gautier EF, Miccio A, Soulier J, Vainchenker W, Shlush L, Da Costa L, Frayne J, Soler E, Hermine O, Couronné L
Citation:
Hemasphere. 2025 Dec 23;9(12):e70264. doi: 10.1002/hem3.70264. PMID: 41446536; PMCID: PMC12723439
Epub:
Not Epub
Abstract:
The emergence of next-generation sequencing techniques has led to the genetic characterization of numerous congenital erythroid...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12723439/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Colin E, Ferrer-Vicens I, Brook D, Salma M, Andrieu-Soler C, Bayard E, Fernandes A, Brouzes C, Lefèvre C, Duval R, Dussiot M, Trovati T, Courtois G, Azouzi S, Zarhrate M, Lambilliotte A, Park S, Carpentier B, Colard M, Manceau S, Moshous D, Mayeux P, Gautier EF, Miccio A, Soulier J, Vainchenker W, Shlush L, Da Costa L, Frayne J, Soler E, Hermine O, Couronné L. MMS22L is a novel key actor of normal and pathological erythropoiesis. Hemasphere. 2025 Dec 23;9(12):e70264. doi: 10.1002/hem3.70264. PMID: 41446536; PMCID: PMC12723439.

Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development

Authors:
Oak MS, Stock M, Janeva A, Mezes M, Hynes-Allen AM, Straub T, Forné I, Ettinger A, Hamperl S, Imhof A, van den Ameele J, Scialdone A, Hörmanseder E
Citation:
Nat Commun. 2025 Dec 19;16(1):11334. doi: 10.1038/s41467-025-67692-7. PMID: 41419741; PMCID: PMC12722762
Epub:
Not Epub
Abstract:
In vertebrate embryos, gene expression is first initiated at zygotic genome activation (ZGA). Maternally expressed...
Link:
https://www.nature.com/articles/s41467-025-67692-7
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Oak MS, Stock M, Janeva A, Mezes M, Hynes-Allen AM, Straub T, Forné I, Ettinger A, Hamperl S, Imhof A, van den Ameele J, Scialdone A, Hörmanseder E. Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development. Nat Commun. 2025 Dec 19;16(1):11334. doi: 10.1038/s41467-025-67692-7. PMID: 41419741; PMCID: PMC12722762.

Glis3 as a critical regulator of Pit1-lineages and renal functions

Authors:
Rurale G, Gentile I, Persani L, Marelli F
Citation:
J Mol Med (Berl). 2025 Dec 29;104(1):19. doi: 10.1007/s00109-025-02611-3. PMID: 41457180; PMCID: PMC12745328
Epub:
Not Epub
Abstract:
The Krüppel-like GLIS3 transcription factor acts as an effector on the sonic hedgehog (Shh) pathway, regulating several...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12745328/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rurale G, Gentile I, Persani L, Marelli F. Glis3 as a critical regulator of Pit1-lineages and renal functions. J Mol Med (Berl). 2025 Dec 29;104(1):19. doi: 10.1007/s00109-025-02611-3. PMID: 41457180; PMCID: PMC12745328.

Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids

Authors:
Faravelli I, Rinchetti P, Tambalo M, Simutin I, Mapelli L, Mancinelli S, Miotto M, Rizzuti M, D'Angelo A, Cordiglieri C, Forotti G, Peano C, Kunderfranco P, Calandriello L, Comi GP, Paraboschi E, Pali E, Beatrice F, D'Angelo E, Przedborski S, Nizzardo M, Lodato S, Corti S
Citation:
Nat Commun. 2025 Dec 21. doi: 10.1038/s41467-025-67725-1. Epub ahead of print. PMID: 41423447
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is a severe neurological disease caused by mutations in the SMN1 gene, characterized by early...
Link:
https://www.nature.com/articles/s41467-025-67725-1
Delivery Method:
R6 peptide-linked
Organism or Cell Type:
SMA type 1 patient-derived spinal cord and cerebral organoids
Citation Extract:
Faravelli I, Rinchetti P, Tambalo M, Simutin I, Mapelli L, Mancinelli S, Miotto M, Rizzuti M, D'Angelo A, Cordiglieri C, Forotti G, Peano C, Kunderfranco P, Calandriello L, Comi GP, Paraboschi E, Pali E, Beatrice F, D'Angelo E, Przedborski S, Nizzardo M, Lodato S, Corti S. Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids. Nat Commun. 2025 Dec 21. doi: 10.1038/s41467-025-67725-1. Epub ahead of print. PMID: 41423447.

Behavioral improvement in dystrophic mdx23 mouse following repeated antisense oligonucleotides injections

Authors:
Aghaeipour A, Mitsogiannis M, Fergus C, Tetorou K, Gileadi T, Stojek E, Talavera S, Singh S, Siddle M, Prendeville J, Sokolowska E, Kelly V, Morgan J, Montanaro F, Muntoni F
Citation:
Mol Ther Nucleic Acids. 2025 Oct 24;36(4):102750. doi: 10.1016/j.omtn.2025.102750. PMID: 41467120; PMCID: PMC12744854
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the DMD gene that disrupt the...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12744854/
Delivery Method:
intracisternal magna (i.c.m.) and intraperitoneal (i.p.) injection
Organism or Cell Type:
mdx23 mice
Citation Extract:
Aghaeipour A, Mitsogiannis M, Fergus C, Tetorou K, Gileadi T, Stojek E, Talavera S, Singh S, Siddle M, Prendeville J, Sokolowska E, Kelly V, Morgan J, Montanaro F, Muntoni F. Behavioral improvement in dystrophic mdx23 mouse following repeated antisense oligonucleotides injections. Mol Ther Nucleic Acids. 2025 Oct 24;36(4):102750. doi: 10.1016/j.omtn.2025.102750. PMID: 41467120; PMCID: PMC12744854.

Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation

Authors:
Chen YY, Rodriguez K, Alexander AK, Xu X, Papas B, Estermann MA, Yao HH
Citation:
Sci Adv. 2026 Jan 2;12(1):eaea7403. doi: 10.1126/sciadv.aea7403. Epub 2026 Jan 2. PMID: 41481707; PMCID: PMC12758517
Epub:
Not Epub
Abstract:
Sex determination of mammalian gonads hinges upon sex-specific differentiation of gonadal supporting cells: Sertoli cells in...
Link:
https://www.science.org/doi/10.1126/sciadv.aea7403
Delivery Method:
Vivo-Morpholino culture
Organism or Cell Type:
C57BL/6J mouse gonads
Citation Extract:
Chen YY, Rodriguez K, Alexander AK, Xu X, Papas B, Estermann MA, Yao HH. Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation. Sci Adv. 2026 Jan 2;12(1):eaea7403. doi: 10.1126/sciadv.aea7403. Epub 2026 Jan 2. PMID: 41481707; PMCID: PMC12758517.

Giardiavirus rewires host translation and glycolytic metabolism to support its replication in Giardia duodenalis

Authors:
Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P
Citation:
Virulence. 2026 Dec;17(1):2605746. doi: 10.1080/21505594.2025.2605746. Epub 2025 Dec 24. PMID: 41445118; PMCID: PMC12758212
Epub:
Not Epub
Abstract:
Giardia duodenalis is an intestinal protozoan parasite responsible for giardiasis, a disease primarily characterized by...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12758212/
Delivery Method:
electroporation
Organism or Cell Type:
Giardia duodenalis
Citation Extract:
Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P. Giardiavirus rewires host translation and glycolytic metabolism to support its replication in Giardia duodenalis. Virulence. 2026 Dec;17(1):2605746. doi: 10.1080/21505594.2025.2605746. Epub 2025 Dec 24. PMID: 41445118; PMCID: PMC12758212.

Investigating the Role of Zebrafish Retinoschisin Homologs Rs1a and Rs1b During Retinal Development

Authors:
van der Veen I, Koster C, Brink JBT, Kamermans M, Boon CJF
Citation:
Dev Neurobiol. 2026 Jan;86(1):e23012. doi: 10.1002/dneu.23012. PMID: 41171855; PMCID: PMC12578269
Epub:
Not Epub
Abstract:
Deficiency in the retinoschisin protein (RS1) causes X-linked juvenile retinoschisis (XLRS), a retinal degenerative disease...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12578269/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
van der Veen I, Koster C, Brink JBT, Kamermans M, Boon CJF. Investigating the Role of Zebrafish Retinoschisin Homologs Rs1a and Rs1b During Retinal Development. Dev Neurobiol. 2026 Jan;86(1):e23012. doi: 10.1002/dneu.23012. PMID: 41171855; PMCID: PMC12578269.

Diet-supplemented probiotic Bacillus velezensis protects against viral infection via the lipopeptide surfactin in zebrafish

Authors:
Zhou W, Liang H, Meng D, Xu S, Zhang Y, Zhu H, Wang Y, Yang Y, Zhang Z, Yao Y, Xu X, Ding Q, Li M, Zhou Z, Ran C
Citation:
J Nutr. 2025 Dec 27:101296. doi: 10.1016/j.tjnut.2025.101296. Epub ahead of print. PMID: 41461267
Epub:
Not Epub
Abstract:
Background: Probiotic nutrition has the potential to improve health and prevents diseases, and probiotics such as Bacillus spp...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0022316625008028
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou W, Liang H, Meng D, Xu S, Zhang Y, Zhu H, Wang Y, Yang Y, Zhang Z, Yao Y, Xu X, Ding Q, Li M, Zhou Z, Ran C. Diet-supplemented probiotic Bacillus velezensis protects against viral infection via the lipopeptide surfactin in zebrafish. J Nutr. 2025 Dec 27:101296. doi: 10.1016/j.tjnut.2025.101296. Epub ahead of print. PMID: 41461267.

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