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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12165 scientific papers returned from the database with the search filters currently being used below.
There are 12165 scientific papers returned from the database with the search filters currently being used below.
AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos
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Citation:
J Hazard Mater. 2019 Oct 25:121521. doi: 10.1016/j.jhazmat.2019.121521. [Epub ahead of print] Epub:
Yes Abstract:
Trichloroethylene (TCE), a widely used chlorinated solvent, is a common environmental pollutant. Current evidence shows that... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Jin H, Ji C, Ren F, Aniagu S, Tong J, Jiang Y, Chen T. AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. J Hazard Mater. 2019 Oct 25:121521. doi: 10.1016/j.jhazmat.2019.121521. [Epub ahead of print]. |
Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model
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Citation:
J Am Soc Nephrol. 2019 Nov 1. pii: ASN.2019020125. doi: 10.1681/ASN.2019020125. [Epub ahead of print] Epub:
Yes Abstract:
BACKGROUND: Lowe syndrome (LS) is an X-linked recessive disorder caused by mutations in OCRL, which encodes the enzyme OCRL.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gliozzi ML, Espiritu EB, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, Weisz OA. Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model. J Am Soc Nephrol. 2019 Nov 1. pii: ASN.2019020125. doi: 10.1681/ASN.2019020125. [Epub ahead of print]. |
Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment
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Citation:
J Clin Med. 2019;8(11):1811. doi:10.3390/jcm8111811 Epub:
Not Epub Abstract:
Congenital lactic acidosis (CLA) is a rare condition in most instances due to a range of inborn errors of metabolism that... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: patient fibroblasts Citation Extract: Bravo-Alonso I, Navarrete R, Vega AI, Ruíz-Sala P, Silva MTG, Martín-Hernández E, Quijada-Fraile P, Belanger-Quintana A, Stanescu S, Bueno M, Vitoria I, Toledo L, Couce ML, García-Jiménez I, Ramos-Ruiz R, Martín MA, Desviat LR, Ugarte M, Pérez-Cerdá C, Merinero B, Pérez B, Rodríguez-Pombo P. Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment. J Clin Med. 2019;8(11):1811. doi:10.3390/jcm8111811. |
An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
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Citation:
Nat Comm. 2019;10:5012. doi:10.1038/s41467-019-12906-y Epub:
Not Epub Abstract:
Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small... Delivery Method:
Vivo-Morpholino with anionic delivery polymer PPAA Organism or Cell Type:
cell culture: human microvascular endothelial cells HMVEC Citation Extract: Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL. An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Nat Comm. 2019;10:5012. doi:10.1038/s41467-019-12906-y. |
A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing
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Citation:
PLoS Genet. 2019;15(10):e1008460. doi:10.1371/journal.pgen.1008460 Epub:
Not Epub Abstract:
Malfunction of pre-mRNA processing factors are linked to several human diseases including cancer and neurodegeneration. Here we... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen T, Zhang B, Ziegenhals T, Prusty AB, Fröhler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W. A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLoS Genet. 2019;15(10):e1008460. doi:10.1371/journal.pgen.1008460. |
Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation
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Citation:
Mol Biol Cell. 2020 Feb 1;31(3):167-183. doi: 10.1091/mbc.E19-07-0408. Epub 2019 Dec 18. PMID: 31851597; PMCID: PMC7001481 Epub:
Not Epub Abstract:
Protein glycosylation plays essential roles in protein structure, stability, and activity such as cell adhesion. The cadherin... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Graham JB, Sunryd JC, Mathavan K, Weir E, Larsen ISB, Halim A, Clausen H, Cousin H, Alfandari D, Hebert DN. Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation. Mol Biol Cell. 2020 Feb 1;31(3):167-183. doi: 10.1091/mbc.E19-07-0408. Epub 2019 Dec 18. PMID: 31851597; PMCID: PMC7001481. |
Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing
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Citation:
Int J Mol Sci. 2019;20(21):5434. doi:10.3390/ijms20215434 Epub:
Not Epub Abstract:
Spinocerebellar ataxia type 3 (SCA3) is a devastating neurodegenerative disease for which there is currently no cure, nor... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: SCA3 patient-derived dermal fibroblasts Citation Extract: McIntosh CS, Aung-Htut MT, Fletcher S, Wilton SD. Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing. Int J Mol Sci. 2019;20(21):5434. doi:10.3390/ijms20215434. |
Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation
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Citation:
Cell Rep. 2019;29:1082-98. doi:10.1016/j.celrep.2019.09.033 Epub:
Not Epub Abstract:
Chondrolectin (Chodl) is needed for motor axon extension in zebrafish and is dysregulated in mouse models of spinal muscular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Oprişoreanu A-M, Smith HL, Arya S, Webster R, Zhong Z, Wehner D, Cardozo MJ, Becker T, Talbot K, Becker CG. Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation. Cell Rep. 2019;29:1082-98. doi:10.1016/j.celrep.2019.09.033. |
Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo
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Citation:
Nat Comm. 2019;10:4911 doi:10.1038/s41467-019-12839-6 Epub:
Not Epub Abstract:
Foxg constitutes a regulatory loop with Fgf8 and plays an important role in the development of anterior placodes and the... Delivery Method:
microinjection Organism or Cell Type:
Ciona robusta (AKA C. intestinalis; ascidian) Citation Extract: Liu B, Satou Y. Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo. Nat Comm. 2019;10:4911 doi:10.1038/s41467-019-12839-6. |
Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation
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Citation:
Sci Rep. 2019;9:15645 doi:10.1038/s41598-019-52218-1 Epub:
Not Epub Abstract:
The activation of distinct branches of the Wnt signaling network is essential for regulating early vertebrate development.... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Puzik K, Tonnier V, Opper I, Eckert A, Zhou L, Kratzer M-C, le Noble F, Nienhaus GU, Gradl D. Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation. Sci Rep. 2019;9:15645 doi:10.1038/s41598-019-52218-1. |