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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12419 scientific papers returned from the database with the search filters currently being used below.

Panorama of ancient metazoan macromolecular complexes

Authors:
Wan C, Borgeson B, Phanse S, Tu F, Drew K, Clark G, Xiong X, Kagan O, Kwan J, Bezginov A, Chessman K, Pal S, Cromar G, Papoulas O, Ni Z, Boutz DR, Stoilova S, Havugimana PC, Guo X, Malty RH, Sarov M, Greenblatt J, Babu M, Derry WB, R Tillier E, Wallingford JB, Parkinson J, Marcotte EM, Emili A
Citation:
Nature. 2015 Sep 7. doi: 10.1038/nature14877. [Epub ahead of print]
Epub:
Yes
Abstract:
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Wan C, Borgeson B, Phanse S, Tu F, Drew K, Clark G, Xiong X, Kagan O, Kwan J, Bezginov A, Chessman K, Pal S, Cromar G, Papoulas O, Ni Z, Boutz DR, Stoilova S, Havugimana PC, Guo X, Malty RH, Sarov M, Greenblatt J, Babu M, Derry WB, R Tillier E, Wallingford JB, Parkinson J, Marcotte EM, Emili A. Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 7. doi: 10.1038/nature14877. [Epub ahead of print].

A cationic morpholino antisense oligomer conjugate: synthesis, cellular uptake and inhibition of Gli1 in the hedgehog signalling pathway

Authors:
Pattanayak S, Khatra H, Sahab S, Sinha S
Citation:
RSC Adv. 2014. 4:1951-1954. doi:10.1039/C3RA45257C
Epub:
Not Epub
Abstract:
A guanidinium-linked morpholino pentamer is synthesized and evaluated for cellular penetration properties. A regular morpholino...
Organism or Cell Type:
cell culture
Citation Extract:
Pattanayak S, Khatra H, Sahab S, Sinha S. A cationic morpholino antisense oligomer conjugate: synthesis, cellular uptake and inhibition of Gli1 in the hedgehog signalling pathway. RSC Adv. 2014. 4:1951-1954. doi:10.1039/C3RA45257C .

Synthesis of morpholino monomers, chlorophosphoramidate monomers, and solid-phase synthesis of short morpholino oligomers

Authors:
Bhadra J, Pattanayak S, Sinha S
Citation:
Curr Protoc Nucleic Acid Chem. 2015;62:4.65.1-4.65.26. doi: 10.1002/0471142700.nc0465s62
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMOs) are a highly capable class of synthetic antisense oligonucleotides that are used...
Citation Extract:
Bhadra J, Pattanayak S, Sinha S. Synthesis of morpholino monomers, chlorophosphoramidate monomers, and solid-phase synthesis of short morpholino oligomers. Curr Protoc Nucleic Acid Chem. 2015;62:4.65.1-4.65.26. doi: 10.1002/0471142700.nc0465s62.

DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome

Authors:
Slaats GG, Saldivar JC, Bacal J, Zeman MK, Kile AC, Hynes AM, Srivastava S, Nazmutdinova J, Ouden Kd, Zagers MS, Foletto V, Verhaar MC, Miles C, Sayer JA, Cimprich KA, Giles RH
Citation:
J Clin Invest. 2015 Sep 1;125(9):3657-66. doi: 10.1172/JCI80657. Epub 2015 Aug 24
Epub:
Not Epub
Abstract:
Juvenile ciliopathy syndromes that are associated with renal cysts and premature renal failure are commonly the result of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Slaats GG, Saldivar JC, Bacal J, Zeman MK, Kile AC, Hynes AM, Srivastava S, Nazmutdinova J, Ouden Kd, Zagers MS, Foletto V, Verhaar MC, Miles C, Sayer JA, Cimprich KA, Giles RH. DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome. J Clin Invest. 2015 Sep 1;125(9):3657-66. doi: 10.1172/JCI80657. Epub 2015 Aug 24.

TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy

Authors:
Fiorillo AA, Heier CR, Novak JS, Tully CB, Brown KJ, Uaesoontrachoon K, Vila MC, Ngheim PP, Bello L, Kornegay JN, Angelini C, Partridge TA, Nagaraju K, Hoffman EP
Citation:
Cell Rep. 2015 Sep 8;12(10):1678-90. doi: 10.1016/j.celrep.2015.07.066. Epub 2015 Aug 28
Epub:
Not Epub
Abstract:
The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and...
Delivery Method:
injection
Organism or Cell Type:
mice, mdx
Citation Extract:
Fiorillo AA, Heier CR, Novak JS, Tully CB, Brown KJ, Uaesoontrachoon K, Vila MC, Ngheim PP, Bello L, Kornegay JN, Angelini C, Partridge TA, Nagaraju K, Hoffman EP. TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy. Cell Rep. 2015 Sep 8;12(10):1678-90. doi: 10.1016/j.celrep.2015.07.066. Epub 2015 Aug 28.

An equation to estimate the difference between theoretically predicted and SDS PAGE-displayed molecular weights for an acidic peptide

Authors:
Guan Y, Zhu Q, Huang D, Zhao S, Jan Lo L, Peng J
Citation:
Sci Rep. 2015 Aug 27;5:13370. doi: 10.1038/srep13370
Epub:
Not Epub
Abstract:
The molecular weight (MW) of a protein can be predicted based on its amino acids (AA) composition. However, in many cases a non...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guan Y, Zhu Q, Huang D, Zhao S, Jan Lo L, Peng J. An equation to estimate the difference between theoretically predicted and SDS PAGE-displayed molecular weights for an acidic peptide. Sci Rep. 2015 Aug 27;5:13370. doi: 10.1038/srep13370.

Telomerase Is Essential for Zebrafish Heart Regeneration

Authors:
Bednarek D, González-Rosa JM, Guzmán-Martínez G, Gutiérrez-Gutiérrez Ó, Aguado T, Sánchez-Ferrer C, Marques IJ, Galardi-Castilla M, de Diego I, Gómez MJ, Cortés A, Zapata A, Jiménez-Borreguero LJ, Mercader N, Flores I
Citation:
Cell Rep. 2015 Sep 8;12(10):1691-703. doi: 10.1016/j.celrep.2015.07.064. Epub 2015 Aug 28
Epub:
Not Epub
Abstract:
After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast,...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Bednarek D, González-Rosa JM, Guzmán-Martínez G, Gutiérrez-Gutiérrez Ó, Aguado T, Sánchez-Ferrer C, Marques IJ, Galardi-Castilla M, de Diego I, Gómez MJ, Cortés A, Zapata A, Jiménez-Borreguero LJ, Mercader N, Flores I. Telomerase Is Essential for Zebrafish Heart Regeneration. Cell Rep. 2015 Sep 8;12(10):1691-703. doi: 10.1016/j.celrep.2015.07.064. Epub 2015 Aug 28.

Transcriptome analysis of severe hypoxic stress during development in zebrafish

Authors:
Woods IG, Imam FB
Citation:
Genomics Data. 2015;6:83-88. doi:10.1016/j.gdata.2015.07.025
Epub:
Not Epub
Abstract:
Hypoxia causes critical cellular injury both in early human development and in adulthood, leading to cerebral palsy, stroke,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Woods IG, Imam FB. Transcriptome analysis of severe hypoxic stress during development in zebrafish. Genomics Data. 2015;6:83-88. doi:10.1016/j.gdata.2015.07.025.

Polyamine biosynthesis is critical for growth and differentiation of the pancreas

Authors:
Mastracci TL, Robertson MA, Mirmira RG, Anderson RM
Citation:
Sci Rep. 2015 Aug 24;5:13269. doi: 10.1038/srep13269
Epub:
Not Epub
Abstract:
The pancreas, in most studied vertebrates, is a compound organ with both exocrine and endocrine functions. The exocrine...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mastracci TL, Robertson MA, Mirmira RG, Anderson RM. Polyamine biosynthesis is critical for growth and differentiation of the pancreas. Sci Rep. 2015 Aug 24;5:13269. doi: 10.1038/srep13269.

Chamber identity programs drive early functional partitioning of the heart

Authors:
Mosimann C, Panáková D, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI
Citation:
Nat Commun. 2015 Aug 26;6:8146. doi: 10.1038/ncomms9146
Epub:
Not Epub
Abstract:
The vertebrate heart muscle (myocardium) develops from the first heart field (FHF) and expands by adding second heart field (...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mosimann C, Panáková D, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26;6:8146. doi: 10.1038/ncomms9146.

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