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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12455 scientific papers returned from the database with the search filters currently being used below.

Ciliary localization of a light-activated neuronal GPCR shapes behavior

Authors:
Winans AM, Friedmann D, Stanley C, Xiao T, Liu TL, Chang CJ, Isacoff EY
Citation:
Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2311131120. doi: 10.1073/pnas.2311131120. Epub 2023 Oct 16
Epub:
Not Epub
Abstract:
Many neurons in the central nervous system produce a single primary cilium that serves as a specialized signaling organelle....
Link:
https://www.pnas.org/doi/10.1073/pnas.2311131120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Winans AM, Friedmann D, Stanley C, Xiao T, Liu TL, Chang CJ, Isacoff EY. Ciliary localization of a light-activated neuronal GPCR shapes behavior. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2311131120. doi: 10.1073/pnas.2311131120. Epub 2023 Oct 16.

A novel role for the chloride intracellular channel protein Clic5 in ciliary function

Authors:
Ott E, Hoff S, Indorf L, Ditengou FA, Müller J, Renschler G, Lienkamp SS, Kramer-Zucker A, Bergmann C, Epting D
Citation:
Sci Rep. 2023 Oct 17;13(1):17647. doi: 10.1038/s41598-023-44235-y
Epub:
Not Epub
Abstract:
CLIC5 belongs to a family of ion channels with six members reported so far. In vertebrates, the CLIC5 gene encodes two...
Link:
https://www.nature.com/articles/s41598-023-44235-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ott E, Hoff S, Indorf L, Ditengou FA, Müller J, Renschler G, Lienkamp SS, Kramer-Zucker A, Bergmann C, Epting D. A novel role for the chloride intracellular channel protein Clic5 in ciliary function. Sci Rep. 2023 Oct 17;13(1):17647. doi: 10.1038/s41598-023-44235-y.

Xbra modulates the activity of linker region phosporlated Smad1 during Xenopus somitogenesis

Authors:
Kim J, Kumar S, Umair Z, Goutam RS, Lee U
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.11.561863
Epub:
Not Epub
Abstract:
The Bmp/Smad1 pathway plays a crucial role in developmental processes and tissue homeostasis. Mitogen-activated protein kinase...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.11.561863v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim J, Kumar S, Umair Z, Goutam RS, Lee U. Xbra modulates the activity of linker region phosporlated Smad1 during Xenopus somitogenesis. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.11.561863.

Rtf1-dependent transcriptional pausing regulates cardiogenesis

Authors:
Langenbacher AD, Fei Lu, Tsang L, Yi Z, Huang S, Keer B, Tian X, Eide A, Pellegrini M, Nakano H, Nakano A, Chen J-N
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.13.562296
Epub:
Not Epub
Abstract:
During heart development, a well-characterized network of transcription factors initiates cardiac gene expression and defines...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.13.562296v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Langenbacher AD, Fei Lu, Tsang L, Yi Z, Huang S, Keer B, Tian X, Eide A, Pellegrini M, Nakano H, Nakano A, Chen J-N. Rtf1-dependent transcriptional pausing regulates cardiogenesis. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.13.562296.

Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs

Authors:
Das A, Ghosh A, Kundu J, Egli M, Manoharan M, Sinha S
Citation:
J Org Chem. 2023 Oct 16. doi: 10.1021/acs.joc.3c01658. Online ahead of print
Epub:
Yes
Abstract:
Successful syntheses of chlorophosphoramidate morpholino monomers containing tricyclic cytosine analogs phenoxazine, G-clamp,...
Link:
https://pubs.acs.org/doi/10.1021/acs.joc.3c01658
Citation Extract:
Das A, Ghosh A, Kundu J, Egli M, Manoharan M, Sinha S. Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs. J Org Chem. 2023 Oct 16. doi: 10.1021/acs.joc.3c01658. Online ahead of print.

Crb3 is required to organize the apical domain of multiciliated cells

Authors:
Burcklé C, Raitière J, Michaux G, Kodjabachian L, Bivic AL
Citation:
J Cell Sci. 2023 Oct 16:jcs.261046. doi: 10.1242/jcs.261046. Online ahead of print
Epub:
Yes
Abstract:
Cell shape changes mainly rely on the remodeling of the actin cytoskeleton. Multiciliated cells (MCCs) of the mucociliary...
Link:
https://journals.biologists.com/jcs/article-abstract/doi/10.1242/jcs.261046/333513/Crb3-is-required-to-organize-the-apical-domain-of
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Burcklé C, Raitière J, Michaux G, Kodjabachian L, Bivic AL. Crb3 is required to organize the apical domain of multiciliated cells. J Cell Sci. 2023 Oct 16:jcs.261046. doi: 10.1242/jcs.261046. Online ahead of print.

Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors

Authors:
Gambles MT, Sborov D, Shami P, Yang J, Kopeček J
Citation:
Macromol Biosci. 2023 Oct 15:e2300375. doi: 10.1002/mabi.202300375. Online ahead of print
Epub:
Yes
Abstract:
Drug-Free Macromolecular Therapeutics (DFMT) utilizes modified monoclonal antibodies (or antibody fragments) to generate...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mabi.202300375
Delivery Method:
cell bathing; injection
Organism or Cell Type:
cell culture: Raji (B cells); mice
Citation Extract:
Gambles MT, Sborov D, Shami P, Yang J, Kopeček J. Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors. Macromol Biosci. 2023 Oct 15:e2300375. doi: 10.1002/mabi.202300375. Online ahead of print.

Chaperone-mediated autophagy protects against hyperglycemic stress

Authors:
Vélez EJ, Schnebert S, Goguet M, Balbuena-Pecino S, Dias K, Beauclair L, Fontagné-Dicharry S, Véron V, Depincé A, Beaumatin F, Herpin A, Seiliez I
Citation:
Autophagy. 2023 Oct 5:[Epub ahead of print]. doi:10.1080/15548627.2023.2267415
Epub:
Yes
Abstract:
Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homeostasis and metabolism...
Link:
https://www.tandfonline.com/doi/figure/10.1080/15548627.2023.2267415
Organism or Cell Type:
Oncorhynchus mykiss (rainbow trout)
Citation Extract:
Vélez EJ, Schnebert S, Goguet M, Balbuena-Pecino S, Dias K, Beauclair L, Fontagné-Dicharry S, Véron V, Depincé A, Beaumatin F, Herpin A, Seiliez I. Chaperone-mediated autophagy protects against hyperglycemic stress. Autophagy. 2023 Oct 5:[Epub ahead of print]. doi:10.1080/15548627.2023.2267415.

Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification

Authors:
Hu P, Wang B, Jin D, Gu Y, He H, Meng X, Zhu W, Chiang DY, Li W, MacRae CA, Zu Y
Citation:
Cell Mol Life Sci. 2023;80:317. doi:10.1007/s00018-023-04933-2
Epub:
Not Epub
Abstract:
Hox genes orchestrate the segmental specification of the muscular circulatory system in invertebrates but it has not proven...
Link:
https://link.springer.com/article/10.1007/s00018-023-04933-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hu P, Wang B, Jin D, Gu Y, He H, Meng X, Zhu W, Chiang DY, Li W, MacRae CA, Zu Y. Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification. Cell Mol Life Sci. 2023;80:317. doi:10.1007/s00018-023-04933-2.

An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis

Authors:
González-Llera L, Sobrido-Cameán D, Quelle-Regaldie A, Sánchez L, Barreiro-Iglesias A
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.05.561099
Epub:
Not Epub
Abstract:
The study of neurogenesis is essential to understand fundamental developmental processes and for the development of cell...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.05.561099v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
González-Llera L, Sobrido-Cameán D, Quelle-Regaldie A, Sánchez L, Barreiro-Iglesias A. An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.05.561099.

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