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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12419 scientific papers returned from the database with the search filters currently being used below.

Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52

Authors:
Cale JM, Greer K, Fletcher S, Wilton SD
Citation:
Int J Mol Sci. 2021;22(7):3479. doi:10.3390/ijms22073479
Epub:
Not Epub
Abstract:
Marfan syndrome is one of the most common dominantly inherited connective tissue disorders, affecting 2–3 in 10,000 individuals...
Link:
https://www.mdpi.com/1422-0067/22/7/3479
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: primary Marfan fibroblasts
Citation Extract:
Cale JM, Greer K, Fletcher S, Wilton SD. Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52. Int J Mol Sci. 2021;22(7):3479. doi:10.3390/ijms22073479.

RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis

Authors:
Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN
Citation:
Dev Cell. 2021 Mar 16:S1534-5807(21)00203-3. doi: 10.1016/j.devcel.2021.03.006. Online ahead of print
Epub:
Not Epub
Abstract:
Adenosine N6-methylation (m6A) is one of the most pervasive mRNA modifications, and yet the physiological significance of m6A...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580721002033
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN. RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis. Dev Cell. 2021 Mar 16:S1534-5807(21)00203-3. doi: 10.1016/j.devcel.2021.03.006. Online ahead of print.

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exon

Authors:
Gordon PM, Hamid F, Makeyev EV, Houart C
Citation:
Nat Comm. 2021;12(1):1918. doi:10.1038/s41467-021-22098-z
Epub:
Not Epub
Abstract:
The RNA-binding protein SFPQ plays an important role in neuronal development and has been associated with several...
Link:
https://www.nature.com/articles/s41467-021-22098-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gordon PM, Hamid F, Makeyev EV, Houart C. A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exon. Nat Comm. 2021;12(1):1918. doi:10.1038/s41467-021-22098-z.

Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish

Authors:
Sipka T, Peroceschi R, Hassan-Abdi R, Groß M, Ellett F, Begon-Pescia C, Gonzalez C, Lutfalla G, Nguyen-Chi M
Citation:
Front Immunol. 2021;12:956. doi:10.3389/fimmu.2021.636585
Epub:
Not Epub
Abstract:
Immediately after a wound, macrophages are activated and change their phenotypes in reaction to danger signals released from...
Link:
https://www.frontiersin.org/articles/10.3389/fimmu.2021.636585/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sipka T, Peroceschi R, Hassan-Abdi R, Groß M, Ellett F, Begon-Pescia C, Gonzalez C, Lutfalla G, Nguyen-Chi M. Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish. Front Immunol. 2021;12:956. doi:10.3389/fimmu.2021.636585.

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

Authors:
Babolmorad G, Latif A, Domingo IK, Pollock NM, Delyea C, Rieger AM, Allison WT, Bhavsar AP
Citation:
EMBO Rep. 2021 Mar 18;e51280. doi: 10.15252/embr.202051280
Epub:
Not Epub
Abstract:
Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and can also be activated by some Group 9/10...
Link:
https://www.embopress.org/doi/full/10.15252/embr.202051280
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Babolmorad G, Latif A, Domingo IK, Pollock NM, Delyea C, Rieger AM, Allison WT, Bhavsar AP. Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity. EMBO Rep. 2021 Mar 18;e51280. doi: 10.15252/embr.202051280.

The SCF/KIT pathway implements self-organised epithelial patterning by cell movement

Authors:
Chuyen A, Rulquin C, Thome V, Clement R, Kodjabachian L, Pasini A
Citation:
Dev Cell. 2021;56(6):795-810. doi:10.1016/j.devcel.2021.02.026
Epub:
Not Epub
Abstract:
How global patterns emerge from individual cell behaviors is poorly understood. In the Xenopus embryonic epidermis,...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00166-0
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chuyen A, Rulquin C, Thome V, Clement R, Kodjabachian L, Pasini A. The SCF/KIT pathway implements self-organised epithelial patterning by cell movement. Dev Cell. 2021;56(6):795-810. doi:10.1016/j.devcel.2021.02.026.

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection

Authors:
Roy JCL, Vitalo A, Andrew MA, Mota-Silva E, Kovalenko M, Burch Z, Nhu AM, Cohen PE, Grabczyk E, Wheeler VC, Mouro Pinto R
Citation:
Nucleic Acids Res. 2021 Apr 19; 49(7): 3907–3918. doi:10.1093/nar/gkab152.
Epub:
Yes
Abstract:
Somatic expansion of the CAG repeat tract that causes Huntington's disease (HD) is thought to contribute to the rate of...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab152/6179926
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human primary fibroblasts, mice
Citation Extract:
Roy JCL, Vitalo A, Andrew MA, Mota-Silva E, Kovalenko M, Burch Z, Nhu AM, Cohen PE, Grabczyk E, Wheeler VC, Mouro Pinto R. Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection. Nucleic Acids Res. 2021 Apr 19; 49(7): 3907–3918. doi:10.1093/nar/gkab152..

Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development

Authors:
Guo S, Meng L, Liu H, Yuan L, Zhao N, Ni J, Zhang Y, Ben J, Li YP, Ma J
Citation:
Theranostics. 2021 Feb 25;11(9):4316-4334. doi: 10.7150/thno.51745. eCollection 2021
Epub:
Not Epub
Abstract:
Trio is a unique member of the Rho-GEF family that has three catalytic domains and is vital for various cellular processes in...
Link:
https://www.thno.org/v11p4316.htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guo S, Meng L, Liu H, Yuan L, Zhao N, Ni J, Zhang Y, Ben J, Li YP, Ma J. Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development. Theranostics. 2021 Feb 25;11(9):4316-4334. doi: 10.7150/thno.51745. eCollection 2021.

Furry is required for cell movements during gastrulation and functionally interacts with NDR1

Authors:
Cervino AS, Moretti B, Stuckenholz C, Grecco HE, Davidson LA, Cirio MC
Citation:
Sci Rep. 2021;11(1):6607. doi:10.1038/s41598-021-86153-x
Epub:
Not Epub
Abstract:
Gastrulation is a key event in animal embryogenesis during which germ layer precursors are rearranged and the embryonic axes...
Link:
https://www.nature.com/articles/s41598-021-86153-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Cervino AS, Moretti B, Stuckenholz C, Grecco HE, Davidson LA, Cirio MC. Furry is required for cell movements during gastrulation and functionally interacts with NDR1. Sci Rep. 2021;11(1):6607. doi:10.1038/s41598-021-86153-x.

Overexpressed Tumor Suppressor Exosomal miR-15a-5p in Cancer Cells Inhibits PD1 Expression in CD8+T Cells and Suppresses the Hepatocellular Carcinoma Progression

Authors:
Zhang H-Y, Liang H-X, Wu S-H, Jiang H-Q, Wang Q, Yu Z-J
Citation:
Front Oncol. 2021;11:440. doi:10.3389/fonc.2021.622263
Epub:
Not Epub
Abstract:
Background: Hepatocellular carcinoma (HCC) is the most common primary liver tumor, and the main reason is the unclear...
Link:
https://www.frontiersin.org/articles/10.3389/fonc.2021.622263/full
Delivery Method:
Lipofectamine 2000
Organism or Cell Type:
cell culture: HepG2
Citation Extract:
Zhang H-Y, Liang H-X, Wu S-H, Jiang H-Q, Wang Q, Yu Z-J. Overexpressed Tumor Suppressor Exosomal miR-15a-5p in Cancer Cells Inhibits PD1 Expression in CD8+T Cells and Suppresses the Hepatocellular Carcinoma Progression. Front Oncol. 2021;11:440. doi:10.3389/fonc.2021.622263.

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