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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12387 scientific papers returned from the database with the search filters currently being used below.

Identification of three novel FGF16 mutations in X-linked recessive fusion of the fourth and fifth metacarpals and possible correlation with heart disease

Authors:
Laurell T, Nilsson D, Hofmeister W, Lindstrand A, Ahituv N, Vandermeer J, Amilon A, Annerén G, Arner M, Pettersson M, Jäntti N, Rosberg H-E, Cattini PA, Nordenskjöld A, Mäkitie O, Grigelioniene G, Nordgren A.
Citation:
Mol Genet Genomic Med. 2014:[Epub ahead of print] doi:10.1002/mgg3.81
Epub:
Not Epub
Abstract:
Nonsense mutations in FGF16 have recently been linked to X-linked recessive hand malformations with fusion between the fourth...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Laurell T, Nilsson D, Hofmeister W, Lindstrand A, Ahituv N, Vandermeer J, Amilon A, Annerén G, Arner M, Pettersson M, Jäntti N, Rosberg H-E, Cattini PA, Nordenskjöld A, Mäkitie O, Grigelioniene G, Nordgren A.. Identification of three novel FGF16 mutations in X-linked recessive fusion of the fourth and fifth metacarpals and possible correlation with heart disease. Mol Genet Genomic Med. 2014:[Epub ahead of print] doi:10.1002/mgg3.81.

Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche

Authors:
Carroll KJ, Esain V, Garnaas MK, Cortes M, Dovey MC, Nissim S, Frechette GM, Liu SY, Kwan W, Cutting CC, Harris JM, Gorelick DA, Halpern ME, Lawson ND, Goessling W, North TE
Citation:
Dev Cell. 2014 May 27;29(4):437-53. doi: 10.1016/j.devcel.2014.04.012
Epub:
Not Epub
Abstract:
Genetic control of hematopoietic stem and progenitor cell (HSPC) function is increasingly understood; however, less is known...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Carroll KJ, Esain V, Garnaas MK, Cortes M, Dovey MC, Nissim S, Frechette GM, Liu SY, Kwan W, Cutting CC, Harris JM, Gorelick DA, Halpern ME, Lawson ND, Goessling W, North TE. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014 May 27;29(4):437-53. doi: 10.1016/j.devcel.2014.04.012.

Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery

Authors:
Panchal RG, Mourich DV, Bradfute S, Hauck LL, Warfield KL, Iversen PL, Bavari S
Citation:
Nucleic Acid Ther. 2014;24(3):179-185. doi:10.1089/nat.2013.0457
Epub:
Not Epub
Abstract:
Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Panchal RG, Mourich DV, Bradfute S, Hauck LL, Warfield KL, Iversen PL, Bavari S. Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery. Nucleic Acid Ther. 2014;24(3):179-185. doi:10.1089/nat.2013.0457.

Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response

Authors:
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A
Citation:
Immunity. 2014;[Epub ahead of print] doi:10.1016/j.immuni.2014.04.018
Epub:
Yes
Abstract:
Type I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity...
Delivery Method:
peptide-linked
Organism or Cell Type:
BALB/c mice
Citation Extract:
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response. Immunity. 2014;[Epub ahead of print] doi:10.1016/j.immuni.2014.04.018.

Maternal thyroid hormones are essential for neural development in zebrafish

Authors:
Campinho MA, Saraiva J, Florindo C, Power DM
Citation:
Mol Endocrinol. 2014 May 30:me20141032. [Epub ahead of print]
Epub:
Yes
Abstract:
Teleost eggs contain an abundant store of maternal thyroid hormones (THs) and early in zebrafish embryonic development all the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Campinho MA, Saraiva J, Florindo C, Power DM. Maternal thyroid hormones are essential for neural development in zebrafish. Mol Endocrinol. 2014 May 30:me20141032. [Epub ahead of print].

Retinoic acid induced-1 (Rai1) regulates craniofacial and brain development in Xenopus

Authors:
Tahir R, Kennedy A, Elsea SH, Dickinson AJ
Citation:
Mech Dev. 2014 May 27. pii: S0925-4773(14)00028-8. doi: 10.1016/j.mod.2014.05.004. [Epub ahead of print]
Epub:
Yes
Abstract:
Retinoic acid induced-1 (RAI1) is an important yet understudied histone code reader that when mutated in humans results in...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Tahir R, Kennedy A, Elsea SH, Dickinson AJ. Retinoic acid induced-1 (Rai1) regulates craniofacial and brain development in Xenopus. Mech Dev. 2014 May 27. pii: S0925-4773(14)00028-8. doi: 10.1016/j.mod.2014.05.004. [Epub ahead of print].

Hedgehog-PKA Signaling and gnrh3 Regulate the Development of Zebrafish gnrh3 Neurons

Authors:
Kuo M-W, Lou S-W, Chung B-c
Citation:
PLoS ONE. 2014;9(5):e95545. doi:10.1371/journal.pone.0095545
Epub:
Not Epub
Abstract:
GnRH neurons secrete GnRH that controls the development of the reproduction system. Despite many studies, the signals...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kuo M-W, Lou S-W, Chung B-c. Hedgehog-PKA Signaling and gnrh3 Regulate the Development of Zebrafish gnrh3 Neurons. PLoS ONE. 2014;9(5):e95545. doi:10.1371/journal.pone.0095545.

The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro

Authors:
Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A
Citation:
Development 2014 141:2216-2224; posted ahead of print May 12, 2014, doi:10.1242/dev.106377
Epub:
Not Epub
Abstract:
Generation of neurons from patient fibroblasts using a combination of developmentally defined transcription factors has great...
Organism or Cell Type:
Xenopus
Citation Extract:
Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development 2014 141:2216-2224; posted ahead of print May 12, 2014, doi:10.1242/dev.106377.

Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

Authors:
Howarth DL, Lindtner C, Vacaru AM, Sachidanandam R, Tsedensodnom O, Vasilkova T, Buettner C, Sadler KC
Citation:
PLoS Genet. 2014;10(5):e1004335
Epub:
Not Epub
Abstract:
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Howarth DL, Lindtner C, Vacaru AM, Sachidanandam R, Tsedensodnom O, Vasilkova T, Buettner C, Sadler KC. Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish. PLoS Genet. 2014;10(5):e1004335.

Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

Authors:
Ulmer Carnes M, Liu YP, Allingham RR, Whigham BT, Havens S, Garrett ME, Qiao C, NEIGHBORHOOD Consortium Investigators, Katsanis N, Wiggs JL, Pasquale LR, Ashley-Koch A, Oh EC, Hauser MA
Citation:
PLoS Genet. 2014;10(5):e1004372. doi:10.1371/journal.pgen.1004372
Epub:
Not Epub
Abstract:
Glaucoma is a leading cause of blindness worldwide. Primary open-angle glaucoma (POAG) is the most common subtype and is a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ulmer Carnes M, Liu YP, Allingham RR, Whigham BT, Havens S, Garrett ME, Qiao C, NEIGHBORHOOD Consortium Investigators, Katsanis N, Wiggs JL, Pasquale LR, Ashley-Koch A, Oh EC, Hauser MA. Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma. PLoS Genet. 2014;10(5):e1004372. doi:10.1371/journal.pgen.1004372.

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