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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos

Authors:
Lu J, Tsai T, Choo S, Yeh S, Tang R, Yang A, Lee H, Lu J
Citation:
J Biomed Sci. 2011;18:73 doi:10.1186/1423-0127-18-73
Epub:
Not Epub
Abstract:
Background The tbx5 mutation in human causes Holt-Oram syndrome, an autosomal dominant condition characterized by a familial...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu J, Tsai T, Choo S, Yeh S, Tang R, Yang A, Lee H, Lu J. Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos. J Biomed Sci. 2011;18:73 doi:10.1186/1423-0127-18-73.

Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy.

Authors:
Lorent K, Yeo SY, Oda T, Chandrasekharappa S, Chitnis A, Matthews RP, Pack M.
Citation:
Development. 2004 Nov;131(22):5753-66.
Epub:
Not Epub
Abstract:
The Alagille Syndrome (AGS) is a heritable disorder affecting the liver and other organs. Causative dominant mutations in human...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lorent K, Yeo SY, Oda T, Chandrasekharappa S, Chitnis A, Matthews RP, Pack M.. Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy.. Development. 2004 Nov;131(22):5753-66..

Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein

Authors:
Liu KJ, Harland RM
Citation:
Development. 2005 Apr;132(7):1511-23. Epub 2005 Feb 23
Epub:
Not Epub
Abstract:
Although serine-arginine rich (SR) proteins have often been implicated in the positive regulation of splicing, recent studies...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Liu KJ, Harland RM. Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein. Development. 2005 Apr;132(7):1511-23. Epub 2005 Feb 23.

K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis

Authors:
Liu L, Zhu S, Gong Z, Low BC
Citation:
PLoS ONE. 2008 Aug 6;3(8):e2850
Epub:
Not Epub
Abstract:
The RAS small GTPases orchestrate multiple cellular processes. Studies on knock-out mice showed the essential and sufficient...
Organism or Cell Type:
zebrafish
Citation Extract:
Liu L, Zhu S, Gong Z, Low BC. K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis. PLoS ONE. 2008 Aug 6;3(8):e2850.

Kinetic Mechanisms in Morpholino-DNA Surface Hybridization

Authors:
Liu Y, Irving D, Qiao W, Ge D, Levicky R
Citation:
J. Am. Chem. Soc. 2011;[Epub ahead of print] DOI: 10.1021/ja202631b
Epub:
Not Epub
Abstract:
Morpholinos (MOs) are DNA analogues whose uncharged nature can bring fundamental advantages to surface hybridization...
Delivery Method:
species. Advancement of MO-based diagnostics
Organism or Cell Type:
however
Citation Extract:
Liu Y, Irving D, Qiao W, Ge D, Levicky R. Kinetic Mechanisms in Morpholino-DNA Surface Hybridization. J. Am. Chem. Soc. 2011;[Epub ahead of print] DOI: 10.1021/ja202631b.

Knockdown of Leptin A Expression Dramatically Alters Zebrafish Development

Authors:
Liu Q, Dalman M, Chen Y, Akhter M, Brahmandam S, Patel Y, Lowe J, Thakkar M, Gregory AV, Phelps D, Riley C, Londraville RL
Citation:
Gen Comp Endocrinol. 2012;[Epub ahead of print] doi:10.1016/j.ygcen.2012.07.011
Epub:
Not Epub
Abstract:
Using morpholino antisense oligonucleotide (MO) technology, we blocked leptin A or leptin receptor expression in embryonic...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu Q, Dalman M, Chen Y, Akhter M, Brahmandam S, Patel Y, Lowe J, Thakkar M, Gregory AV, Phelps D, Riley C, Londraville RL. Knockdown of Leptin A Expression Dramatically Alters Zebrafish Development. Gen Comp Endocrinol. 2012;[Epub ahead of print] doi:10.1016/j.ygcen.2012.07.011.

Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.

Authors:
Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT
Citation:
Dev Cell. 2003 Dec;5(6):903-14
Epub:
Not Epub
Abstract:
Mechanisms underlying the multiple developmental defects observed in Fanconi anemia (FA) patients are not well defined. We have...
Delivery Method:
microinjection in embryos, Special Delivery in culture
Organism or Cell Type:
Zebrafish embryos and cultured zebrafish fibroblast AB9 cells
Citation Extract:
Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.. Dev Cell. 2003 Dec;5(6):903-14.

Leukocyte tyrosine kinase functions in pigment cell development

Authors:
Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, Delfino-Machín M, Haffter P, Geisler R, Johnson SL, Ward A, Kelsh RN
Citation:
PLoS Genet. 2008 Mar 7;4(3):e1000026
Epub:
Not Epub
Abstract:
A fundamental problem in developmental biology concerns how multipotent precursors choose specific fates. Neural crest cells (...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ, Jacoby AS, Hurst LD, Delfino-Machín M, Haffter P, Geisler R, Johnson SL, Ward A, Kelsh RN. Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genet. 2008 Mar 7;4(3):e1000026.

Lysophosphatidic acid signaling controls cortical actin assembly and cytoarchitecture in Xenopus embryos

Authors:
Lloyd B, Tao Q, Lang S, Wylie C
Citation:
Development. 2005 Feb;132(4):805-16. Epub 2005 Jan 19
Epub:
Not Epub
Abstract:
The mechanisms that control shape and rigidity of early embryos are not well understood, and yet are required for all embryonic...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Lloyd B, Tao Q, Lang S, Wylie C. Lysophosphatidic acid signaling controls cortical actin assembly and cytoarchitecture in Xenopus embryos. Development. 2005 Feb;132(4):805-16. Epub 2005 Jan 19.

MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating JNK2 phosphorylation

Authors:
Liu X, Ning G, Meng A, Wang Q
Citation:
Mol Cell Biol. 2012 May 21. [Epub ahead of print]
Epub:
Not Epub
Abstract:
During vertebrate gastrulation, both concurrent inductive events and cell movements are required for axis formation....
Organism or Cell Type:
zebrafish
Citation Extract:
Liu X, Ning G, Meng A, Wang Q. MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating JNK2 phosphorylation. Mol Cell Biol. 2012 May 21. [Epub ahead of print].

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