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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Leveraging gene therapy to achieve long-term continuous or controllable expression of biotherapeutics

Authors:
Cripe TP, Hutzen B, Currier MA, Chen CY, Glaspell AM, Sullivan GC, Hurley JM, Deighen MR, Venkataramany AS, Mo X, Stanek JR, Miller AR, Wijeratne S, Magrini V, Mardis ER, Mendell JR, Chandler DS, Wang PY
Citation:
Sci Adv. 2022 Jul 15;8(28):eabm1890. doi: 10.1126/sciadv.abm1890. Epub 2022 Jul 13
Epub:
Not Epub
Abstract:
T cells redirected to cancer cells either via a chimeric antigen receptor (CAR-T) or a bispecific molecule have been...
Link:
https://www.science.org/doi/10.1126/sciadv.abm1890
Delivery Method:
Endo-Porter, Vivo-Morpholino
Organism or Cell Type:
cell culture 293T, mice non-obese diabetic scid gamma NSG-SGM3
Citation Extract:
Cripe TP, Hutzen B, Currier MA, Chen CY, Glaspell AM, Sullivan GC, Hurley JM, Deighen MR, Venkataramany AS, Mo X, Stanek JR, Miller AR, Wijeratne S, Magrini V, Mardis ER, Mendell JR, Chandler DS, Wang PY. Leveraging gene therapy to achieve long-term continuous or controllable expression of biotherapeutics. Sci Adv. 2022 Jul 15;8(28):eabm1890. doi: 10.1126/sciadv.abm1890. Epub 2022 Jul 13.

Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice

Authors:
Desjardins CA, Yao M, Hall J, O'Donnell E, Venkatesan R, Spring S, Wen A, Hsia N, Shen P, Russo R, Lan B, Picariello T, Tang K, Weeden T, Zanotti S, Subramanian R, Ibraghimov-Beskrovnaya O
Citation:
Nucleic Acids Res. 2022 Aug 10:gkac641. doi: 10.1093/nar/gkac641. Online ahead of print
Epub:
Yes
Abstract:
Current therapies for Duchenne muscular dystrophy (DMD) use phosphorodiamidate morpholino oligomers (PMO) to induce exon...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac641/6656072
Delivery Method:
FORCE antigen-binding conjugate
Organism or Cell Type:
mice
Citation Extract:
Desjardins CA, Yao M, Hall J, O'Donnell E, Venkatesan R, Spring S, Wen A, Hsia N, Shen P, Russo R, Lan B, Picariello T, Tang K, Weeden T, Zanotti S, Subramanian R, Ibraghimov-Beskrovnaya O. Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice. Nucleic Acids Res. 2022 Aug 10:gkac641. doi: 10.1093/nar/gkac641. Online ahead of print.

AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy.

Authors:
Das O, Kundu J, Ghosh A, Gautam A, Ghosh S, Chakraborty M, Masid A, Gauri SS, Mitra D, Dutta M, Mukherjee B, Sinha S, Bhaumik M
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.13.496022
Epub:
Not Epub
Abstract:
This discourse probes the mechanistic molecular details of butyrate action in maintaining host-cholesterol balance. Hepatic...
Link:
https://www.biorxiv.org/content/10.1101/2022.06.13.496022v1
Delivery Method:
guanidinium-Morpholino GMO-PMO
Organism or Cell Type:
mice
Citation Extract:
Das O, Kundu J, Ghosh A, Gautam A, Ghosh S, Chakraborty M, Masid A, Gauri SS, Mitra D, Dutta M, Mukherjee B, Sinha S, Bhaumik M. AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy. . bioRxiv. 2022;[preprint] doi:10.1101/2022.06.13.496022 .

CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1

Authors:
Zhang MX, Wang JL, Mo CQ, Mao XP, Feng ZH, Li JY, Lin HS, Song HD, Xu QH, Wang YH, Lu J, Wei JH, Han H, Chen W, Mao HP, Luo JH, Chen ZH
Citation:
Oncogene. 2022 Jul 7. doi: 10.1038/s41388-022-02386-8. Online ahead of print
Epub:
Not Epub
Abstract:
Circular RNAs (circRNAs) play critical roles in clear cell renal cell carcinoma (ccRCC). However, their involvement in...
Link:
https://www.nature.com/articles/s41388-022-02386-8
Delivery Method:
electroporation
Organism or Cell Type:
cell culture
Citation Extract:
Zhang MX, Wang JL, Mo CQ, Mao XP, Feng ZH, Li JY, Lin HS, Song HD, Xu QH, Wang YH, Lu J, Wei JH, Han H, Chen W, Mao HP, Luo JH, Chen ZH. CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1. Oncogene. 2022 Jul 7. doi: 10.1038/s41388-022-02386-8. Online ahead of print.

Long-Term Systemic Treatment of a Mouse Model Displaying Chronic FSHD-like Pathology with Antisense Therapeutics That Inhibit DUX4 Expression

Authors:
Lu-Nguyen N, Dickson G, Malerba A, Popplewell L
Citation:
Biomedicines. 2022 Jul 7;10(7):1623. doi: 10.3390/biomedicines10071623
Epub:
Not Epub
Abstract:
Silencing the expression of the double homeobox 4 (DUX4) gene offers great potential for the treatment of facioscapulohumeral...
Link:
https://www.mdpi.com/2227-9059/10/7/1623/htm
Delivery Method:
Vivo-Morpholino i.p. injection
Organism or Cell Type:
mice
Citation Extract:
Lu-Nguyen N, Dickson G, Malerba A, Popplewell L. Long-Term Systemic Treatment of a Mouse Model Displaying Chronic FSHD-like Pathology with Antisense Therapeutics That Inhibit DUX4 Expression. Biomedicines. 2022 Jul 7;10(7):1623. doi: 10.3390/biomedicines10071623.

Irf2bp2a regulates liver development via stabilizing P53 protein in zebrafish

Authors:
Yan L, Gao S, Zhu J, Zhou J
Citation:
Biochim Biophys Acta Gen Subj. 2022 Oct;1866(10):130186. doi: 10.1016/j.bbagen.2022.130186. Epub 2022 Jun 7
Epub:
Not Epub
Abstract:
Zebrafish irf2bp2a, an ortholog of human IRF2BP2, is specifically expressed in the developing liver at growth stage. As a multi...
Link:
https://www.sciencedirect.com/science/article/pii/S0304416522001040
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yan L, Gao S, Zhu J, Zhou J. Irf2bp2a regulates liver development via stabilizing P53 protein in zebrafish. Biochim Biophys Acta Gen Subj. 2022 Oct;1866(10):130186. doi: 10.1016/j.bbagen.2022.130186. Epub 2022 Jun 7.

Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

Authors:
Babu S, Takeuchi Y, Masai I
Citation:
Elife. 2022 Aug 9;11:e74611. doi: 10.7554/eLife.74611
Epub:
Not Epub
Abstract:
Btg3-associated nuclear protein (Banp) was originally identified as a nuclear matrix-associated region (MAR)-binding protein...
Link:
https://elifesciences.org/articles/74611
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Babu S, Takeuchi Y, Masai I. Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. Elife. 2022 Aug 9;11:e74611. doi: 10.7554/eLife.74611.

Ankle2 deficiency-associated microcephaly and spermatogenesis defects in zebrafish are alleviated by heterozygous deletion of vrk1

Authors:
Apridita Sebastian W, Shiraishi H, Shimizu N, Umeda R, Lai S, Ikeuchi M, Morisaki I, Yano S, Yoshimura A, Hanada R, Hanada T
Citation:
Biochem Biophys Res Commun. 2022 Oct 8;624:95-101. doi: 10.1016/j.bbrc.2022.07.070. Epub 2022 Jul 31. PMID: 35940133
Epub:
Not Epub
Abstract:
Autosomal recessive primary microcephaly (MCPH) is a rare congenital disorder characterized by a below average brain volume at...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X22010476
Organism or Cell Type:
zebrafish
Citation Extract:
Apridita Sebastian W, Shiraishi H, Shimizu N, Umeda R, Lai S, Ikeuchi M, Morisaki I, Yano S, Yoshimura A, Hanada R, Hanada T. Ankle2 deficiency-associated microcephaly and spermatogenesis defects in zebrafish are alleviated by heterozygous deletion of vrk1. Biochem Biophys Res Commun. 2022 Oct 8;624:95-101. doi: 10.1016/j.bbrc.2022.07.070. Epub 2022 Jul 31. PMID: 35940133.

Sox11b regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish

Authors:
Song K, Lin Z, Cao L, Lu B, Chen Y, Zhang S, Lu J, Xu H
Citation:
Neural Regen Res. 2023 Feb;18(2):445-450. doi: 10.4103/1673-5374.346550
Epub:
Not Epub
Abstract:
The transcription factor Sox11 plays important roles in retinal neurogenesis during vertebrate eye development. However, its...
Link:
https://journals.lww.com/nrronline/Fulltext/2023/02000/Sox11b_regulates_the_migration_and_fate.49.aspx
Delivery Method:
electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Song K, Lin Z, Cao L, Lu B, Chen Y, Zhang S, Lu J, Xu H. Sox11b regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish. Neural Regen Res. 2023 Feb;18(2):445-450. doi: 10.4103/1673-5374.346550.

Quantification of Idua Enzymatic Activity Combined with Observation of Phenotypic Change in Zebrafish Embryos Provide a Preliminary Assessment of Mutated idua Correlated with Mucopolysaccharidosis Type I

Authors:
Lin CY, Lin HY, Chuang CK, Zhang PH, Tu YR, Lin SP, Tsai HJ
Citation:
J Pers Med. 2022 Jul 23;12(8):1199. doi: 10.3390/jpm12081199
Epub:
Not Epub
Abstract:
Mucopolysaccharidosis type I (MPS I) is an inherited autosomal recessive disease resulting from mutation of the α-l-Iduronidase...
Link:
https://www.mdpi.com/2075-4426/12/8/1199/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin CY, Lin HY, Chuang CK, Zhang PH, Tu YR, Lin SP, Tsai HJ. Quantification of Idua Enzymatic Activity Combined with Observation of Phenotypic Change in Zebrafish Embryos Provide a Preliminary Assessment of Mutated idua Correlated with Mucopolysaccharidosis Type I. J Pers Med. 2022 Jul 23;12(8):1199. doi: 10.3390/jpm12081199.

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