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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators

Authors:
Liu YP, Tsai I-C, Morleo M, Oh EC, Leitch CC, Massa F, Lee B-H, Parker DS, Finley D, Zaghloul NA, Franco B, Katsanis NK
Citation:
J Clin Invest. 2014;[Epub ahead of print] doi:10.1172/JCI71898
Epub:
Not Epub
Abstract:
Cilia are critical mediators of paracrine signaling; however, it is unknown whether proteins that contribute to ciliopathies...
Link:
http://www.jci.org/articles/view/71898
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu YP, Tsai I-C, Morleo M, Oh EC, Leitch CC, Massa F, Lee B-H, Parker DS, Finley D, Zaghloul NA, Franco B, Katsanis NK. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J Clin Invest. 2014;[Epub ahead of print] doi:10.1172/JCI71898.

Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations

Authors:
Russell MR, Raeker MO, Geisler SB, Thomas PE, Simmons TA, Bernat JA, Thorsson T, Innis JW
Citation:
Hum Mol Genet. 2014;[Epub ahead of print] doi:10.1093/hmg/ddu144
Epub:
Yes
Abstract:
Recurrent 2q13 deletion syndrome is associated with incompletely penetrant severe cardiac defects and craniofacial anomalies....
Link:
http://hmg.oxfordjournals.org/content/early/2014/04/02/hmg.ddu144.abstract
Organism or Cell Type:
zebrafish
Citation Extract:
Russell MR, Raeker MO, Geisler SB, Thomas PE, Simmons TA, Bernat JA, Thorsson T, Innis JW. Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations. Hum Mol Genet. 2014;[Epub ahead of print] doi:10.1093/hmg/ddu144.

A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of Xenopus tadpoles

Authors:
Walentek P, Bogusch S, Thumberger T, Vick P, Dubaissi E, Beyer T, Blum M, Schweickert A
Citation:
Development. 2014 Apr;141(7):1526-33. doi: 10.1242/dev.102343. Epub 2014 Mar 5
Epub:
Not Epub
Abstract:
The embryonic skin of Xenopus tadpoles serves as an experimental model system for mucociliary epithelia (MCE) such as the human...
Link:
http://dev.biologists.org/content/141/7/1526.abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Walentek P, Bogusch S, Thumberger T, Vick P, Dubaissi E, Beyer T, Blum M, Schweickert A. A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of Xenopus tadpoles. Development. 2014 Apr;141(7):1526-33. doi: 10.1242/dev.102343. Epub 2014 Mar 5.

Heparanase 2, mutated in urofacial syndrome, mediates peripheral neural development in Xenopus

Authors:
Roberts NA, Woolf AS, Stuart HM, Thuret R, McKenzie EA, Newman WG, Hilton EN
Citation:
Hum Mol Genet. 2014;[Epub ahead of print] doi:10.1093/hmg/ddu147
Epub:
Yes
Abstract:
Urofacial syndrome (UFS; previously Ochoa syndrome) is an autosomal recessive disease characterised by incomplete bladder...
Link:
http://hmg.oxfordjournals.org/content/early/2014/04/01/hmg.ddu147.abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Roberts NA, Woolf AS, Stuart HM, Thuret R, McKenzie EA, Newman WG, Hilton EN. Heparanase 2, mutated in urofacial syndrome, mediates peripheral neural development in Xenopus. Hum Mol Genet. 2014;[Epub ahead of print] doi:10.1093/hmg/ddu147.

Antisense Oligonucleotide-Based Therapy in Human Erythropoietic Protoporphyria

Authors:
Oustric V, Manceau H, Ducamp S, Soaid R, Karim Z, Schmitt C, Mirmiran A, Peoc'h K, Grandchamp B, Beaumont C, Lyoumi S, Moreau-Gaudry F, Guyonnet-Dupérat V, de Verneuil H, Marie J, Puy H, Deybach JC, Gouya L
Citation:
Am J Hum Genet. 2014 Mar 26. pii: S0002-9297(14)00068-8. doi: 10.1016/j.ajhg.2014.02.010. [Epub ahead of print]
Epub:
Not Epub
Abstract:
In 90% of people with erythropoietic protoporphyria (EPP), the disease results from the inheritance of a common hypomorphic...
Link:
http://www.cell.com/AJHG/abstract/S0002-9297%2814%2900068-8
Organism or Cell Type:
cell culture
Citation Extract:
Oustric V, Manceau H, Ducamp S, Soaid R, Karim Z, Schmitt C, Mirmiran A, Peoc'h K, Grandchamp B, Beaumont C, Lyoumi S, Moreau-Gaudry F, Guyonnet-Dupérat V, de Verneuil H, Marie J, Puy H, Deybach JC, Gouya L. Antisense Oligonucleotide-Based Therapy in Human Erythropoietic Protoporphyria. Am J Hum Genet. 2014 Mar 26. pii: S0002-9297(14)00068-8. doi: 10.1016/j.ajhg.2014.02.010. [Epub ahead of print].

IRE1α is essential for Xenopus pancreas development

Authors:
Yuan L, Li X, Feng J, Yin C, Yuan F, Wang X
Citation:
J Biomed Res. 2014 Mar;28(2):123-31. doi: 10.7555/JBR.28.20130076. Epub 2013 Dec 25
Epub:
Not Epub
Abstract:
Inositol requiring enzyme-1 (IRE1) is highly conserved from yeasts to humans. Upon the endoplasmic reticulum (ER) stress, IRE1...
Link:
http://www.jbr-pub.org/ch/reader/view_abstract.aspx?file_no=JBR140208
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Yuan L, Li X, Feng J, Yin C, Yuan F, Wang X. IRE1α is essential for Xenopus pancreas development. J Biomed Res. 2014 Mar;28(2):123-31. doi: 10.7555/JBR.28.20130076. Epub 2013 Dec 25.

3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells

Authors:
Davidson L, Muniz L, West S
Citation:
Genes Dev. 2014 Feb 15;28(4):342-56. doi: 10.1101/gad.231274.113. Epub 2014 Jan 29
Epub:
Yes
Abstract:
3' end formation of pre-mRNAs is coupled to their transcription via the C-terminal domain (CTD) of RNA polymerase II (Pol...
Link:
http://genesdev.cshlp.org/content/28/4/342.long
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Davidson L, Muniz L, West S. 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. Genes Dev. 2014 Feb 15;28(4):342-56. doi: 10.1101/gad.231274.113. Epub 2014 Jan 29.

Angiopoietin-like 3 regulates hepatocyte proliferation and lipid metabolism in zebrafish

Authors:
Lee S-H, So J-H, Kim H-T, Choi J-W, Lee M-S, Choi S-Y, Kim C-H, Kim MJ
Citation:
Biochem Biophys Res Comm. 2014;[Epub ahead of print] doi:10.1016/j.bbrc.2014.03.099
Epub:
Yes
Abstract:
Loss-of-function mutations in angiopoietin-like 3 (ANGPTL3) cause familial hypobetalipoproteinemia type 2 (FHBL2) in humans....
Link:
http://www.sciencedirect.com/science/article/pii/S0006291X14005518
Organism or Cell Type:
zebrafish
Citation Extract:
Lee S-H, So J-H, Kim H-T, Choi J-W, Lee M-S, Choi S-Y, Kim C-H, Kim MJ. Angiopoietin-like 3 regulates hepatocyte proliferation and lipid metabolism in zebrafish. Biochem Biophys Res Comm. 2014;[Epub ahead of print] doi:10.1016/j.bbrc.2014.03.099.

A Zebrafish Chemical Suppressor Screening Identifies Small Molecule Inhibitors of the Wnt/β-catenin Pathway

Authors:
Nishiya N, Oku Y, Kumagai Y, Sato Y, Yamaguchi E, Sasaki A, Shoji M, Ohnishi Y, Okamoto H, Uehara Y
Citation:
Chem & Biol. 2014;[Epub ahead of print] doi:10.1016/j.chembiol.2014.02.015
Epub:
Not Epub
Abstract:
Genetic screening for suppressor mutants has been successfully used to identify important signaling regulators. Using an...
Link:
http://www.cell.chttp://www.cell.com/chemistry-biology/abstract/S1074-5521%2814%2900074-Xom/chemistry-biology/abstract/S1074-5521%2814%2900074-X
Organism or Cell Type:
zebrafish
Citation Extract:
Nishiya N, Oku Y, Kumagai Y, Sato Y, Yamaguchi E, Sasaki A, Shoji M, Ohnishi Y, Okamoto H, Uehara Y. A Zebrafish Chemical Suppressor Screening Identifies Small Molecule Inhibitors of the Wnt/β-catenin Pathway. Chem & Biol. 2014;[Epub ahead of print] doi:10.1016/j.chembiol.2014.02.015.

SLC7A14 linked to autosomal recessive retinitis pigmentosa

Authors:
Jin ZB, Huang XF, Lv JN, Xiang L, Li DQ, Chen J, Huang C, Wu J, Lu F, Qu J
Citation:
Nat Commun. 2014 Mar 27;5:3517. doi: 10.1038/ncomms4517
Epub:
Not Epub
Abstract:
Retinitis pigmentosa (RP) is characterized by degeneration of the retinal photoreceptors and is the leading cause of inherited...
Link:
http://www.nature.com/ncomms/2014/140327/ncomms4517/full/ncomms4517.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jin ZB, Huang XF, Lv JN, Xiang L, Li DQ, Chen J, Huang C, Wu J, Lu F, Qu J. SLC7A14 linked to autosomal recessive retinitis pigmentosa. Nat Commun. 2014 Mar 27;5:3517. doi: 10.1038/ncomms4517.

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