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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
CRISPR/Cas9 targeting Ttc30a mimics ciliary chondrodysplasia with polycystic kidney disease
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.27.400994 Epub:
Not Epub Abstract:
Skeletal ciliopathies (e.g. Jeune syndrome, short rib polydactyly syndrome, Sensenbrenner syndrome) are frequently associated... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Getwan M, Hoppmann A, Schlosser P, Grand K, Song W, Diehl R, Schroda S, Heeg F, Deutsch K, Hildebrandt F, Lausch E, Köttgen A, Lienkamp SS. CRISPR/Cas9 targeting Ttc30a mimics ciliary chondrodysplasia with polycystic kidney disease. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.27.400994 . |
Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.23.394171 Epub:
Not Epub Abstract:
Zygotic genome activation (ZGA) initiates regionalized transcription responsible for the acquisition of distinct cellular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Pradhan SJ, Reddy PC, Smutny M, Sharma A, Sako K, Oak MS, Shah R, Pal M, Deshpande O, Tang Y, Mishra R, Deshpande G, Giraldez AJ, Sonawane M, Heisenberg C-P, Galande S. Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.23.394171 . |
Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation
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Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.02.11.944033 Epub:
Not Epub Abstract:
Morphogenesis is governed by the interplay of molecular signals and mechanical forces across multiple length scales. The last... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Huebner RJ, Malmi-Kakkada AN, Sarikaya S, Weng S, Thirumalai D, Wallingford JB. Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation. bioRxiv. 2020;[preprint] doi:10.1101/2020.02.11.944033. |
In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces
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Citation:
Fluids Barriers CNS. 2020;17(1):72. doi:10.1186/s12987-020-00234-z Epub:
Not Epub Abstract:
Hydrocephalus, the pathological expansion of the cerebrospinal fluid (CSF)-filled cerebral ventricles, is a common, deadly... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Dur AH, Tang T, Viviano S, Sekuri A, Willsey HR, Tagare HD, Kahle KT, Deniz E. In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces. Fluids Barriers CNS. 2020;17(1):72. doi:10.1186/s12987-020-00234-z. |
Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis
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Citation:
Thromb Haemost. 2020 Dec 10. doi: 10.1055/s-0040-1718414. Online ahead of print Epub:
Yes Abstract:
Thrombosis is a leading cause of morbidity and mortality. Fibrinogen, the soluble substrate for fibrin-based clotting, has a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Vilar R, Lukowski SW, Garieri M, Di Sanza C, Neerman-Arbez M, Fish RJ. Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis. Thromb Haemost. 2020 Dec 10. doi: 10.1055/s-0040-1718414. Online ahead of print. |
PMO-based let-7c site blocking oligonucleotide (SBO) mediated utrophin upregulation in mdx mice, a therapeutic approach for Duchenne muscular dystrophy (DMD)
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Citation:
Sci Rep. 2020;10(1):21492. doi:10.1038/s41598-020-76338-1 Epub:
Not Epub Abstract:
Upregulation of utrophin, a dystrophin related protein, is considered a promising therapeutic approach for Duchenne muscular... Delivery Method:
injection Organism or Cell Type:
mice (mdx) Citation Extract: Sengupta K, Loro E, Khurana TS. PMO-based let-7c site blocking oligonucleotide (SBO) mediated utrophin upregulation in mdx mice, a therapeutic approach for Duchenne muscular dystrophy (DMD). Sci Rep. 2020;10(1):21492. doi:10.1038/s41598-020-76338-1. |
Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo
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Citation:
Development. 2021;148: dev189944 [Epub ahead of print] doi:10.1242/dev.189944 Epub:
Yes Abstract:
During sea urchin development, secretion of Nodal and BMP2/4 ligands and their antagonists Lefty and Chordin from a ventral... Delivery Method:
microinjection Organism or Cell Type:
Paracentrotus lividus (sea urchin) Citation Extract: Floc'hlay S, Jimenez MDM, Hernandez C, Haillot E, Thomas-Chollier M, Lepage T, Thieffry D. Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo. Development. 2021;148: dev189944 [Epub ahead of print] doi:10.1242/dev.189944. |
Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway
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Citation:
Sci Rep. 2020;10(1):21555 doi:10.1038/s41598-020-78019-5 Epub:
Not Epub Abstract:
The canonical Wnt pathway serves as a hub connecting diverse cellular processes, including β-catenin signaling, differentiation... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Colozza G, Jami-Alahmadi Y, Dsouza A, Tejeda-Munoz N, Albrecht LV, Sosa E, Wohlschlegel JA, De Robertis EM. Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway. Sci Rep. 2020;10(1):21555 doi:10.1038/s41598-020-78019-5. |
Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos
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Citation:
microPublication Biology. 2020; doi:10.17912/micropub.biology.000341 Epub:
Not Epub Abstract:
no abstract available
Figure 1. Morpholino (MO) knockdown of foxk1/foxk2a/foxk2b and transcriptional profiling of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Geng F-S, de la Calle-Mustienes E, Gómez-Skarmeta JL, Lister R, Bogdanovic O. Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos. microPublication Biology. 2020; doi:10.17912/micropub.biology.000341. |
Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b
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Citation:
Dev Biol. 2020 Dec 5:S0012-1606(20)30310-9. doi: 10.1016/j.ydbio.2020.12.001. Online ahead of print Epub:
Yes Abstract:
During vertebrate embryonic development complex morphogenetic events drive the formation of internal organs associated with the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Dalgin G, Prince VE. Midline morphogenesis of zebrafish foregut endoderm is dependent on Hoxb5b. Dev Biol. 2020 Dec 5:S0012-1606(20)30310-9. doi: 10.1016/j.ydbio.2020.12.001. Online ahead of print. |