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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12511 scientific papers returned from the database with the search filters currently being used below.

PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

Authors:
Haas M, Cherfa S, Nguyen L, Bourgoin M, Caron G, Dessauge E, Marchand T, Delpy L, Auberger P, Moreaux J, Jacquel A, Fest T
Citation:
Nat Commun. 2025 Jan 2;16(1):256. doi: 10.1038/s41467-024-55572-5. PMID: 39747141; PMCID: PMC11696207
Epub:
Not Epub
Abstract:
Our study explores the complex dynamics of the integrated stress response (ISR) axis, highlighting PIM2 kinase's critical...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11696207/
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Human peripheral blood primary B cells; multiple myeloma cell lines engrafted into NSG mice
Citation Extract:
Haas M, Cherfa S, Nguyen L, Bourgoin M, Caron G, Dessauge E, Marchand T, Delpy L, Auberger P, Moreaux J, Jacquel A, Fest T. PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression. Nat Commun. 2025 Jan 2;16(1):256. doi: 10.1038/s41467-024-55572-5. PMID: 39747141; PMCID: PMC11696207.

NaP-TRAP reveals the regulatory grammar in 5'UTR-mediated translation regulation during zebrafish development

Authors:
Strayer EC, Krishna S, Lee H, Vejnar C, Neuenkirchen N, Gupta A, Beaudoin JD, Giraldez AJ
Citation:
Nat Commun. 2024 Dec 30;15(1):10898. doi: 10.1038/s41467-024-55274-y. PMID: 39738051; PMCID: PMC11685710
Epub:
Not Epub
Abstract:
The cis-regulatory elements encoded in an mRNA determine its stability and translational output. While there has been a...
Link:
https://www.nature.com/articles/s41467-024-55274-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Strayer EC, Krishna S, Lee H, Vejnar C, Neuenkirchen N, Gupta A, Beaudoin JD, Giraldez AJ. NaP-TRAP reveals the regulatory grammar in 5'UTR-mediated translation regulation during zebrafish development. Nat Commun. 2024 Dec 30;15(1):10898. doi: 10.1038/s41467-024-55274-y. PMID: 39738051; PMCID: PMC11685710.

A Microtubule-Associated Protein Functions in Preventing Oocytes from Evading the Spindle Assembly Checkpoint

Authors:
Zhou C, Zhang X, Xu G, Ran Y, Wang H, Xie X, Li A, Li F, Li X, Ding J, Zhang M, Sun QY, Ou XH
Citation:
Adv Sci (Weinh). 2024 Dec 25:e2413097. doi: 10.1002/advs.202413097. Epub ahead of print. PMID: 39721007
Epub:
Not Epub
Abstract:
Aneuploidy eggs are a common cause of human infertility, spontaneous abortion, or trisomy syndromes. The spindle assembly...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202413097
Delivery Method:
microinjection
Organism or Cell Type:
ICR mouse oocysts
Citation Extract:
Zhou C, Zhang X, Xu G, Ran Y, Wang H, Xie X, Li A, Li F, Li X, Ding J, Zhang M, Sun QY, Ou XH. A Microtubule-Associated Protein Functions in Preventing Oocytes from Evading the Spindle Assembly Checkpoint. Adv Sci (Weinh). 2024 Dec 25:e2413097. doi: 10.1002/advs.202413097. Epub ahead of print. PMID: 39721007.

Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development

Authors:
Matsumoto K, Akieda Y, Haraoka Y, Hirono N, Sasaki H, Ishitani T
Citation:
Nat Commun. 2024 Dec 17;15(1):10662. doi: 10.1038/s41467-024-55108-x. PMID: 39690179; PMCID: PMC11652645
Epub:
Not Epub
Abstract:
Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However,...
Link:
https://www.nature.com/articles/s41467-024-55108-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Matsumoto K, Akieda Y, Haraoka Y, Hirono N, Sasaki H, Ishitani T. Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nat Commun. 2024 Dec 17;15(1):10662. doi: 10.1038/s41467-024-55108-x. PMID: 39690179; PMCID: PMC11652645.

SINEUP RNA rescues molecular phenotypes associated with CHD8 suppression in autism spectrum disorder model systems

Authors:
Di Leva F, Arnoldi M, Santarelli S, Massonot M, Lemée MV, Bon C, Pellegrini M, Castellini ME, Zarantonello G, Messina A, Bozzi Y, Bernier R, Zucchelli S, Casarosa S, Dassi E, Ronzitti G, Golzio C, Morandell J, Gustincich S, Espinoza S, Biagioli M
Citation:
Mol Ther. 2025 Mar 5;33(3):1180-1196. doi: 10.1016/j.ymthe.2024.12.043. Epub 2024 Dec 30. PMID: 39741407
Epub:
Not Epub
Abstract:
Loss-of-function mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are strongly associated with autism spectrum...
Link:
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(24)00843-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Di Leva F, Arnoldi M, Santarelli S, Massonot M, Lemée MV, Bon C, Pellegrini M, Castellini ME, Zarantonello G, Messina A, Bozzi Y, Bernier R, Zucchelli S, Casarosa S, Dassi E, Ronzitti G, Golzio C, Morandell J, Gustincich S, Espinoza S, Biagioli M. SINEUP RNA rescues molecular phenotypes associated with CHD8 suppression in autism spectrum disorder model systems. Mol Ther. 2025 Mar 5;33(3):1180-1196. doi: 10.1016/j.ymthe.2024.12.043. Epub 2024 Dec 30. PMID: 39741407.

A chitin-binding domain-containing gene is essential for shell development in the mollusc Tritia

Authors:
Dao TK, Ferger K, Lambert JD
Citation:
Dev Biol. 2025 Apr;520:1-12. doi: 10.1016/j.ydbio.2024.12.016. Epub 2024 Dec 24. PMID: 39725261
Epub:
Not Epub
Abstract:
Mollusc shells are diverse in shape and size. They are created by a shell epithelium which secretes a chitinous periostracum...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160624002884
Delivery Method:
embryo microinjection
Organism or Cell Type:
gastropod mollusc Tritia
Citation Extract:
Dao TK, Ferger K, Lambert JD. A chitin-binding domain-containing gene is essential for shell development in the mollusc Tritia. Dev Biol. 2025 Apr;520:1-12. doi: 10.1016/j.ydbio.2024.12.016. Epub 2024 Dec 24. PMID: 39725261.

TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies

Authors:
Kalanithy JC, Mingardo E, Stegmann JD, Dhakar R, Dakal TC, Rosenfeld JA, Tan WH, Coury SA, Woerner AC, Sebastian J, Levy PA, Fleming LR, Waffenschmidt L, Lindenberg TT, Yilmaz Ö, Channab K, Babra BK, Christ A, Eiberger B, Hölzel S, Vidic C, Häberlein F, Ishorst N, Rodriguez-Gatica JE, Pezeshkpoor B, Kupczyk PA, Vanakker OM, Loddo S, Novelli A, Dentici ML, Becker A, Thiele H, Posey JE, Lupski JR, Hilger AC, Reutter HM, Merz WM, Dworschak GC, Odermatt B
Citation:
J Med Genet. 2025 Jan 27;62(2):126-137. doi: 10.1136/jmg-2023-109799. PMID: 39715634; PMCID: PMC11777392
Epub:
Not Epub
Abstract:
Background: Previous studies in mouse, Xenopus and zebrafish embryos show strong tfap2e expression in progenitor cells of...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11777392/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kalanithy JC, Mingardo E, Stegmann JD, Dhakar R, Dakal TC, Rosenfeld JA, Tan WH, Coury SA, Woerner AC, Sebastian J, Levy PA, Fleming LR, Waffenschmidt L, Lindenberg TT, Yilmaz Ö, Channab K, Babra BK, Christ A, Eiberger B, Hölzel S, Vidic C, Häberlein F, Ishorst N, Rodriguez-Gatica JE, Pezeshkpoor B, Kupczyk PA, Vanakker OM, Loddo S, Novelli A, Dentici ML, Becker A, Thiele H, Posey JE, Lupski JR, Hilger AC, Reutter HM, Merz WM, Dworschak GC, Odermatt B. TFAP2E is implicated in central nervous system, orofacial and maxillofacial anomalies. J Med Genet. 2025 Jan 27;62(2):126-137. doi: 10.1136/jmg-2023-109799. PMID: 39715634; PMCID: PMC11777392.

Frataxin is essential for zebrafish embryogenesis and pronephros formation

Authors:
Ercanbrack WS, Dungan A, Gaul E, Ramirez M, J DelVecchio A, Grass C, Wingert RA
Citation:
Front Cell Dev Biol. 2024 Dec 11;12:1496244. doi: 10.3389/fcell.2024.1496244. PMID: 39723241; PMCID: PMC11669007
Epub:
Not Epub
Abstract:
Background and objectives: Friedreich's Ataxia (FRDA) is a genetic disease that affects a variety of different tissues....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11669007/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ercanbrack WS, Dungan A, Gaul E, Ramirez M, J DelVecchio A, Grass C, Wingert RA. Frataxin is essential for zebrafish embryogenesis and pronephros formation. Front Cell Dev Biol. 2024 Dec 11;12:1496244. doi: 10.3389/fcell.2024.1496244. PMID: 39723241; PMCID: PMC11669007.

The conserved wobble uridine tRNA thiolase Ctu1 is required for angiogenesis and embryonic development

Authors:
Yu Y, Wang C, Wang Y, Shi H, Hu H, Du Y, Zhou Z
Citation:
PLoS One. 2024 Dec 20;19(12):e0315854. doi: 10.1371/journal.pone.0315854. PMID: 39705244; PMCID: PMC11661634
Epub:
Not Epub
Abstract:
Cytosolic thiouridylase is a conserved cytoplasmic tRNA thiolase composed of two different subunits, CTU1 and CTU2. CTU2 serves...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11661634/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu Y, Wang C, Wang Y, Shi H, Hu H, Du Y, Zhou Z. The conserved wobble uridine tRNA thiolase Ctu1 is required for angiogenesis and embryonic development. PLoS One. 2024 Dec 20;19(12):e0315854. doi: 10.1371/journal.pone.0315854. PMID: 39705244; PMCID: PMC11661634.

Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models

Authors:
Ishorst N, Hölzel S, Greve C, Yilmaz Ö, Lindenberg T, Lambertz J, Drichel D, Zametica B, Mingardo E, Kalanithy JC, Channab K, Kibris D, Henne S, Degenhardt F, Siewert A, Dixon M, Kruse T, Ongkosuwito E, Girisha KM, Pande S, Nowak S, Hagelueken G, Geyer M, Carels C, van Rooij IALM, Ludwig KU, Odermatt B, Mangold E
Citation:
Eur J Hum Genet. 2024 Dec 19. doi: 10.1038/s41431-024-01775-9. Epub ahead of print. PMID: 39702590
Epub:
Not Epub
Abstract:
Orofacial clefting (OFC) is a frequent congenital anomaly and can occur either in the context of underlying syndromes or in...
Link:
https://www.nature.com/articles/s41431-024-01775-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ishorst N, Hölzel S, Greve C, Yilmaz Ö, Lindenberg T, Lambertz J, Drichel D, Zametica B, Mingardo E, Kalanithy JC, Channab K, Kibris D, Henne S, Degenhardt F, Siewert A, Dixon M, Kruse T, Ongkosuwito E, Girisha KM, Pande S, Nowak S, Hagelueken G, Geyer M, Carels C, van Rooij IALM, Ludwig KU, Odermatt B, Mangold E. Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models. Eur J Hum Genet. 2024 Dec 19. doi: 10.1038/s41431-024-01775-9. Epub ahead of print. PMID: 39702590.

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