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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12095 scientific papers returned from the database with the search filters currently being used below.

Lymphocyte pathway analysis using naturally lymphocyte-deficient fish

Authors:
Zhang G, Swann J, Felder M, O'Meara C, Boehm T
Citation:
Eur J Immunol. 2023 Aug 18:e2350577. doi: 10.1002/eji.202350577. Online ahead of print
Epub:
Yes
Abstract:
Comparative phylogenetic analyses are of potential value to establish the essential components of genetic networks underlying...
Link:
https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.202350577
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang G, Swann J, Felder M, O'Meara C, Boehm T. Lymphocyte pathway analysis using naturally lymphocyte-deficient fish. Eur J Immunol. 2023 Aug 18:e2350577. doi: 10.1002/eji.202350577. Online ahead of print.

Alternative splicing of its 5’-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

Authors:
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Diz MT, Xu F, Zankharia U, Zhang Y, Soldan S, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Mukta Asnani, Sainos PK, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.02.19.529123
Epub:
Not Epub
Abstract:
Aberrant skipping of coding exons in CD19 and CD22 compromises responses to immunotherapy for B-cell malignancies. Here, we...
Link:
https://www.biorxiv.org/content/10.1101/2023.02.19.529123v3
Delivery Method:
Electroporation, Vivo-Morpholino
Organism or Cell Type:
cell culture: Raji, OCI-Ly8, and MEC-1 cells
Citation Extract:
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Diz MT, Xu F, Zankharia U, Zhang Y, Soldan S, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Mukta Asnani, Sainos PK, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A. Alternative splicing of its 5’-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. bioRxiv. 2023;[preprint] doi:10.1101/2023.02.19.529123 .

Sequence specificity defines the effectiveness of PPMOs targeting Pseudomonas aeruginosa

Authors:
Nanayakkara AK, Moustafa DA, Pifer R, Goldberg JB, Greenberg DE
Citation:
Antimicrob Agents Chemother. 2023 Aug 23:e0024523. doi: 10.1128/aac.00245-23. Online ahead of print
Epub:
Yes
Abstract:
Development of new therapeutics against antibiotic resistant pathogenic bacteria is recognized as a priority across the globe....
Link:
https://journals.asm.org/doi/10.1128/aac.00245-23
Delivery Method:
peptide-linked
Organism or Cell Type:
Pseudomonas aeruginosa (bacterium)
Citation Extract:
Nanayakkara AK, Moustafa DA, Pifer R, Goldberg JB, Greenberg DE. Sequence specificity defines the effectiveness of PPMOs targeting Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2023 Aug 23:e0024523. doi: 10.1128/aac.00245-23. Online ahead of print.

Sphingolipid metabolism is spatially regulated in the developing embryo by SOXE genes

Authors:
Piacentino ML, Fasse AJ, Camacho-Avila A, Grabylnikov I, Bronner ME
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.08.10.552770
Epub:
Not Epub
Abstract:
During epithelial-to-mesenchymal transition (EMT), significant rearrangements occur in plasma membrane protein and lipid...
Link:
https://www.biorxiv.org/content/10.1101/2023.08.10.552770v1
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Piacentino ML, Fasse AJ, Camacho-Avila A, Grabylnikov I, Bronner ME. Sphingolipid metabolism is spatially regulated in the developing embryo by SOXE genes. bioRxiv. 2023;[preprint] doi:10.1101/2023.08.10.552770.

Sclerotome-derived vascular smooth muscle progenitors contribute to the haematopoietic stem cell specification niche

Authors:
Kelley CM, Glenn NO, Gays D, Santoro MM, Clements WK
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.08.09.552695
Epub:
Not Epub
Abstract:
Haematopoietic stem cells (HSCs) are the self-renewing progenitors that continuously populate the haemato-immune cell lineages...
Link:
https://www.biorxiv.org/content/10.1101/2023.08.09.552695v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kelley CM, Glenn NO, Gays D, Santoro MM, Clements WK. Sclerotome-derived vascular smooth muscle progenitors contribute to the haematopoietic stem cell specification niche. bioRxiv. 2023;[preprint] doi:10.1101/2023.08.09.552695.

Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae

Authors:
Tao Z, Yang D, Ni R
Citation:
Dev Biol. 2023 Aug 17:S0012-1606(23)00142-2. doi: 10.1016/j.ydbio.2023.08.003. Online ahead of print
Epub:
Yes
Abstract:
Transmembrane p24 trafficking protein 10 (TMED10) is a conserved vesicle trafficking protein. It is dysregulated in Alzheimer...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160623001422
Organism or Cell Type:
zebrafish
Citation Extract:
Tao Z, Yang D, Ni R. Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae. Dev Biol. 2023 Aug 17:S0012-1606(23)00142-2. doi: 10.1016/j.ydbio.2023.08.003. Online ahead of print.

Protocol for constructing GQD-PMO functionalized FET-biosensor for ultrasensitive exosomal miRNA detection

Authors:
Li K, Liang C, Pan Y, Mei L, Zhang GJ.
Citation:
STAR Protoc. 2023 Aug 16;4(3):102516. doi: 10.1016/j.xpro.2023.102516. Online ahead of print
Epub:
Not Epub
Abstract:
Here, we present a protocol for constructing an ultrasensitive biosensor for exosomal-miRNA detection. We describe steps for...
Link:
https://www.sciencedirect.com/science/article/pii/S2666166723004835
Citation Extract:
Li K, Liang C, Pan Y, Mei L, Zhang GJ.. Protocol for constructing GQD-PMO functionalized FET-biosensor for ultrasensitive exosomal miRNA detection. STAR Protoc. 2023 Aug 16;4(3):102516. doi: 10.1016/j.xpro.2023.102516. Online ahead of print.

Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway

Authors:
Zhou C, Zheng L, Teng H, Yang Y, Ma R, Wang S, Yang Y, Jing J, Li M, Wu R, Chen L, Yao B
Citation:
Reprod Biomed Online. 2023 May 25;47(4):103238. doi: 10.1016/j.rbmo.2023.05.010. Online ahead of print
Epub:
Not Epub
Abstract:
Research question: Is early embryo development in mice influenced by RNA binding protein with multiple splicing 2 (RBPMS2), a...
Link:
https://www.rbmojournal.com/article/S1472-6483(23)00336-X/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
mouse zygote
Citation Extract:
Zhou C, Zheng L, Teng H, Yang Y, Ma R, Wang S, Yang Y, Jing J, Li M, Wu R, Chen L, Yao B. Maternal RNA binding protein with multiple splicing 2 (RBPMS2) is involved in mouse blastocyst formation through the bone morphogenetic protein pathway. Reprod Biomed Online. 2023 May 25;47(4):103238. doi: 10.1016/j.rbmo.2023.05.010. Online ahead of print.

Cfdp1 Is Essential for Cardiac Development and Function

Authors:
Giardoglou P, Deloukas P, Dedoussis G, Beis D
Citation:
Cells. 2023 Aug 3;12(15):1994. doi: 10.3390/cells12151994
Epub:
Not Epub
Abstract:
Cardiovascular diseases (CVDs) are the prevalent cause of mortality worldwide. A combination of environmental and genetic...
Link:
https://www.mdpi.com/2073-4409/12/15/1994
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Giardoglou P, Deloukas P, Dedoussis G, Beis D. Cfdp1 Is Essential for Cardiac Development and Function. Cells. 2023 Aug 3;12(15):1994. doi: 10.3390/cells12151994.

β-Amyloid targeting nanodrug for neuron-specific delivery of nucleic acids in Alzheimer's disease mouse models

Authors:
Israel LL, Sun T, Braubach O, Cox A, Shatalova ES, Rashid HM, Galstyan A, Grodzinski Z, Song XY, Chepurna O, Ljubimov VA, Chiechi A, Sharma S, Phebus C, Wang Y, Ljubimova JY, Black KL, Holler E
Citation:
J Control Release. 2023 Aug 17;361:636-658. doi: 10.1016/j.jconrel.2023.08.001. Online ahead of print
Epub:
Not Epub
Abstract:
Delivery of therapeutic substances into the brain poses a significant challenge in the treatment of neurological disorders....
Link:
https://www.sciencedirect.com/science/article/pii/S0168365923004972
Delivery Method:
nanoparticle
Organism or Cell Type:
mice
Citation Extract:
Israel LL, Sun T, Braubach O, Cox A, Shatalova ES, Rashid HM, Galstyan A, Grodzinski Z, Song XY, Chepurna O, Ljubimov VA, Chiechi A, Sharma S, Phebus C, Wang Y, Ljubimova JY, Black KL, Holler E. β-Amyloid targeting nanodrug for neuron-specific delivery of nucleic acids in Alzheimer's disease mouse models. J Control Release. 2023 Aug 17;361:636-658. doi: 10.1016/j.jconrel.2023.08.001. Online ahead of print.

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