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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes

Authors:
Sundaravel S, Duggan R, Bhagat T, Ebenezer DL, Liu H, Yu Y, Bartenstein M, Unnikrishnan M, Karmakar S, Liu T-C, Torregroza I, Quenon T, Anastasi J, McGraw KL, Pellagatti A, Boultwood J, Yajnik V, Artz A, Le Beau MM, Steidl U, List AF, Evans T, Verma A, Wickrema A
Citation:
PNAS. 2015;112(46):E6359-E6368. doi:10.1073/pnas.1516394112
Epub:
Not Epub
Abstract:
Anemia is the predominant clinical manifestation of myelodysplastic syndromes (MDS). Loss or deletion of chromosome 7 is...
Link:
http://www.pnas.org/content/112/46/E6359.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sundaravel S, Duggan R, Bhagat T, Ebenezer DL, Liu H, Yu Y, Bartenstein M, Unnikrishnan M, Karmakar S, Liu T-C, Torregroza I, Quenon T, Anastasi J, McGraw KL, Pellagatti A, Boultwood J, Yajnik V, Artz A, Le Beau MM, Steidl U, List AF, Evans T, Verma A, Wickrema A. Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes. PNAS. 2015;112(46):E6359-E6368. doi:10.1073/pnas.1516394112.

Complete depletion of primordial germ cells in an All-female fish leads to Sex-biased gene expression alteration and sterile All-male occurrence

Authors:
Liu W, Li S-Z, Li Z, Wang Y, Li X-Y, Zhong J-X, Zhang X-J, Zhang J, Zhou L, Gui J-F
Citation:
BMC Genomics. 2015;16:971 doi:10.1186/s12864-015-2130-z
Epub:
Not Epub
Abstract:
Background: Gynogenesis is one of unisexual reproduction modes in vertebrates, and produces all-female individuals with...
Link:
http://www.biomedcentral.com/1471-2164/16/971
Delivery Method:
microinjection
Organism or Cell Type:
Carassius gibelio (Prussian carp)
Citation Extract:
Liu W, Li S-Z, Li Z, Wang Y, Li X-Y, Zhong J-X, Zhang X-J, Zhang J, Zhou L, Gui J-F. Complete depletion of primordial germ cells in an All-female fish leads to Sex-biased gene expression alteration and sterile All-male occurrence. BMC Genomics. 2015;16:971 doi:10.1186/s12864-015-2130-z.

Nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development

Authors:
Li R-F, Wu T-Y, Mou Y-Z, Wang Y-S, Chen C-L, Wu C-Y
Citation:
J Biomed Sci. 2015;22:104. doi:10.1186/s12929-015-0209-0
Epub:
Yes
Abstract:
Background: The specification of vein and the patterning of intersegmental vessels (ISV) controlled by transcription factor is...
Link:
http://www.jbiomedsci.com/content/22/1/104
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li R-F, Wu T-Y, Mou Y-Z, Wang Y-S, Chen C-L, Wu C-Y. Nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development. J Biomed Sci. 2015;22:104. doi:10.1186/s12929-015-0209-0.

Longitudinal effect of eteplirsen vs. historical control on ambulation in DMD

Authors:
Mendell JR, Goemans N, Lowes LP, Alfano LN, Berry K, Shao J, Kaye EM, Mercuri E, Eteplirsen Study Group, DMD Italian Network
Citation:
Ann Neurol. 2015;[Epub ahead of print] doi:10.1002/ana.24555
Epub:
Yes
Abstract:
Objectives: To continue evaluation of the long-term efficacy and safety of eteplirsen, a phosphorodiamidate morpholino oligomer...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/ana.24555/abstract
Delivery Method:
infusion i.v.
Organism or Cell Type:
humans
Citation Extract:
Mendell JR, Goemans N, Lowes LP, Alfano LN, Berry K, Shao J, Kaye EM, Mercuri E, Eteplirsen Study Group, DMD Italian Network. Longitudinal effect of eteplirsen vs. historical control on ambulation in DMD. Ann Neurol. 2015;[Epub ahead of print] doi:10.1002/ana.24555.

Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells

Authors:
Massouridès E, Polentes J, Mangeot P-E, Mournetas V, Nectoux J, Deburgrave N, Nusbaum P, Leturcq F, Popplewell L, Dickson G, Wein N, Flanigan KM, Peschanski M, Chelly J, Pinset C
Citation:
Skeletal Muscle. 2015;5:40. doi:10.1186/s13395-015-0062-6
Epub:
Not Epub
Abstract:
Background: Duchenne muscular dystrophy (DMD) is a devastating X-linked recessive genetic myopathy. DMD physiopathology is...
Link:
http://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-015-0062-6
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: hiPSCs
Citation Extract:
Massouridès E, Polentes J, Mangeot P-E, Mournetas V, Nectoux J, Deburgrave N, Nusbaum P, Leturcq F, Popplewell L, Dickson G, Wein N, Flanigan KM, Peschanski M, Chelly J, Pinset C. Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells. Skeletal Muscle. 2015;5:40. doi:10.1186/s13395-015-0062-6.

Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway

Authors:
Li S, Dang Y, Zhou X, Huang B, Huang X, Zhang Z, Kwan YW, Chan SW, Leung GPH, Lee SMY, Hoi MPM
Citation:
Sci Rep. 2015;5:16815. doi:10.1038/srep16815
Epub:
Not Epub
Abstract:
Formononetin is an isoflavone that has been shown to display estrogenic properties and induce angiogenesis activities. However...
Link:
http://www.nature.com/articles/srep16815
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li S, Dang Y, Zhou X, Huang B, Huang X, Zhang Z, Kwan YW, Chan SW, Leung GPH, Lee SMY, Hoi MPM. Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway. Sci Rep. 2015;5:16815. doi:10.1038/srep16815.

The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization

Authors:
He Q, Liu K, Tian Z, Du SJ
Citation:
PLoS ONE. 2015;10(11):e0142573. doi:10.1371/journal.pone.0142573
Epub:
Not Epub
Abstract:
Heat shock protein 90α plays a key role in myosin folding and thick filament assembly in muscle cells. To assess the structure...
Link:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142573
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
He Q, Liu K, Tian Z, Du SJ. The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization. PLoS ONE. 2015;10(11):e0142573. doi:10.1371/journal.pone.0142573.

Individual Members of the Microbiota Disproportionately Modulate Host Innate Immune Responses

Authors:
Rolig AS, Parthasarathy R, Burns AR, Bohannan BJM, Guillemin K
Citation:
Cell Host Microbe. 2015;18(5):613-20. doi:10.1016/j.chom.2015.10.009
Epub:
Not Epub
Abstract:
Predicting host health status based on microbial community structure is a major goal of microbiome research. An implicit...
Link:
http://www.cell.com/cell-host-microbe/abstract/S1931-3128%2815%2900419-9
Organism or Cell Type:
zebrafish
Citation Extract:
Rolig AS, Parthasarathy R, Burns AR, Bohannan BJM, Guillemin K. Individual Members of the Microbiota Disproportionately Modulate Host Innate Immune Responses. Cell Host Microbe. 2015;18(5):613-20. doi:10.1016/j.chom.2015.10.009.

Identification of microRNAs and microRNA Targets in Xenopus gastrulae: The role of miR-26 in the regulation of Smad1

Authors:
Liu C, Lou CH, Shah V, Ritter R, Talley J, Soibam B, Benham A, Zhu H, Perez E, Shieh YE, Gunaratne PH, Sater AK
Citation:
Dev Biol. 2015 Nov 5. pii: S0012-1606(15)30277-3. doi: 10.1016/j.ydbio.2015.11.005. [Epub ahead of print]
Epub:
Yes
Abstract:
MicroRNAs (miRNAs) are known to play diverse roles in the regulation of vertebrate development. To investigate miRNA-target...
Link:
http://www.sciencedirect.com/science/article/pii/S0012160615302773
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Liu C, Lou CH, Shah V, Ritter R, Talley J, Soibam B, Benham A, Zhu H, Perez E, Shieh YE, Gunaratne PH, Sater AK. Identification of microRNAs and microRNA Targets in Xenopus gastrulae: The role of miR-26 in the regulation of Smad1. Dev Biol. 2015 Nov 5. pii: S0012-1606(15)30277-3. doi: 10.1016/j.ydbio.2015.11.005. [Epub ahead of print].

Ancestral mesodermal reorganization and evolution of the vertebrate head

Authors:
Onai T, Aramaki T, Inomata H, Hirai T, Kuratani S
Citation:
Zoo Lett. 2015;1:29 doi:10.1186/s40851-015-0030-3
Epub:
Not Epub
Abstract:
Introduction: The vertebrate head is characterized by unsegmented head mesoderm the evolutionary origin of which remains...
Link:
http://zoologicalletters.biomedcentral.com/articles/10.1186/s40851-015-0030-3
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Onai T, Aramaki T, Inomata H, Hirai T, Kuratani S. Ancestral mesodermal reorganization and evolution of the vertebrate head. Zoo Lett. 2015;1:29 doi:10.1186/s40851-015-0030-3.

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