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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

CHD2 variants are a risk factor for photosensitivity in epilepsy

Authors:
Galizia EC, Myers CT, Leu C, de Kovel CG, Afrikanova T, Cordero-Maldonado ML, Martins TG, Jacmin M, Drury S, Krishna Chinthapalli V, Muhle H, Pendziwiat M, Sander T, Ruppert AK, Møller RS, Thiele H, Krause R, Schubert J, Lehesjoki AE, Nürnberg P, Lerche H; EuroEPINOMICS CoGIE Consortium, Palotie A, Coppola A, Striano S, Gaudio LD, Boustred C, Schneider AL, Lench N, Jocic-Jakubi B, Covanis A, Capovilla G, Veggotti P, Piccioli M, Parisi P, Cantonetti L, Sadleir LG, Mullen SA, Berkovic SF, Stephani U, Helbig I, Crawford AD, Esguerra CV, Kasteleijn-Nolst Trenité DG, Koeleman BP, Mefford HC, Scheffer IE, Sisodiya SM
Citation:
Brain. 2015 Mar 17. pii: awv052. [Epub ahead of print]
Epub:
Yes
Abstract:
Photosensitivity is a heritable abnormal cortical response to flickering light, manifesting as particular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Galizia EC, Myers CT, Leu C, de Kovel CG, Afrikanova T, Cordero-Maldonado ML, Martins TG, Jacmin M, Drury S, Krishna Chinthapalli V, Muhle H, Pendziwiat M, Sander T, Ruppert AK, Møller RS, Thiele H, Krause R, Schubert J, Lehesjoki AE, Nürnberg P, Lerche H; EuroEPINOMICS CoGIE Consortium, Palotie A, Coppola A, Striano S, Gaudio LD, Boustred C, Schneider AL, Lench N, Jocic-Jakubi B, Covanis A, Capovilla G, Veggotti P, Piccioli M, Parisi P, Cantonetti L, Sadleir LG, Mullen SA, Berkovic SF, Stephani U, Helbig I, Crawford AD, Esguerra CV, Kasteleijn-Nolst Trenité DG, Koeleman BP, Mefford HC, Scheffer IE, Sisodiya SM. CHD2 variants are a risk factor for photosensitivity in epilepsy. Brain. 2015 Mar 17. pii: awv052. [Epub ahead of print].

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood

Authors:
Nasif S, de Souza FSJ, González LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M
Citation:
PNAS. 2015;[Epub ahead of print] doi:10.1073/pnas.1500672112
Epub:
Yes
Abstract:
Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nasif S, de Souza FSJ, González LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M. Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. PNAS. 2015;[Epub ahead of print] doi:10.1073/pnas.1500672112.

An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system

Authors:
Bestman JE, Huang LC, Lee-Osbourne J, Cheung P, Cline HT
Citation:
Dev Biol. 2015 Dec 15;408(2):269-91. doi: 10.1016/j.ydbio.2015.03.010. Epub 2015 Mar 27.
Epub:
Not Epub
Abstract:
Neurogenesis in the brain of Xenopus laevis continues throughout larval stages of development. We developed a 2-tier screen to...
Delivery Method:
electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bestman JE, Huang LC, Lee-Osbourne J, Cheung P, Cline HT. An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system. Dev Biol. 2015 Dec 15;408(2):269-91. doi: 10.1016/j.ydbio.2015.03.010. Epub 2015 Mar 27..

Mutations in TUBGCP4 Alter Microtubule Organization via the γ-Tubulin Ring Complex in Autosomal-Recessive Microcephaly with Chorioretinopathy

Authors:
Scheidecker S, Etard C, Haren L, Stoetzel C, Hull S, Arno G, Plagnol V, Drunat S, Passemard S, Toutain A, Obringer C, Koob M, Geoffroy V, Marion V, Strähle U, Ostergaard P, Verloes A, Merdes A, Moore AT, Dollfus H
Citation:
Am J Hum Genet. 2015 Mar 25. pii: S0002-9297(15)00064-6. doi: 10.1016/j.ajhg.2015.02.011. [Epub ahead of print]
Epub:
Yes
Abstract:
We have identified TUBGCP4 variants in individuals with autosomal-recessive microcephaly and chorioretinopathy. Whole-exome...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Scheidecker S, Etard C, Haren L, Stoetzel C, Hull S, Arno G, Plagnol V, Drunat S, Passemard S, Toutain A, Obringer C, Koob M, Geoffroy V, Marion V, Strähle U, Ostergaard P, Verloes A, Merdes A, Moore AT, Dollfus H. Mutations in TUBGCP4 Alter Microtubule Organization via the γ-Tubulin Ring Complex in Autosomal-Recessive Microcephaly with Chorioretinopathy. Am J Hum Genet. 2015 Mar 25. pii: S0002-9297(15)00064-6. doi: 10.1016/j.ajhg.2015.02.011. [Epub ahead of print].

In silico screening based on predictive algorithms as a design tool for exon skipping oligonucleotides in duchenne muscular dystrophy

Authors:
Echigoya Y, Mouly V, Garcia L, Yokota T, Duddy W
Citation:
PLoS One. 2015 Mar 27;10(3):e0120058. doi: 10.1371/journal.pone.0120058. eCollection 2015
Epub:
Not Epub
Abstract:
The use of antisense 'splice-switching' oligonucleotides to induce exon skipping represents a potential therapeutic...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human myotubes
Citation Extract:
Echigoya Y, Mouly V, Garcia L, Yokota T, Duddy W. In silico screening based on predictive algorithms as a design tool for exon skipping oligonucleotides in duchenne muscular dystrophy. PLoS One. 2015 Mar 27;10(3):e0120058. doi: 10.1371/journal.pone.0120058. eCollection 2015.

Delivering Antisense Morpholino Oligonucleotides to Target Telomerase Splice Variants in Human Embryonic Stem Cells

Authors:
Radan L, Hughes CS, Teichroeb JH, Postovit LM, Betts DH
Citation:
Methods Mol Biol. 2015 Mar 31. [Epub ahead of print]
Epub:
Yes
Abstract:
Morpholino oligonucleotides (MO) are an innovative tool that provides a means for examining and modifying gene expression...
Organism or Cell Type:
cell culture: human embryonic stem cells
Citation Extract:
Radan L, Hughes CS, Teichroeb JH, Postovit LM, Betts DH. Delivering Antisense Morpholino Oligonucleotides to Target Telomerase Splice Variants in Human Embryonic Stem Cells. Methods Mol Biol. 2015 Mar 31. [Epub ahead of print].

Loss of δ-catenin function in severe autism

Authors:
Turner TN, Sharma K, Oh EC, Liu YP, Collins RL, Sosa MX, Auer DR, Brand H, Sanders SJ, Moreno-De-Luca D, Pihur V, Plona T, Pike K, Soppet DR, Smith MW, Cheung SW, Martin CL, State MW, Talkowski ME, Cook E, Huganir R, Katsanis N, Chakravarti A
Citation:
Nature. 2015 Mar 25. doi: 10.1038/nature14186. [Epub ahead of print]
Epub:
Yes
Abstract:
Autism is a multifactorial neurodevelopmental disorder affecting more males than females; consequently, under a multifactorial...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Turner TN, Sharma K, Oh EC, Liu YP, Collins RL, Sosa MX, Auer DR, Brand H, Sanders SJ, Moreno-De-Luca D, Pihur V, Plona T, Pike K, Soppet DR, Smith MW, Cheung SW, Martin CL, State MW, Talkowski ME, Cook E, Huganir R, Katsanis N, Chakravarti A. Loss of δ-catenin function in severe autism. Nature. 2015 Mar 25. doi: 10.1038/nature14186. [Epub ahead of print].

Midkine-a Protein Localization in the Developing and Adult Retina of the Zebrafish and Its Function During Photoreceptor Regeneration

Authors:
Gramage E, D'Cruz T, Taylor S, Thummel R, Hitchcock PF
Citation:
PLoS One. 2015 Mar 24;10(3):e0121789. doi: 10.1371/journal.pone.0121789. eCollection 2015
Epub:
Not Epub
Abstract:
Midkine is a heparin binding growth factor with important functions in neuronal development and survival, but little is known...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gramage E, D'Cruz T, Taylor S, Thummel R, Hitchcock PF. Midkine-a Protein Localization in the Developing and Adult Retina of the Zebrafish and Its Function During Photoreceptor Regeneration. PLoS One. 2015 Mar 24;10(3):e0121789. doi: 10.1371/journal.pone.0121789. eCollection 2015.

Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin

Authors:
Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, Uhlén M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J
Citation:
PLoS One. 2015 Mar 25;10(3):e0122067. doi: 10.1371/journal.pone.0122067. eCollection 2015
Epub:
Not Epub
Abstract:
BACKGROUND: Podocyte foot process effacement accompanied by actin cytoskeleton rearrangements is a cardinal feature of many...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, Uhlén M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J. Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin. PLoS One. 2015 Mar 25;10(3):e0122067. doi: 10.1371/journal.pone.0122067. eCollection 2015.

slc7a6os Gene Plays a Critical Role in Defined Areas of the Developing CNS in Zebrafish

Authors:
Benini A, Cignarella F, Calvarini L, Mantovanelli S, Giacopuzzi E, Zizioli D, Borsani G
Citation:
PLoS One. 2015 Mar 24;10(3):e0119696. doi: 10.1371/journal.pone.0119696. eCollection 2015
Epub:
Not Epub
Abstract:
The aim of this study is to shed light on the functional role of slc7a6os, a gene highly conserved in vertebrates. The Danio...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Benini A, Cignarella F, Calvarini L, Mantovanelli S, Giacopuzzi E, Zizioli D, Borsani G. slc7a6os Gene Plays a Critical Role in Defined Areas of the Developing CNS in Zebrafish. PLoS One. 2015 Mar 24;10(3):e0119696. doi: 10.1371/journal.pone.0119696. eCollection 2015.

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