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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
Development of the morpholino gene knockdown technique in Fundulus heteroclitus: A tool for studying molecular mechanisms in an established environmental model
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Citation:
Aquat Toxicol. 2008 May 30;87(4):289-95. Epub 2008 Feb 23. Epub:
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A significant challenge in environmental toxicology is that many genetic and genomic tools available in laboratory models are... Delivery Method:
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Fundulus heteroclitus Citation Extract: Matson CW, Clark BW, Jenny MJ, Fleming CR, Hahn ME, Di Giulio RT. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: A tool for studying molecular mechanisms in an established environmental model. Aquat Toxicol. 2008 May 30;87(4):289-95. Epub 2008 Feb 23.. |
Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia
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Blood. 2003 Oct 15;102(8):2969-75. Epub 2003 Jul 3 Epub:
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An internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 (FLT3/ITD) has been found in 20% of patients with... Delivery Method:
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cell culture: human leukemia MOLM-13 (AML-M5a with FLT3/ITD) Citation Extract: Minami Y, Yamamoto K, Kiyoi H, Ueda R, Saito H, Naoe T. Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. Blood. 2003 Oct 15;102(8):2969-75. Epub 2003 Jul 3. |
Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells
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Leukemia. 2003 Feb;17(2):390-400 Epub:
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Neutrophils and monocytes/macrophages are derived from common progenitors, but exhibit markedly different lifespans.... Delivery Method:
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cell culture: HL60 cells Citation Extract: Miranda MB, Dyer KF, Grandis JR, Johnson DE. Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells. Leukemia. 2003 Feb;17(2):390-400. |
Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA
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Development. 2008 May;135(10):1771-80. Epub 2008 Apr 9. Epub:
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Directed cell migration is crucial for development, but most of our current knowledge is derived from in vitro studies. We... Citation Extract: Matthews HK, Marchant L, Carmona-Fontaine C, Kuriyama S, Larraín J, Holt MR, Parsons M, Mayor R. Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. Development. 2008 May;135(10):1771-80. Epub 2008 Apr 9.. |
Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish
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Dev Biol. 2011 Nov 6. [Epub ahead of print] Epub:
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Analysis of zebrafish mutants that have defects in motor behavior can allow entrée into the hindbrain and spinal cord networks... Delivery Method:
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zebrafish Citation Extract: McKeown KA, Moreno R, Hall VL, Ribera AB, Downes GB. Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish. Dev Biol. 2011 Nov 6. [Epub ahead of print]. |
Diversification of oral and aboral mesodermal regulatory states in pregastrular sea urchin embryos
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Citation:
Dev Biol. 2013 Mar 1;375(1):92-104. doi: 10.1016/j.ydbio.2012.11.033. Epub 2012 Dec 19 Epub:
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Specification of the non-skeletogenic mesoderm (NSM) in sea urchin embryos depends on Delta signaling. Signal reception leads... Delivery Method:
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sea urchin Citation Extract: Materna SC, Ransick A, Li E, Davidson EH. Diversification of oral and aboral mesodermal regulatory states in pregastrular sea urchin embryos. Dev Biol. 2013 Mar 1;375(1):92-104. doi: 10.1016/j.ydbio.2012.11.033. Epub 2012 Dec 19. |
Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization
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Circulation. 2009 Aug 18;120(7):553-9. Epub 2009 Aug 3 Epub:
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BACKGROUND: Cardiac repolarization, the process by which cardiomyocytes return to their resting potential after each beat, is a... Delivery Method:
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zebrafish Citation Extract: Milan DJ, Kim AM, Winterfield JR, Jones IL, Pfeufer A, Sanna S, Arking DE, Amsterdam AH, Sabeh KM, Mably JD, Rosenbaum DS, Peterson RT, Chakravarti A, Kääb S, Roden DM, MacRae CA. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Circulation. 2009 Aug 18;120(7):553-9. Epub 2009 Aug 3. |
Drugs that induce repolarization abnormalities cause bradycardia in zebrafish
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Circulation. 2003 Mar 18;107(10):1355-8. Epub:
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BACKGROUND: Drug-induced QT prolongation and torsades de pointes remain significant and often unpredictable clinical problems.... Delivery Method:
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zebrafish Citation Extract: Milan DJ, Peterson TA, Ruskin JN, Peterson RT, MacRae CA. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation. 2003 Mar 18;107(10):1355-8.. |
Eteplirsen for the treatment of duchenne muscular dystrophy
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Ann Neurol. 2013;74(5):637-647 doi:10.1002/ana.23982 Epub:
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Objective In prior open-label studies, eteplirsen, a phosphorodiamidate morpholino oligomer (PMO), enabled dystrophin... Delivery Method:
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human Citation Extract: Mendell J, Rodino-Klapac LR, Sahenk Z, Roush K, Bird L, Lowes LP, Alfano L, Gomez AM, Lewis S, Kota J, Malik V, Shontz K, Walker CM, Flanigan KM, Kean JR, Allen HD, Shilling C, Melia KR, Sazani P, Saoud JB, Kaye EM, The Eteplirsen Study Group. Eteplirsen for the treatment of duchenne muscular dystrophy. Ann Neurol. 2013;74(5):637-647 doi:10.1002/ana.23982. |
Extracellular cleavage of cadherin-11 by ADAM metalloproteases is essential for Xenopus cranial neural crest cell migration
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Citation:
Mol Biol Cell. 2009 Jan;20(1):78-89. Epub 2008 Oct 22. Erratum in: Mol Biol Cell. 2010 May;21(9):1643 Epub:
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Cell adhesion molecules such as cadherins alternate their expression throughout cranial neural crest (CNC) development, yet our... Delivery Method:
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Xenopus laevis Citation Extract: McCusker C, Cousin H, Neuner R, Alfandari D. Extracellular cleavage of cadherin-11 by ADAM metalloproteases is essential for Xenopus cranial neural crest cell migration. Mol Biol Cell. 2009 Jan;20(1):78-89. Epub 2008 Oct 22. Erratum in: Mol Biol Cell. 2010 May;21(9):1643. |