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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Far-red fluorescent genetically encoded calcium ion indicators

Authors:
Dalangin R, Jia BZ, Qi Y, Aggarwal A, Sakoi K, Drobizhev M, Molina RS, Patel R, Abdelfattah AS, Zheng J, Reep D, Hasseman JP; GENIE Project Team; Zhao Y, Wu J, Podgorski K, Tebo AG, Schreiter ER, Hughes TE, Terai T, Paquet ME, Megason SG, Cohen AE, Shen Y, Campbell RE
Citation:
Nat Commun. 2025 Apr 7;16(1):3318. doi: 10.1038/s41467-025-58485-z. PMID: 40195305
Epub:
Not Epub
Abstract:
Genetically encoded calcium ion (Ca2+) indicators (GECIs) are widely-used molecular tools for functional imaging of Ca2+...
Link:
https://www.nature.com/articles/s41467-025-58485-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dalangin R, Jia BZ, Qi Y, Aggarwal A, Sakoi K, Drobizhev M, Molina RS, Patel R, Abdelfattah AS, Zheng J, Reep D, Hasseman JP; GENIE Project Team; Zhao Y, Wu J, Podgorski K, Tebo AG, Schreiter ER, Hughes TE, Terai T, Paquet ME, Megason SG, Cohen AE, Shen Y, Campbell RE. Far-red fluorescent genetically encoded calcium ion indicators. Nat Commun. 2025 Apr 7;16(1):3318. doi: 10.1038/s41467-025-58485-z. PMID: 40195305.

Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis

Authors:
Leon-Icaza SA, Frétaud M, Cornélie S, Bureau C, Yatime L, Floto RA, Renshaw SA, Herrmann JL, Langevin C, Cougoule C, Bernut A
Citation:
Biomed Pharmacother. 2025 Mar 31;186:117957. doi: 10.1016/j.biopha.2025.117957. Epub ahead of print. PMID: 40168724
Epub:
Not Epub
Abstract:
Background: Overactive neutrophilic inflammation causes damage to the airways and death in people with cystic fibrosis (CF), a...
Link:
https://www.sciencedirect.com/science/article/pii/S0753332225001519
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Leon-Icaza SA, Frétaud M, Cornélie S, Bureau C, Yatime L, Floto RA, Renshaw SA, Herrmann JL, Langevin C, Cougoule C, Bernut A. Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis. Biomed Pharmacother. 2025 Mar 31;186:117957. doi: 10.1016/j.biopha.2025.117957. Epub ahead of print. PMID: 40168724.

Probe-Screened Carbon Nanotube Field-Effect Transistor Biosensor to Enhance Breast Cancer-Related Gene Assay

Authors:
Liu P, Liu Y, Cai B, Li J, Zhang G-J
Citation:
Green Analytical Chemistry (2025) 100267, ISSN 2772-5774, doi.org/10.1016/j.greeac.2025.100267
Epub:
Not Epub
Abstract:
BRCA1 gene testing is a trump card for liquid biopsy and early diagnosis in breast cancer, which has been limited, however, by...
Link:
/www.sciencedirect.com/science/article/pii/S2772577425000631
Delivery Method:
None
Organism or Cell Type:
DNA samples extracted from BRCA1-mutated breast cancer patients and healthy controls
Citation Extract:
Liu P, Liu Y, Cai B, Li J, Zhang G-J. Probe-Screened Carbon Nanotube Field-Effect Transistor Biosensor to Enhance Breast Cancer-Related Gene Assay. Green Analytical Chemistry (2025) 100267, ISSN 2772-5774, doi.org/10.1016/j.greeac.2025.100267.

Evi1 is necessary for late activation of delta-notch signaling in sea urchin embryos

Authors:
Anand S & McClay D
Citation:
bioRxiv [preprint] 2025.04.01.646662; doi: https://doi.org/10.1101/2025.04.01.646662
Epub:
Not Epub
Abstract:
Embryonic mesoderm specification and differentiation rely on intricate gene regulatory networks. In sea urchin embryos,...
Link:
https://www.biorxiv.org/content/10.1101/2025.04.01.646662v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus (sea urchin)
Citation Extract:
Anand S & McClay D. Evi1 is necessary for late activation of delta-notch signaling in sea urchin embryos. bioRxiv [preprint] 2025.04.01.646662; doi: https://doi.org/10.1101/2025.04.01.646662.

SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish

Authors:
Oh CK, Kim MS, Shin U, Kang JW, Kim YH, Ko HS, Ra JS, Ahn S, Choi EY, Yu S, Nam U, Choi T, Myung K, Lee Y
Citation:
J Cell Physiol. 2025 Mar;240(3):e70023. doi: 10.1002/jcp.70023. PMID: 40134128; PMCID: PMC11937623
Epub:
Not Epub
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health and...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/jcp.70023
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oh CK, Kim MS, Shin U, Kang JW, Kim YH, Ko HS, Ra JS, Ahn S, Choi EY, Yu S, Nam U, Choi T, Myung K, Lee Y. SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish. J Cell Physiol. 2025 Mar;240(3):e70023. doi: 10.1002/jcp.70023. PMID: 40134128; PMCID: PMC11937623.

Zebrafish TDP43 positively regulates p65-mediated apoptotic pathway

Authors:
Yu T, Li M, Li M, Zhang Q, Zhang H, Jiang Z, Wang S, Mao H, Li D, Fan L, Hu C, Xu X
Citation:
Int J Biol Macromol. 2025 Mar 27:142599. doi: 10.1016/j.ijbiomac.2025.142599. Epub ahead of print. PMID: 40157684
Epub:
Not Epub
Abstract:
TAR DNA-binding protein 43 (TDP43) is a multifunctional RNA/DNA binding protein that serves as a hallmark of neurodegeneration...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0141813025031514
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu T, Li M, Li M, Zhang Q, Zhang H, Jiang Z, Wang S, Mao H, Li D, Fan L, Hu C, Xu X. Zebrafish TDP43 positively regulates p65-mediated apoptotic pathway. Int J Biol Macromol. 2025 Mar 27:142599. doi: 10.1016/j.ijbiomac.2025.142599. Epub ahead of print. PMID: 40157684.

OPN3-mediated positive regulation of angiogenesis in HUVECs through VEGFR2 interaction

Authors:
Luo H, Zhang W, Zeng W, Wang Y, Feng J, Lan Y, Dong X, Liu T, Sun Y, Lu H
Citation:
Commun Biol. 2025 Mar 31;8(1):529. doi: 10.1038/s42003-025-07958-4. PMID: 40164822; PMCID: PMC11958745
Epub:
Not Epub
Abstract:
Many rhodopsin-like G-protein-coupled receptors (Rh-GPCRs) are known to either promote or inhibit angiogenesis. Among these,...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11958745/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Luo H, Zhang W, Zeng W, Wang Y, Feng J, Lan Y, Dong X, Liu T, Sun Y, Lu H. OPN3-mediated positive regulation of angiogenesis in HUVECs through VEGFR2 interaction. Commun Biol. 2025 Mar 31;8(1):529. doi: 10.1038/s42003-025-07958-4. PMID: 40164822; PMCID: PMC11958745.

Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Pudlak syndrome

Authors:
Yong X, Jia G, Yang Q, Zhou C, Zhang S, Deng H, Billadeau DD, Su Z, Jia D
Citation:
Nat Commun. 2025 Mar 26;16(1):2967. doi: 10.1038/s41467-025-58235-1. PMID: 40140412; PMCID: PMC11947305
Epub:
Not Epub
Abstract:
Biogenesis of lysosome-related organelle complex-3 (BLOC-3) is pivotal in vesicle trafficking and has been linked to Hermansky-...
Link:
https://www.nature.com/articles/s41467-025-58235-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yong X, Jia G, Yang Q, Zhou C, Zhang S, Deng H, Billadeau DD, Su Z, Jia D. Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Pudlak syndrome. Nat Commun. 2025 Mar 26;16(1):2967. doi: 10.1038/s41467-025-58235-1. PMID: 40140412; PMCID: PMC11947305.

Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model

Authors:
Bestas B, Estupiñán HY, Wang Q, Kharazi S, He C, K Mohammad D, Gupta D, Wiklander OPB, Lehto T, Lundin KE, Berglöf A, Karlsson MCI, Abendroth F, El Andaloussi S, Gait MJ, Wood MJA, Leumann CJ, Stetsenko DA, Månsson R, Wengel J, Zain R, Smith CIE
Citation:
RSC Chem Biol. 2025 Mar 31. doi: 10.1039/d4cb00312h. Epub ahead of print. PMID: 40171248; PMCID: PMC11955834
Epub:
Not Epub
Abstract:
Splice-switching oligonucleotides (SSOs) have been developed as a treatment for various disorders, including Duchenne muscular...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11955834/
Delivery Method:
Pip6a peptide-linked; intravenous (i.v.) injection
Organism or Cell Type:
cell culture: 2OS luciferase reporter cell line containing a mutated BTK intron 4, primary B cells with mutant BTK transcript; mice: BAC transgenic mice with full-length mutated human BTK pre-mRNA
Citation Extract:
Bestas B, Estupiñán HY, Wang Q, Kharazi S, He C, K Mohammad D, Gupta D, Wiklander OPB, Lehto T, Lundin KE, Berglöf A, Karlsson MCI, Abendroth F, El Andaloussi S, Gait MJ, Wood MJA, Leumann CJ, Stetsenko DA, Månsson R, Wengel J, Zain R, Smith CIE. Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model. RSC Chem Biol. 2025 Mar 31. doi: 10.1039/d4cb00312h. Epub ahead of print. PMID: 40171248; PMCID: PMC11955834.

Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish

Authors:
Wang X, Liu M, Zhang Y, Ma D, Wang L, Liu F
Citation:
Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420534122. doi: 10.1073/pnas.2420534122. Epub 2025 Mar 20. PMID: 40112113
Epub:
Not Epub
Abstract:
During fetal stage, hematopoietic stem and progenitor cells (HSPCs) undergo rapid proliferation with a tight control of genomic...
Link:
https://www.pnas.org/doi/10.1073/pnas.2420534122
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang X, Liu M, Zhang Y, Ma D, Wang L, Liu F. Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420534122. doi: 10.1073/pnas.2420534122. Epub 2025 Mar 20. PMID: 40112113.

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