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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

RPS24 haploinsufficiency impairs erythropoiesis in the Diamond-Blackfan anemia zebrafish model via the STAT6-SATB1 pathway

Authors:
Ahn S, Oh CK. R
Citation:
Biochem Biophys Res Commun. 2025 Apr 5;756:151563. doi: 10.1016/j.bbrc.2025.151563. Epub 2025 Mar 1. PMID: 40054062
Epub:
Not Epub
Abstract:
Diamond-Blackfan anemia (DBA) is a rare bone marrow failure disorder primarily caused by mutations in ribosomal proteins (RPs...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X25002773
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ahn S, Oh CK. R. RPS24 haploinsufficiency impairs erythropoiesis in the Diamond-Blackfan anemia zebrafish model via the STAT6-SATB1 pathway. Biochem Biophys Res Commun. 2025 Apr 5;756:151563. doi: 10.1016/j.bbrc.2025.151563. Epub 2025 Mar 1. PMID: 40054062.

Phosphorodiamidate Morpholino Oligomers-Loaded Nanobubbles for Ultrasound-Mediated Delivery to the Myocardium in Muscular Dystrophy

Authors:
Endo-Takahashi Y, Sakurai A, Oguri Y, Katagiri F, Akiyama S, Sashida S, Yamaguchi T, Marunouchi T, Suzuki R, Maruyama K, Tanonaka K, Nomizu M, Negishi Y
Citation:
ACS Omega Article ASAP. doi: 10.1021/acsomega.4c10896
Epub:
Not Epub
Abstract:
Microbubbles (MBs) and nanobubbles (NBs) can oscillate and collapse in response to ultrasound exposure, resulting in contrast...
Link:
https://pubs.acs.org/doi/10.1021/acsomega.4c10896
Delivery Method:
R8 peptide-linked; intravenous (i.v.) injection
Organism or Cell Type:
mice: C57BL/10ScSnmdx
Citation Extract:
Endo-Takahashi Y, Sakurai A, Oguri Y, Katagiri F, Akiyama S, Sashida S, Yamaguchi T, Marunouchi T, Suzuki R, Maruyama K, Tanonaka K, Nomizu M, Negishi Y. Phosphorodiamidate Morpholino Oligomers-Loaded Nanobubbles for Ultrasound-Mediated Delivery to the Myocardium in Muscular Dystrophy. ACS Omega Article ASAP. doi: 10.1021/acsomega.4c10896.

Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo

Authors:
Tarbashevich K, Ghosh A, Das A, Kuilya D, Shrama SN, Sinha S, Raz E
Citation:
Nat Commun 16, 3614 (2025). https://doi.org/10.1038/s41467-025-58207-5
Epub:
Not Epub
Abstract:
A key regulatory step in protein synthesis is the initiation of mRNA translation. We developed an efficient, robust, and...
Link:
https://www.nature.com/articles/s41467-025-58207-5
Delivery Method:
microinjection, UV-photocleavable Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Tarbashevich K, Ghosh A, Das A, Kuilya D, Shrama SN, Sinha S, Raz E. Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo. Nat Commun 16, 3614 (2025). https://doi.org/10.1038/s41467-025-58207-5.

NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish

Authors:
Chen YL, Chung BH, Mimaki M, Uchino S, Chien YH, Mak CC, Peng SS, Wang WC, Lin YL, Hwu WL, Lee SJ, Lee NC
Citation:
Cell Death Discov. 2025 Mar 1;11(1):82. doi: 10.1038/s41420-025-02369-0. PMID: 40025060
Epub:
Not Epub
Abstract:
Complex I of the mitochondrial electron transfer chain is one of the largest membrane protein assemblies ever discovered. A...
Link:
https://www.nature.com/articles/s41420-025-02369-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen YL, Chung BH, Mimaki M, Uchino S, Chien YH, Mak CC, Peng SS, Wang WC, Lin YL, Hwu WL, Lee SJ, Lee NC. NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish. Cell Death Discov. 2025 Mar 1;11(1):82. doi: 10.1038/s41420-025-02369-0. PMID: 40025060.

Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis

Authors:
Coßmann J, Kos PI, Varamogianni-Mamatsi V, Assenheimer DS, Bischof TA, Kuhn T, Vomhof T, Papantonis A, Giorgetti L, Gebhardt JCM
Citation:
Nat Commun. 2025 Feb 21;16(1):1833. doi: 10.1038/s41467-025-56889-5. PMID: 39979259; PMCID: PMC11842872
Epub:
Not Epub
Abstract:
The three-dimensional folding of chromosomes is essential for nuclear functions such as DNA replication and gene regulation....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11842872/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Coßmann J, Kos PI, Varamogianni-Mamatsi V, Assenheimer DS, Bischof TA, Kuhn T, Vomhof T, Papantonis A, Giorgetti L, Gebhardt JCM. Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis. Nat Commun. 2025 Feb 21;16(1):1833. doi: 10.1038/s41467-025-56889-5. PMID: 39979259; PMCID: PMC11842872.

Nance-Horan-syndrome-like 1b controls mesodermal cell migration by regulating protrusion and actin dynamics during zebrafish gastrulation

Authors:
Escot S, Hassanein Y, Elouin A, Torres-Paz J, Mellottee L, Ignace A, David NB
Citation:
Commun Biol. 2025 Feb 28;8(1):328. doi: 10.1038/s42003-025-07689-6. PMID: 40021913; PMCID: PMC11871229
Epub:
Not Epub
Abstract:
Cell migrations are crucial for embryonic development, wound healing, the immune response, as well as for cancer progression....
Link:
https://www.nature.com/articles/s42003-025-07689-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Escot S, Hassanein Y, Elouin A, Torres-Paz J, Mellottee L, Ignace A, David NB. Nance-Horan-syndrome-like 1b controls mesodermal cell migration by regulating protrusion and actin dynamics during zebrafish gastrulation. Commun Biol. 2025 Feb 28;8(1):328. doi: 10.1038/s42003-025-07689-6. PMID: 40021913; PMCID: PMC11871229.

Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs

Authors:
Feng Q, Lin Z, Zhao D, Li M, Yang S, Xiang AP, Ye C, Yao C
Citation:
Cell Rep. 2025 Mar 25;44(3):115376. doi: 10.1016/j.celrep.2025.115376. Epub 2025 Feb 27. PMID: 40019833
Epub:
Not Epub
Abstract:
The catalytic role of U6 snRNP in pre-mRNA splicing has been well established. In this study, we utilize an antisense...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00147-0
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HeLa, HEK-293, SW480, NIH3T3, Neuro-2a
Citation Extract:
Feng Q, Lin Z, Zhao D, Li M, Yang S, Xiang AP, Ye C, Yao C. Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs. Cell Rep. 2025 Mar 25;44(3):115376. doi: 10.1016/j.celrep.2025.115376. Epub 2025 Feb 27. PMID: 40019833.

The temporal control and activity of maternal zsquildlike-A/hnrnpaba during zebrafish embryogenesis indicate a role in early pattern formation

Authors:
Molnar N, Capik A, Ishak A, Maglakelidze N, Pasick LJ, Reneker B, Volino A, O'Connell ML
Citation:
Zygote. 2025 Feb 25:1-11. doi: 10.1017/S0967199425000024. Epub ahead of print. PMID: 39995299
Epub:
Not Epub
Abstract:
During embryogenesis in Danio rerio (zebrafish), the earliest morphological patterning events are dependent on the precise...
Link:
https://www.cambridge.org/core/journals/zygote/article/temporal-control-and-activity-of-maternal-zsquildlikeahnrnpaba-during-zebrafish-embryogenesis-indicate-a-role-in-early-pattern-formation/98A933EFB75A071E5D31123CAB6CBC3C
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Molnar N, Capik A, Ishak A, Maglakelidze N, Pasick LJ, Reneker B, Volino A, O'Connell ML. The temporal control and activity of maternal zsquildlike-A/hnrnpaba during zebrafish embryogenesis indicate a role in early pattern formation. Zygote. 2025 Feb 25:1-11. doi: 10.1017/S0967199425000024. Epub ahead of print. PMID: 39995299.

Targeting a Novel Site in Exon 51 with Antisense Oligonucleotides Induces Enhanced Exon Skipping in a Mouse Model of Duchenne Muscular Dystrophy

Authors:
Oppeneer T, Qi Y, Henshaw J, Larimore K, Melton A, Puoliväli J, Carter C, Fant P, Brennan S, Wetzel LA, Sigg MA, Crawford BE, Magat J, Froelich S, Woloszynek JC, O'Neill CA
Citation:
Nucleic Acid Ther. 2025 Feb 7. doi: 10.1089/nat.2024.0049. Epub ahead of print. PMID: 39916530
Epub:
Not Epub
Abstract:
Exon skipping with antisense oligonucleotides (ASOs) can correct disease-causing mutations of Duchenne muscular dystrophy (DMD...
Link:
https://www.liebertpub.com/doi/10.1089/nat.2024.0049
Delivery Method:
peptide-linked or bare oligo intravenous (i.v.) injection
Organism or Cell Type:
hDMDdel52/mdx mice
Citation Extract:
Oppeneer T, Qi Y, Henshaw J, Larimore K, Melton A, Puoliväli J, Carter C, Fant P, Brennan S, Wetzel LA, Sigg MA, Crawford BE, Magat J, Froelich S, Woloszynek JC, O'Neill CA. Targeting a Novel Site in Exon 51 with Antisense Oligonucleotides Induces Enhanced Exon Skipping in a Mouse Model of Duchenne Muscular Dystrophy. Nucleic Acid Ther. 2025 Feb 7. doi: 10.1089/nat.2024.0049. Epub ahead of print. PMID: 39916530.

Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos

Authors:
Azbazdar Y, De Robertis EM
Citation:
Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2421772122. doi: 10.1073/pnas.2421772122. Epub 2025 Feb 10. PMID: 39928870; PMCID: PMC11848351
Epub:
Not Epub
Abstract:
We recently reported that microinjection of Xenopus nodal-related (xnr) mRNAs into β-catenin-depleted Xenopus embryos rescued a...
Link:
https://www.pnas.org/doi/10.1073/pnas.2421772122
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Azbazdar Y, De Robertis EM. Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos. Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2421772122. doi: 10.1073/pnas.2421772122. Epub 2025 Feb 10. PMID: 39928870; PMCID: PMC11848351.

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