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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
Viltolarsen: From Preclinical Studies to FDA Approval
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Citation:
Methods Mol Biol. 2023;2587:31-41. doi: 10.1007/978-1-0716-2772-3_2 Epub:
Not Epub Abstract:
Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide (PMO) designed to skip exon 53 of the DMD gene for the... Citation Extract: Roshmi RR, Yokota T. Viltolarsen: From Preclinical Studies to FDA Approval. Methods Mol Biol. 2023;2587:31-41. doi: 10.1007/978-1-0716-2772-3_2. |
DNAJB6 Isoform Specific Knockdown: Therapeutic Potential for LGMDD1
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.17.516920 Epub:
Not Epub Abstract:
Dominant missense mutations in DNAJB6, an HSP40 co-chaperone, cause limb girdle muscular dystrophy (LGMD) D1. No treatments are... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: mouse myotubes & human myotubes, mice Citation Extract: Findlay AR, Paing MM, Daw JA, Bengoechea R, Pittman SK, Li S, Wang F, Miller TM, True HL, Weihl CC. DNAJB6 Isoform Specific Knockdown: Therapeutic Potential for LGMDD1. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.17.516920. |
Functional identification of the zebrafish Interleukin-1 receptor in an embryonic model of Il-1β-induced systemic inflammation
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Citation:
Front Immunol. 2022 Oct 26;13:1039161. doi: 10.3389/fimmu.2022.1039161. eCollection 2022 Epub:
Not Epub Abstract:
Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that plays a vital role in the innate immune system. To observe the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sebo DJ, Fetsko AR, Phipps KK, Taylor MR. Functional identification of the zebrafish Interleukin-1 receptor in an embryonic model of Il-1β-induced systemic inflammation. Front Immunol. 2022 Oct 26;13:1039161. doi: 10.3389/fimmu.2022.1039161. eCollection 2022. |
An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes
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Citation:
Nat Ecol Evol. 2022;[Epub] doi:10.1038/s41559-022-01905-w Epub:
Yes Abstract:
Transcription factors are crucial drivers of cellular differentiation during animal development and often share ancient... Citation Extract: Schwaiger M, Andrikou C, Dnyansagar R, Murguia PF, Paganos P, Voronov D, Zimmermann B, Lebedeva T, Schmidt HA, Genikhovich G, Benvenuto G, Arnone MI, Technau U. An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes. Nat Ecol Evol. 2022;[Epub] doi:10.1038/s41559-022-01905-w. |
Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis
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Citation:
PLoS One. 2022 Nov 16;17(11):e0276255. doi: 10.1371/journal.pone.0276255. eCollection 2022 Epub:
Not Epub Abstract:
E26 transformation specific (ETS) family transcription factors are expressed during embryogenesis and are involved in various... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sarmah S, Hawkins MR, Manikandan P, Farrell M, Marrs JA. Elf3 deficiency during zebrafish development alters extracellular matrix organization and disrupts tissue morphogenesis. PLoS One. 2022 Nov 16;17(11):e0276255. doi: 10.1371/journal.pone.0276255. eCollection 2022. |
NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
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Citation:
microPubl Biol. 2022;[Epub] doi:10.17912/micropub.biology.000682 Epub:
Not Epub Abstract:
NeuroD is a transcription factor (TF) that plays a dual role in vertebrate neurogenesis and glucose homeostasis in the pancreas... Delivery Method:
microinjection Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin) Citation Extract: Konrad KD, Song JL. NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae. microPubl Biol. 2022;[Epub] doi:10.17912/micropub.biology.000682. |
Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation
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Citation:
Int J Mol Sci. 2022;23:14182. doi:/10.3390/ijms232214182 Epub:
Not Epub Abstract:
cAMP-PKA signaling plays a pivotal role in melanin synthesis and melanosome transport by responding to the binding of the α-... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang L, Wan M, Tohti R, Jin D, Zhong TP. Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation. Int J Mol Sci. 2022;23:14182. doi:/10.3390/ijms232214182. |
Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration
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Citation:
Cell Stem Cell. 2022;[Epub] doi:10.1016/j.stem.2022.10.009 Epub:
Yes Abstract:
In aging, skeletal muscle strength and regenerative capacity decline, due in part to functional impairment of muscle stem cells... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: mouse muscle stem cells Citation Extract: Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf KI, Frésard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM. Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. Cell Stem Cell. 2022;[Epub] doi:10.1016/j.stem.2022.10.009. |
X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems
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Citation:
J Med Genet. 2022 Nov 15:jmedgenet-2022-108738. doi: 10.1136/jmg-2022-108738. Online ahead of print Epub:
Yes Abstract:
Background: SHROOM4 is thought to play an important role in cytoskeletal modification and development of the early nervous... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kolvenbach CM, Felger T, Schierbaum L, Thiffault I, Pastinen T, Szczepańska M, Zaniew M, Adamczyk P, Bayat A, Yilmaz Ö, Lindenberg TT, Thiele H, Hildebrandt F, Hinderhofer K, Moog U, Hilger AC, Sullivan B, Bartik L, Gnyś P, Grote P, Odermatt B, Reutter HM, Dworschak GC. X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems. J Med Genet. 2022 Nov 15:jmedgenet-2022-108738. doi: 10.1136/jmg-2022-108738. Online ahead of print. |
Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction
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Citation:
Dev Biol. 2020 Apr 15;460(2):108-114. doi: 10.1016/j.ydbio.2019.12.015. Epub 2019 Dec 25 Epub:
Not Epub Abstract:
Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Pegge J, Tatsinkam AJ, Rider CC, Bell E. Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction. Dev Biol. 2020 Apr 15;460(2):108-114. doi: 10.1016/j.ydbio.2019.12.015. Epub 2019 Dec 25. |