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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Antibody-oligonucleotide conjugate achieves central nervous system delivery in animal models for spinal muscular atrophy

Authors:
Hammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI
Citation:
JCI Insight. 2022 Nov 8:e154142. doi: 10.1172/jci.insight.154142. Online ahead of print
Epub:
Yes
Abstract:
Antisense oligonucleotides (ASOs) have emerged as one of the most innovative new genetic drug modalities. However, their high...
Link:
https://insight.jci.org/articles/view/154142
Delivery Method:
antibody-linked
Organism or Cell Type:
mice
Citation Extract:
Hammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI. Antibody-oligonucleotide conjugate achieves central nervous system delivery in animal models for spinal muscular atrophy. JCI Insight. 2022 Nov 8:e154142. doi: 10.1172/jci.insight.154142. Online ahead of print.

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR

Authors:
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, Owens NDL, Khokha MK
Citation:
Nat Commun. 2022 Nov 5;13(1):6681. doi: 10.1038/s41467-022-34363-w
Epub:
Not Epub
Abstract:
Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic development and adult tissue...
Link:
https://www.nature.com/articles/s41467-022-34363-w
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, Owens NDL, Khokha MK. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nat Commun. 2022 Nov 5;13(1):6681. doi: 10.1038/s41467-022-34363-w.

Awakening adult neural stem cells: NOX signalling as a positive regulator of quiescence to proliferation transition in the Xenopus retina

Authors:
Donval A, Puente CVH, Lainé A, Roman D, Vessely R, Leclercq J, Perron M, Locker M
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.06.515333
Epub:
Not Epub
Abstract:
Reactive oxygen species (ROS) are both harmful molecules sustaining the pathogenesis of several diseases and essential...
Link:
https://www.biorxiv.org/content/10.1101/2022.11.06.515333v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Donval A, Puente CVH, Lainé A, Roman D, Vessely R, Leclercq J, Perron M, Locker M. Awakening adult neural stem cells: NOX signalling as a positive regulator of quiescence to proliferation transition in the Xenopus retina. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.06.515333.

Mapping the convergence of genes for coronary artery disease onto endothelial cell programs

Authors:
Schnitzler GR, Kang H, Lee-Kim VS, Ma XR, Zeng T, Angom RS, Fang S, Vellarikkal SK, Zhou R, Guo K, Sias-Garcia O, Bloemendal A, Glen Munson, Guckelberger P, Nguyen TH, Bergman DT, Cheng N, Cleary B, Aragam K, Mukhopadhyay D, Lander ES, Finucane HK, Gupta RM, Engreitz JM
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.01.514606
Epub:
Not Epub
Abstract:
Genome-wide association studies (GWAS) have discovered thousands of risk loci for common, complex diseases, each of which could...
Link:
https://www.biorxiv.org/content/10.1101/2022.11.01.514606v1
Organism or Cell Type:
zebrafish
Citation Extract:
Schnitzler GR, Kang H, Lee-Kim VS, Ma XR, Zeng T, Angom RS, Fang S, Vellarikkal SK, Zhou R, Guo K, Sias-Garcia O, Bloemendal A, Glen Munson, Guckelberger P, Nguyen TH, Bergman DT, Cheng N, Cleary B, Aragam K, Mukhopadhyay D, Lander ES, Finucane HK, Gupta RM, Engreitz JM. Mapping the convergence of genes for coronary artery disease onto endothelial cell programs. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.01.514606.

Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis

Authors:
Rosa JB, Nassman KY, Sagasti A
Citation:
Mol Biol Cell. 2022;[Epub ahead of print] doi:10.1091/mbc.E22-09-0396
Epub:
Not Epub
Abstract:
Epithelial cell properties are determined by the polarized distribution of membrane lipids, the cytoskeleton, and adhesive...
Link:
https://www.molbiolcell.org/doi/10.1091/mbc.E22-09-0396
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rosa JB, Nassman KY, Sagasti A. Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis. Mol Biol Cell. 2022;[Epub ahead of print] doi:10.1091/mbc.E22-09-0396.

Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo

Authors:
Truszkowski L, Batur D, Long H, Tarbashevich K, Vos BE, Trappmann B, Raz E
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.02.514858
Epub:
Not Epub
Abstract:
In both physiological processes and disease contexts, migrating cells have the ability to adapt to conditions in their...
Link:
https://www.biorxiv.org/content/10.1101/2022.11.02.514858v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Truszkowski L, Batur D, Long H, Tarbashevich K, Vos BE, Trappmann B, Raz E. Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.02.514858.

Rab8-, Rab11-, and Rab35-dependent mechanisms coordinating lumen and cilia formation during Left-Right Organizer development

Authors:
Aljiboury AA, Ingram E, Krishnan N, Ononiwu F, Pal D, Manikas J, Taveras C, Hall NA, Da Silva J, Freshour J, Hehnly H
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.10.31.514532
Epub:
Not Epub
Abstract:
An essential process for cilia formation during epithelialization is the movement of the centrosome to dock with the cell’s...
Link:
https://www.biorxiv.org/content/10.1101/2022.10.31.514532v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Aljiboury AA, Ingram E, Krishnan N, Ononiwu F, Pal D, Manikas J, Taveras C, Hall NA, Da Silva J, Freshour J, Hehnly H. Rab8-, Rab11-, and Rab35-dependent mechanisms coordinating lumen and cilia formation during Left-Right Organizer development. bioRxiv. 2022;[preprint] doi:10.1101/2022.10.31.514532.

Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS

Authors:
Seo Y, Mo S, Kim S, Kim H, Park H-C
Citation:
Int J Mol Sci. 2022. 23:13395. doi:10.3390/ijms232113395
Epub:
Not Epub
Abstract:
Tamalin is a post-synaptic scaffolding protein that interacts with group 1 metabotropic glutamate receptors (mGluRs) and...
Link:
https://www.mdpi.com/1422-0067/23/21/13395/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Seo Y, Mo S, Kim S, Kim H, Park H-C. Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS. Int J Mol Sci. 2022. 23:13395. doi:10.3390/ijms232113395.

Homologous gene regulatory networks control development of apical organs and brains in Bilateria

Authors:
Feuda R, Peter IS
Citation:
Sci Adv. 2022 Nov 4;8(44):eabo2416. doi: 10.1126/sciadv.abo2416. Epub 2022 Nov 2
Epub:
Not Epub
Abstract:
Apical organs are relatively simple larval nervous systems. The extent to which apical organs are evolutionarily related to the...
Link:
https://www.science.org/doi/10.1126/sciadv.abo2416
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Feuda R, Peter IS. Homologous gene regulatory networks control development of apical organs and brains in Bilateria. Sci Adv. 2022 Nov 4;8(44):eabo2416. doi: 10.1126/sciadv.abo2416. Epub 2022 Nov 2.

Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands

Authors:
Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW
Citation:
Dev Biol. 2022 Nov 2:S0012-1606(22)00202-0. doi: 10.1016/j.ydbio.2022.10.013. Online ahead of print
Epub:
Not Epub
Abstract:
Wnt11 family proteins are ligands that activate a type of Dishevelled-mediated, non-canonical Wnt signaling pathway. Loss of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160622002020
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW. Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Dev Biol. 2022 Nov 2:S0012-1606(22)00202-0. doi: 10.1016/j.ydbio.2022.10.013. Online ahead of print.

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