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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Modulation of PKM1/2 levels by steric blocking morpholinos alters the metabolic and pluripotent state of murine pluripotent stem cells

Authors:
Dierolf JG, Hunter HLM, Watson AJ, Betts DH
Citation:
Stem Cells Dev. 2022 Apr 25. doi: 10.1089/scd.2021.0347. Online ahead of print
Epub:
Not Epub
Abstract:
Cellular metabolism plays both an active and passive role in embryonic development, pluripotency, and cell-fate decisions....
Link:
https://www.liebertpub.com/doi/10.1089/scd.2021.0347
Delivery Method:
cell culture: murine embryonic stem cells
Citation Extract:
Dierolf JG, Hunter HLM, Watson AJ, Betts DH. Modulation of PKM1/2 levels by steric blocking morpholinos alters the metabolic and pluripotent state of murine pluripotent stem cells. Stem Cells Dev. 2022 Apr 25. doi: 10.1089/scd.2021.0347. Online ahead of print.

"Two-story building" of a ctenophore comb plate provides structural and functional integrity for motility of giant multicilia

Authors:
Jokura K, Sato Y, Shiba K, Inaba K
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.03.27.486007
Epub:
Not Epub
Abstract:
Comb plates (CPs) are large compound cilia uniquely seen in a basal metazoan group of ctenophores. Tens of thousands of cilia...
Link:
https://www.biorxiv.org/content/10.1101/2022.03.27.486007v1
Delivery Method:
microinjection
Organism or Cell Type:
Bolinopsis mikado (ctenophore)
Citation Extract:
Jokura K, Sato Y, Shiba K, Inaba K. "Two-story building" of a ctenophore comb plate provides structural and functional integrity for motility of giant multicilia. bioRxiv. 2022;[preprint] doi:10.1101/2022.03.27.486007 .

STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia

Authors:
Dinarello A, Betto RM, Diamante L, Cioccarelli C, Meneghetti G, Peron M, Tesoriere A, Laquatra C, Tiso N, Martello G, Argenton F
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.11.19.469257
Epub:
Not Epub
Abstract:
STAT3 and HIF1α are two fundamental transcription factors involved in many merging processes, like angiogenesis, metabolism,...
Link:
https://www.biorxiv.org/content/10.1101/2021.11.19.469257v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dinarello A, Betto RM, Diamante L, Cioccarelli C, Meneghetti G, Peron M, Tesoriere A, Laquatra C, Tiso N, Martello G, Argenton F. STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia. bioRxiv. 2021;[preprint] doi:10.1101/2021.11.19.469257.

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality

Authors:
Wattrus SJ, Smith ML, Rodrigues CP, Hagedorn EJ, Budnik B, Zon LI
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.03.07.483327
Epub:
Not Epub
Abstract:
Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis or transform to initiate cancer...
Link:
https://www.biorxiv.org/content/10.1101/2022.03.07.483327v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wattrus SJ, Smith ML, Rodrigues CP, Hagedorn EJ, Budnik B, Zon LI. Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. bioRxiv. 2022;[preprint] doi:10.1101/2022.03.07.483327.

Cell Clusters Containing Intestinal Stem Cells Line the Zebrafish Intestine Intervillus Pocket

Authors:
Tavakoli S, Zhu S, Matsudaira P
Citation:
iScience. 2022;104280 [Epub]. doi:10.1016/j.isci.2022.104280
Epub:
Yes
Abstract:
In the mammalian intestine, stem cells (ISCs) replicate in basal crypts, translocate along the villus, and undergo cell death....
Link:
https://www.sciencedirect.com/science/article/pii/S2589004222005508
Delivery Method:
Vivo-Morphoino intestinal gavage
Organism or Cell Type:
zebrafish
Citation Extract:
Tavakoli S, Zhu S, Matsudaira P. Cell Clusters Containing Intestinal Stem Cells Line the Zebrafish Intestine Intervillus Pocket. iScience. 2022;104280 [Epub]. doi:10.1016/j.isci.2022.104280.

VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway

Authors:
de Sousa E, Móvio MI, de Lima-Vasconcellos TH, Dos Santos GB, Dos Santos Gomes T, Walter LT, da Silva DA, Rodrigues T, Cerchiaro G, Kihara AH
Citation:
Cell Death Dis. 2022 Apr 21;13(4):393. doi: 10.1038/s41419-022-04755-3
Epub:
Not Epub
Abstract:
The voltage-dependent anion channel 1 (VDAC1) was first described as a mitochondrial porin that mediates the flux of...
Link:
https://www.nature.com/articles/s41419-022-04755-3
Delivery Method:
subretinal injection
Organism or Cell Type:
male and female Long Evans rats (Rattus norvegicus)
Citation Extract:
de Sousa E, Móvio MI, de Lima-Vasconcellos TH, Dos Santos GB, Dos Santos Gomes T, Walter LT, da Silva DA, Rodrigues T, Cerchiaro G, Kihara AH. VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway. Cell Death Dis. 2022 Apr 21;13(4):393. doi: 10.1038/s41419-022-04755-3.

The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio

Authors:
Holm A, Possovre M-L, Bandarabadi M, Moseholm KF, Justinussen JL, Bozic I, Lemcke R, Arribat Y, Amati F, Silahtaroglu A, Juventin M, Adamantidis A, Tafti M, Kornum BR
Citation:
Proc Nat Acad Sci USA. 2022;117(17):e2112225119 [Epub] doi:10.1073/pnas.2112225119
Epub:
Not Epub
Abstract:
Hypocretin (Hcrt), also known as orexin, neuropeptide signaling stabilizes sleep and wakefulness in all vertebrates. A lack of...
Link:
https://www.pnas.org/doi/10.1073/pnas.2112225119
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Holm A, Possovre M-L, Bandarabadi M, Moseholm KF, Justinussen JL, Bozic I, Lemcke R, Arribat Y, Amati F, Silahtaroglu A, Juventin M, Adamantidis A, Tafti M, Kornum BR. The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio. Proc Nat Acad Sci USA. 2022;117(17):e2112225119 [Epub] doi:10.1073/pnas.2112225119.

Therapeutic Potential of CKD-504, a Novel Selective Histone Deacetylase 6 Inhibitor, in a Zebrafish Model of Neuromuscular Junction Disorders

Authors:
Jeong HS, Kim HJ, Kim D-H, Chung KW, Choi B-O, Lee JE
Citation:
Mol Cells. 2022;45(4):231-42. doi:10.14348/molcells.2022.5005
Epub:
Not Epub
Abstract:
The neuromuscular junction (NMJ), which is a synapse for signal transmission from motor neurons to muscle cells, has emerged as...
Link:
https://www.molcells.org/journal/view.html
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jeong HS, Kim HJ, Kim D-H, Chung KW, Choi B-O, Lee JE. Therapeutic Potential of CKD-504, a Novel Selective Histone Deacetylase 6 Inhibitor, in a Zebrafish Model of Neuromuscular Junction Disorders. Mol Cells. 2022;45(4):231-42. doi:10.14348/molcells.2022.5005.

Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions

Authors:
Fernandez-Nicolas A, Uchida A, Poon J, Yajima M
Citation:
Nat Commun. 2022 Apr 20;13(1):2145. doi: 10.1038/s41467-022-29855-8
Epub:
Not Epub
Abstract:
mRNA translation on the spindle is hypothesized to be an essential strategy for the localized production of cell regulators....
Link:
https://www.nature.com/articles/s41467-022-29855-8
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Fernandez-Nicolas A, Uchida A, Poon J, Yajima M. Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions. Nat Commun. 2022 Apr 20;13(1):2145. doi: 10.1038/s41467-022-29855-8.

Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis

Authors:
Tournière O, Gahan JM, Busengdal H, Bartsch N, Rentzsch F
Citation:
Sci Adv. 2022 Apr 22;8(16):eabi7109. doi:10.1126/sciadv.abi7109. Epub 2022 Apr 20
Epub:
Not Epub
Abstract:
Neurons are highly specialized cells present in nearly all animals, but their evolutionary origin and relationship to other...
Link:
https://www.science.org/doi/10.1126/sciadv.abi7109
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Tournière O, Gahan JM, Busengdal H, Bartsch N, Rentzsch F. Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis. Sci Adv. 2022 Apr 22;8(16):eabi7109. doi:10.1126/sciadv.abi7109. Epub 2022 Apr 20.

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