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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis

Authors:
Wang D, Tanaka-Yano M, Meader E, Kinney MA, Morris V, Lummertz da Rocha E, Liu N, Liu T, Zhu Q, Orkin SH, North TE, Daley GQ, Rowe RG
Citation:
Cell Rep. 2022 Apr 5;39(1):110587. doi:10.1016/j.celrep.2022.110587
Epub:
Not Epub
Abstract:
Hematopoiesis changes over life to meet the demands of maturation and aging. Here, we find that the definitive hematopoietic...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00331-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang D, Tanaka-Yano M, Meader E, Kinney MA, Morris V, Lummertz da Rocha E, Liu N, Liu T, Zhu Q, Orkin SH, North TE, Daley GQ, Rowe RG. Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis. Cell Rep. 2022 Apr 5;39(1):110587. doi:10.1016/j.celrep.2022.110587.

Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro

Authors:
Flynn LL, Li R, Pitout IL, Aung-Htut MT, Larcher LM, Cooper JAL, Greer KL, Hubbard A, Griffiths L, Bond CS, Wilton SD, Fox AH, Fletcher S
Citation:
Front Genet. 2022;13:791416. doi:10.3389/fgene.2022.791416
Epub:
Not Epub
Abstract:
Oligonucleotides and nucleic acid analogues that alter gene expression are now showing therapeutic promise in human disease....
Link:
https://www.frontiersin.org/articles/10.3389/fgene.2022.791416/full
Delivery Method:
cell bathing or electroporation or Morpholino-DNA heteroduplexes with lipofectamine
Organism or Cell Type:
cell culture: fibroblasts, U2OS
Citation Extract:
Flynn LL, Li R, Pitout IL, Aung-Htut MT, Larcher LM, Cooper JAL, Greer KL, Hubbard A, Griffiths L, Bond CS, Wilton SD, Fox AH, Fletcher S. Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro. Front Genet. 2022;13:791416. doi:10.3389/fgene.2022.791416.

Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

Authors:
Babu S, Takeuchi Y, Masai I
Citation:
bioRXiv. 2021;[preprint] 10.1101/2021.11.03.467208
Epub:
Not Epub
Abstract:
Btg3-associated nuclear protein (Banp) was originally identified as a nuclear matrix- associated region (MAR)-binding protein...
Link:
https://www.biorxiv.org/content/10.1101/2021.11.03.467208v2.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Babu S, Takeuchi Y, Masai I. Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. bioRXiv. 2021;[preprint] 10.1101/2021.11.03.467208.

Innervation modulates the functional connectivity between pancreatic endocrine cells

Authors:
Yang YSC, Briant LJB, Raab CA, Mullapudi ST, Maischein H-M, Kawakami K, Stainier DYR
Citation:
eLife. 2022;11:e64526 doi:10.7554/eLife.64526
Epub:
Not Epub
Abstract:
The importance of pancreatic endocrine cell activity modulation by autonomic innervation has been debated. To investigate this...
Link:
https://elifesciences.org/articles/64526
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang YSC, Briant LJB, Raab CA, Mullapudi ST, Maischein H-M, Kawakami K, Stainier DYR. Innervation modulates the functional connectivity between pancreatic endocrine cells. eLife. 2022;11:e64526 doi:10.7554/eLife.64526.

Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish

Authors:
Zheng YQ, Suo GH, Liu D, Li HY, Wu YJ, Ni H
Citation:
Front Mol Neurosci. 2022 Mar 31;15:848257. doi: 10.3389/fnmol.2022.848257. eCollection 2022
Epub:
Not Epub
Abstract:
Nexmif is mainly expressed in the central nervous system (CNS) and plays important roles in cell migration, cell to cell and...
Link:
https://www.frontiersin.org/articles/10.3389/fnmol.2022.848257/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng YQ, Suo GH, Liu D, Li HY, Wu YJ, Ni H. Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Front Mol Neurosci. 2022 Mar 31;15:848257. doi: 10.3389/fnmol.2022.848257. eCollection 2022.

DSCAM is differentially patterned along the optic axon pathway in the developing Xenopus visual system and guides axon termination at the target

Authors:
Santos RA, Del Rio R Jr, Alvarez AD, Romero G, Vo BZ, Cohen-Cory S
Citation:
Neural Dev. 2022 Apr 15;17(1):5. doi: 10.1186/s13064-022-00161-9
Epub:
Not Epub
Abstract:
Background: The Xenopus retinotectal circuit is organized topographically, where the dorsal-ventral axis of the retina maps...
Link:
https://neuraldevelopment.biomedcentral.com/articles/10.1186/s13064-022-00161-9
Delivery Method:
injection then electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Santos RA, Del Rio R Jr, Alvarez AD, Romero G, Vo BZ, Cohen-Cory S. DSCAM is differentially patterned along the optic axon pathway in the developing Xenopus visual system and guides axon termination at the target. Neural Dev. 2022 Apr 15;17(1):5. doi: 10.1186/s13064-022-00161-9.

RNF152 negatively regulates Wnt/β-catenin signaling in Xenopus embryos

Authors:
Yoon GH, Kim K, Park DS, Choi SC
Citation:
BMB Rep. 2022 Apr 12:5534. Online ahead of print
Epub:
Yes
Abstract:
The Wnt/β-catenin signaling plays crucial roles in early development, tissue homeostasis, stem cells, and cancers. Here, we...
Link:
https://pubmed.ncbi.nlm.nih.gov/35410636/
Organism or Cell Type:
Xenopus
Citation Extract:
Yoon GH, Kim K, Park DS, Choi SC. RNF152 negatively regulates Wnt/β-catenin signaling in Xenopus embryos. BMB Rep. 2022 Apr 12:5534. Online ahead of print.

Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of SMN2 in SMA Type I Fibroblasts

Authors:
Toosaranont J, Ruschadaariyachat S, Mujchariyakul W, Arora JK, Charoensawan V, Suktitipat B, Palmer TN, Fletcher S, Wilton SD, Mitrpant C
Citation:
Int J Mol Sci. 2022 Apr 1;23(7):3937. doi: 10.3390/ijms23073937
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is a severe, debilitating neuromuscular condition characterised by loss of motor neurons and...
Link:
https://www.mdpi.com/1422-0067/23/7/3937/htm
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: human SMA fibroblasts
Citation Extract:
Toosaranont J, Ruschadaariyachat S, Mujchariyakul W, Arora JK, Charoensawan V, Suktitipat B, Palmer TN, Fletcher S, Wilton SD, Mitrpant C. Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of SMN2 in SMA Type I Fibroblasts. Int J Mol Sci. 2022 Apr 1;23(7):3937. doi: 10.3390/ijms23073937.

MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development

Authors:
Sheng J, Gong J, Shi Y, Wang X, Liu D
Citation:
Open Biol. 2022 Apr;12(4):210315. doi: 10.1098/rsob.210315. Epub 2022 Apr 6
Epub:
Not Epub
Abstract:
A precise guiding signal is crucial to orchestrate directional migration and patterning of the complex vascular network and...
Link:
https://royalsocietypublishing.org/doi/10.1098/rsob.210315
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sheng J, Gong J, Shi Y, Wang X, Liu D. MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development. Open Biol. 2022 Apr;12(4):210315. doi: 10.1098/rsob.210315. Epub 2022 Apr 6.

Cardio-respiratory and phenotypic rescue of dystrophin/utrophin-deficient mice by combination therapy

Authors:
Lin C, Han G, Jia L, Zhao Y, Song J, Ran N, Yokota T, Seow Y, Yin H
Citation:
EMBO Rep. 2022 Apr 8:e53955. doi: 10.15252/embr.202153955. Online ahead of print
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is a systemic progressive muscular disease caused by frame-disrupting mutations in the DMD...
Link:
https://www.embopress.org/doi/abs/10.15252/embr.202153955
Delivery Method:
i.v. injection
Organism or Cell Type:
dystrophin/utrophin double knock-out (DKO) mice
Citation Extract:
Lin C, Han G, Jia L, Zhao Y, Song J, Ran N, Yokota T, Seow Y, Yin H. Cardio-respiratory and phenotypic rescue of dystrophin/utrophin-deficient mice by combination therapy. EMBO Rep. 2022 Apr 8:e53955. doi: 10.15252/embr.202153955. Online ahead of print.

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