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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model

Authors:
Zheng S, Tang D, Wang X, Liu C, Zuo N, Yan R, Wu C, Ma J, Wang C, Xu H, He Y, Liu D, Liu S
Citation:
Front Mol Neurosci. 2022;15:844568. doi:10.3389/fnmol.2022.844568
Epub:
Not Epub
Abstract:
Kif15, a kinesin family member, is powerful in the formation of bipolar spindles. There is emerging evidence indicating that...
Link:
https://www.frontiersin.org/articles/10.3389/fnmol.2022.844568/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng S, Tang D, Wang X, Liu C, Zuo N, Yan R, Wu C, Ma J, Wang C, Xu H, He Y, Liu D, Liu S. Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model. Front Mol Neurosci. 2022;15:844568. doi:10.3389/fnmol.2022.844568.

Splicing is an alternate oncogenic pathway activation mechanism in glioma

Authors:
Siddaway R, Milos S, Vadivel AKA, Dobson THW, Swaminathan J, Ryall S, Pajovic S, Patel PG, Nazarian J, Becher O, Brudno M, Ramani A, Gopalakrishnan V, Hawkins C
Citation:
Nat Commun. 2022 Jan 31;13(1):588. doi: 10.1038/s41467-022-28253-4
Epub:
Not Epub
Abstract:
High-grade diffuse glioma (HGG) is the leading cause of brain tumour death. While the genetic drivers of HGG have been well...
Link:
https://www.nature.com/articles/s41467-022-28253-4
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: U87 GBM, pediatric and adult HGG cells
Citation Extract:
Siddaway R, Milos S, Vadivel AKA, Dobson THW, Swaminathan J, Ryall S, Pajovic S, Patel PG, Nazarian J, Becher O, Brudno M, Ramani A, Gopalakrishnan V, Hawkins C. Splicing is an alternate oncogenic pathway activation mechanism in glioma. Nat Commun. 2022 Jan 31;13(1):588. doi: 10.1038/s41467-022-28253-4.

The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

Authors:
Hage A, Bharaj P, van Tol S, Giraldo MI, Gonzalez-Orozco M, Valerdi KM, Warren AN, Aguilera-Aguirre L, Xie X, Widen SG, Moulton HM, Lee B, Johnson JR, Krogan NJ, García-Sastre A, Shi PY, Freiberg AN, Rajsbaum R
Citation:
Cell Rep. 2022 Mar 8;38(10):110434. doi: 10.1016/j.celrep.2022.110434
Epub:
Not Epub
Abstract:
Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub)...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00161-9
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
C57BL/6 or BALB/c mice
Citation Extract:
Hage A, Bharaj P, van Tol S, Giraldo MI, Gonzalez-Orozco M, Valerdi KM, Warren AN, Aguilera-Aguirre L, Xie X, Widen SG, Moulton HM, Lee B, Johnson JR, Krogan NJ, García-Sastre A, Shi PY, Freiberg AN, Rajsbaum R. The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity. Cell Rep. 2022 Mar 8;38(10):110434. doi: 10.1016/j.celrep.2022.110434.

MYPT1/PP1-Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial-Mesenchymal Transition in Fibrosis through Control of Multiple Families of Genes

Authors:
Zhang L, Wang L, Hu X-B, Hou M, Xiao Y, Xiang J-W, Xie J, Chen Z-G, Yang T-H, Nie Q, Fu J-L, Wang Y, Zheng S-Y, Liu Y-F, Gan Y-W, Gao Q, Bai Y-Y, Wang J-M, Qi R-L, Zou M, Ke Q, Zhu X-F, Gong L, Liu Y, Li DW-C
Citation:
Adv Sci. 2022;21o5539 doi:10.1002/advs.20210553
Epub:
Not Epub
Abstract:
The methyltransferase EZH2 plays an important role in regulating chromatin conformation and gene transcription. Phosphorylation...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202105539
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang L, Wang L, Hu X-B, Hou M, Xiao Y, Xiang J-W, Xie J, Chen Z-G, Yang T-H, Nie Q, Fu J-L, Wang Y, Zheng S-Y, Liu Y-F, Gan Y-W, Gao Q, Bai Y-Y, Wang J-M, Qi R-L, Zou M, Ke Q, Zhu X-F, Gong L, Liu Y, Li DW-C. MYPT1/PP1-Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial-Mesenchymal Transition in Fibrosis through Control of Multiple Families of Genes. Adv Sci. 2022;21o5539 doi:10.1002/advs.20210553.

Quantitative Analysis of Transcriptome Dynamics Provides Novel Insights into Developmental State Transitions

Authors:
Johnson K, Freedman S, Braun R, LaBonne C
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.03.10.483850
Epub:
Not Epub
Abstract:
During embryogenesis, the developmental potential of initially pluripotent cells becomes progressively restricted as they...
Link:
https://www.biorxiv.org/content/10.1101/2022.03.10.483850v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Johnson K, Freedman S, Braun R, LaBonne C. Quantitative Analysis of Transcriptome Dynamics Provides Novel Insights into Developmental State Transitions. bioRxiv. 2022;[preprint] doi:10.1101/2022.03.10.483850.

Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis

Authors:
Vignes H, Vagena-Pantoula C, Prakash M, Fukui H, Norden C, Mochizuki N, Jug F, Vermot J
Citation:
Dev Cell. 2022 Feb 28:S1534-5807(22)00077-6. doi:10.1016/j.devcel.2022.02.011. Online ahead of print
Epub:
Yes
Abstract:
Organ morphogenesis involves dynamic changes of tissue properties while cells adapt to their mechanical environment through...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580722001034
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vignes H, Vagena-Pantoula C, Prakash M, Fukui H, Norden C, Mochizuki N, Jug F, Vermot J. Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis. Dev Cell. 2022 Feb 28:S1534-5807(22)00077-6. doi:10.1016/j.devcel.2022.02.011. Online ahead of print.

Targeted exon skipping of NF1 exon 17 as a Therapeutic for Neurofibromatosis Type I

Authors:
Leier A, Moore M, Liu H, Daniel M, Hyde AM, Messiaen L, Korf BR, Selvakumaran J, Ciszewski L, Lambert L, Foote J, Wallace MR, Kesterson RA, Dickson G, Popplewell L, Wallis D
Citation:
Mol Ther Nucleic Acids. 2022;[Epub] doi:10.1016/j.omtn.2022.03.011
Epub:
Not Epub
Abstract:
We investigated the feasibility of utilizing an exon skipping approach as a genotype-dependent therapeutic for...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(22)00060-9
Delivery Method:
Endo-Porter DMSO
Organism or Cell Type:
cell culture: human lines with NF1 e17 mutations
Citation Extract:
Leier A, Moore M, Liu H, Daniel M, Hyde AM, Messiaen L, Korf BR, Selvakumaran J, Ciszewski L, Lambert L, Foote J, Wallace MR, Kesterson RA, Dickson G, Popplewell L, Wallis D. Targeted exon skipping of NF1 exon 17 as a Therapeutic for Neurofibromatosis Type I. Mol Ther Nucleic Acids. 2022;[Epub] doi:10.1016/j.omtn.2022.03.011.

Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes

Authors:
Lv X, Zhang R, Xu L, Wang G, Yan C, Lin P
Citation:
Front Cell Dev Biol. 2022;10:836464. doi:10.3389/fcell.2022.836464
Epub:
Not Epub
Abstract:
Limb-girdle muscular dystrophy 2G (LGMD2G) is a subtype of limb-girdle muscular dystrophy. However, the disease’s mechanisms...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2022.836464/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lv X, Zhang R, Xu L, Wang G, Yan C, Lin P. Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes. Front Cell Dev Biol. 2022;10:836464. doi:10.3389/fcell.2022.836464.

Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly

Authors:
Gur M, Bendelac-Kapon L, Shabtai Y, Pillemer G, Fainsod A
Citation:
Front Cell Dev Biol. 2022;10:844619. doi:10.3389/fcell.2022.844619
Epub:
Not Epub
Abstract:
Retinoic acid (RA) is a central signaling molecule regulating multiple developmental decisions during embryogenesis. Excess RA...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2022.844619/full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gur M, Bendelac-Kapon L, Shabtai Y, Pillemer G, Fainsod A. Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly. Front Cell Dev Biol. 2022;10:844619. doi:10.3389/fcell.2022.844619.

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder

Authors:
Laghi V, Rezelj V, Boucontet L, Frétaud M, Da Costa B, Boudinot P, Salinas I, Lutfalla G, Vignuzzi M, Levraud J-P
Citation:
Front Cell Infect Microbiol. 2022;12:790851. doi:10.3389/fcimb.2022.790851
Epub:
Not Epub
Abstract:
Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other...
Link:
https://www.frontiersin.org/articles/10.3389/fcimb.2022.790851/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Laghi V, Rezelj V, Boucontet L, Frétaud M, Da Costa B, Boudinot P, Salinas I, Lutfalla G, Vignuzzi M, Levraud J-P. Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder. Front Cell Infect Microbiol. 2022;12:790851. doi:10.3389/fcimb.2022.790851.

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