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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12179 scientific papers returned from the database with the search filters currently being used below.

Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation

Authors:
Maglitto A, Mariani SA, de Pater E, Rodriguez-Seoane C, Vink CS, Piao X, Lukke M-L, Dzierzak E
Citation:
Blood Adv. 2021;5(3):829–842. doi:10.1182/bloodadvances.2020003693
Epub:
Not Epub
Abstract:
Integrated molecular signals regulate cell fate decisions in the embryonic aortic endothelium to drive hematopoietic stem cell...
Link:
https://ashpublications.org/bloodadvances/article/5/3/829/475137/Unexpected-redundancy-of-Gpr56-and-Gpr97-during
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Maglitto A, Mariani SA, de Pater E, Rodriguez-Seoane C, Vink CS, Piao X, Lukke M-L, Dzierzak E. Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. Blood Adv. 2021;5(3):829–842. doi:10.1182/bloodadvances.2020003693.

The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development

Authors:
Erdogan B, Cammarata GM, Lee EJ, Pratt BC, Francl AF, Rutherford EL, Lowery LA
Citation:
Neural Dev. 2017 Feb 15;12(1):3. doi: 10.1186/s13064-017-0080-7. PMID: 28202041; PMCID: PMC5312526
Epub:
Not Epub
Abstract:
Background: Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone...
Link:
https://link.springer.com/article/10.1186/s13064-017-0080-7
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Erdogan B, Cammarata GM, Lee EJ, Pratt BC, Francl AF, Rutherford EL, Lowery LA. The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development. Neural Dev. 2017 Feb 15;12(1):3. doi: 10.1186/s13064-017-0080-7. PMID: 28202041; PMCID: PMC5312526.

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Authors:
Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDC, Gaulton KJ, Sander M
Citation:
eLife. 2021;10:e59067 doi:10.7554/eLife.59067
Epub:
Not Epub
Abstract:
Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as...
Link:
https://elifesciences.org/articles/59067
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDC, Gaulton KJ, Sander M. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. eLife. 2021;10:e59067 doi:10.7554/eLife.59067.

l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain

Authors:
Soliman R, Cordero-Maldonado ML, Martins TG, Moein M, Conrotte JF, Warmack RA, Skupin A, Crawford AD, Clarke SG, Linster CL
Citation:
Front Genet. 2021 Jan 21;11:612343. doi: 10.3389/fgene.2020.612343. eCollection 2020
Epub:
Not Epub
Abstract:
Isomerization of l-aspartyl and l-asparaginyl residues to l-isoaspartyl residues is one type of protein damage that can occur...
Link:
https://www.frontiersin.org/articles/10.3389/fgene.2020.612343/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Soliman R, Cordero-Maldonado ML, Martins TG, Moein M, Conrotte JF, Warmack RA, Skupin A, Crawford AD, Clarke SG, Linster CL. l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain. Front Genet. 2021 Jan 21;11:612343. doi: 10.3389/fgene.2020.612343. eCollection 2020.

Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

Authors:
Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AGL, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S
Citation:
Nat Commun. 2021 Feb 5;12(1):833. doi: 10.1038/s41467-021-21053-2
Epub:
Not Epub
Abstract:
The structure of proline prevents it from adopting an optimal position for rapid protein synthesis. Poly-proline-tract (PPT)...
Link:
https://www.nature.com/articles/s41467-021-21053-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AGL, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S. Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine. Nat Commun. 2021 Feb 5;12(1):833. doi: 10.1038/s41467-021-21053-2.

Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk

Authors:
Bastos de Oliveira M, Meier K, Jung S, Bartels-Klein E, Coxam B, Geudens I, Szymborska A, Skoczylas R, Fechner I, Koltowska K, Gerhardt H
Citation:
Development. 2021 Feb 5:dev.194993. doi: 10.1242/dev.194993. Online ahead of print
Epub:
Not Epub
Abstract:
Previous studies have shown that Vasohibin-1 (Vash1) is stimulated by VEGFs in endothelial cells and that its overexpression...
Link:
https://dev.biologists.org/content/early/2021/02/04/dev.194993
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bastos de Oliveira M, Meier K, Jung S, Bartels-Klein E, Coxam B, Geudens I, Szymborska A, Skoczylas R, Fechner I, Koltowska K, Gerhardt H. Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. Development. 2021 Feb 5:dev.194993. doi: 10.1242/dev.194993. Online ahead of print.

SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa

Authors:
Zhang T, Bai J, Zhang X, Zheng X, Lu N, Liang Z, Lin L, Chen Y
Citation:
Front Med (Lausanne). 2021 Jan 21;7:588991. doi: 10.3389/fmed.2020.588991
Epub:
Not Epub
Abstract:
The small nuclear ribonucleoprotein 200 kDa (SNRNP200) gene plays a key role in the maturation of pre-message RNA (pre-mRNA)...
Link:
https://www.frontiersin.org/articles/10.3389/fmed.2020.588991/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang T, Bai J, Zhang X, Zheng X, Lu N, Liang Z, Lin L, Chen Y. SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa. Front Med (Lausanne). 2021 Jan 21;7:588991. doi: 10.3389/fmed.2020.588991.

Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy

Authors:
Wrighton PJ, Shwartz A, Heo J-M, Quenzer ED, LaBella KA, Harper JW, Goessling W
Citation:
J Cell Sci. 2021;[Epub ahead of print] doi:10.1242/jcs.256255
Epub:
Yes
Abstract:
Mitophagy, the selective recycling of mitochondria through autophagy, is a crucial metabolic process induced by cellular stress...
Link:
https://jcs.biologists.org/content/early/2021/02/01/jcs.256255
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wrighton PJ, Shwartz A, Heo J-M, Quenzer ED, LaBella KA, Harper JW, Goessling W. Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy. J Cell Sci. 2021;[Epub ahead of print] doi:10.1242/jcs.256255.

A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation

Authors:
Campbell CA, Fursova O, Cheng X, Snella E, McCune A, Li L, Solchenberger B, Schmid B, Sahoo D, Morton M, Traver D, Palazon RE
Citation:
Blood Adv. 2021;5(3):796-811. doi:10.1182/bloodadvances.2020003096
Epub:
Not Epub
Abstract:
Granulin is a pleiotropic protein involved in inflammation, wound healing, neurodegenerative disease, and tumorigenesis. These...
Link:
https://ashpublications.org/bloodadvances/article/5/3/796/475091/A-zebrafish-model-of-granulin-deficiency-reveals
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Campbell CA, Fursova O, Cheng X, Snella E, McCune A, Li L, Solchenberger B, Schmid B, Sahoo D, Morton M, Traver D, Palazon RE. A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood Adv. 2021;5(3):796-811. doi:10.1182/bloodadvances.2020003096.

Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish

Authors:
Rattka M, Westphal S, Gahr BM, Just S, Rottbauer W
Citation:
J Mol Cell Cardiol. 2021;[Epub ahead of print] doi:10.1016/j.yjmcc.2021.01.006
Epub:
Yes
Abstract:
Genome-wide association studies identified Spen as a putative modifier of cardiac function, however, the precise function of...
Link:
https://www.jmcc-online.com/article/S0022-2828(21)00022-5/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rattka M, Westphal S, Gahr BM, Just S, Rottbauer W. Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish. J Mol Cell Cardiol. 2021;[Epub ahead of print] doi:10.1016/j.yjmcc.2021.01.006.

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