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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation

Authors:
Maglitto A, Mariani SA, de Pater E, Rodriguez-Seoane C, Vink CS, Piao X, Lukke M-L, Dzierzak E
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.18.303230
Epub:
Not Epub
Abstract:
Integrated molecular signals regulate cell fate during embryonic hematopoietic stem cell (HSC) generation. The G-protein...
Link:
https://www.biorxiv.org/content/10.1101/2020.09.18.303230v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Maglitto A, Mariani SA, de Pater E, Rodriguez-Seoane C, Vink CS, Piao X, Lukke M-L, Dzierzak E. Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.18.303230.

Using the Zebrafish Model to Study T Cell Development

Authors:
Zhang Y, Wiest DL
Citation:
Methods Mol Biol. 2016;1323:273-92. doi: 10.1007/978-1-4939-2809-5_22
Epub:
Not Epub
Abstract:
While zebrafish has for some time been regarded as a powerful model organism with which to study early events in hematopoiesis...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-2809-5_22
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Y, Wiest DL. Using the Zebrafish Model to Study T Cell Development. Methods Mol Biol. 2016;1323:273-92. doi: 10.1007/978-1-4939-2809-5_22.

Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state

Authors:
Helker CS, Eberlein J, Wilhelm K, Sugino T, Malchow J, Schuermann A, Baumeister S, Kwon HB, Maischein HM, Potente M, Herzog W, Stainier DY
Citation:
Elife. 2020 Sep 21;9:e55589. doi: 10.7554/eLife.55589. Online ahead of print
Epub:
Not Epub
Abstract:
To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and acquire highly migratory and...
Link:
https://elifesciences.org/articles/55589
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Helker CS, Eberlein J, Wilhelm K, Sugino T, Malchow J, Schuermann A, Baumeister S, Kwon HB, Maischein HM, Potente M, Herzog W, Stainier DY. Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state. Elife. 2020 Sep 21;9:e55589. doi: 10.7554/eLife.55589. Online ahead of print.

Deletion of morpholino binding sites (DeMOBS) to assess specificity of morphant phenotypes

Authors:
Cunningham CM, Bellipanni G, Habas R, Balciunas D
Citation:
Sci Rep. 2020 Sep 21;10(1):15366. doi: 10.1038/s41598-020-71708-1
Epub:
Not Epub
Abstract:
Two complimentary approaches are widely used to study gene function in zebrafish: induction of genetic mutations, usually using...
Link:
https://www.nature.com/articles/s41598-020-71708-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cunningham CM, Bellipanni G, Habas R, Balciunas D. Deletion of morpholino binding sites (DeMOBS) to assess specificity of morphant phenotypes. Sci Rep. 2020 Sep 21;10(1):15366. doi: 10.1038/s41598-020-71708-1.

Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides

Authors:
Nordin JZ, Mizobe Y, Nakamura H, Komaki H, Takeda S, Aoki Y
Citation:
J Vis Exp. 2020 May 7;(159). doi: 10.3791/60672
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a degenerative muscle disease that causes progressive loss of muscle mass, leading to...
Link:
https://www.jove.com/v/60672/characterizing-exon-skipping-efficiency-dmd-patient-samples-clinical
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Nordin JZ, Mizobe Y, Nakamura H, Komaki H, Takeda S, Aoki Y. Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides. J Vis Exp. 2020 May 7;(159). doi: 10.3791/60672.

Mouse fertilization triggers a conserved transcription program in one-cell embryos

Authors:
Asami M, Lam BYH, Hoffmann M, Suzuki T, Lu X, VerMilyea MD, Yoshida N, Ma MK, Rainbow K, Braun S, Patwary N, Yeo GSH, Klein CA, Perry ACF
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.15.298018
Epub:
Not Epub
Abstract:
Following fertilization, the new embryo reprograms parental genomes to begin transcription (embryonic genome activation, EGA)....
Link:
https://www.biorxiv.org/content/10.1101/2020.09.15.298018v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Asami M, Lam BYH, Hoffmann M, Suzuki T, Lu X, VerMilyea MD, Yoshida N, Ma MK, Rainbow K, Braun S, Patwary N, Yeo GSH, Klein CA, Perry ACF. Mouse fertilization triggers a conserved transcription program in one-cell embryos. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.15.298018 .

Autophagy induction promotes renal cyst growth in polycystic kidney disease

Authors:
Lee EJ, Ko JY, Oh S, Jun J, Mun H, Lim CJ, Seo S, Ko HW, Kim H, Oh YK, Ahn C, Kang M, Kim MJ, Yoo KH, Oh GT, Park JH
Citation:
EBioMedicine. 2020 Sep 16;60:102986. doi: 10.1016/j.ebiom.2020.102986. Online ahead of print
Epub:
Yes
Abstract:
Background: Polycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been...
Link:
https://www.sciencedirect.com/science/article/pii/S2352396420303625
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee EJ, Ko JY, Oh S, Jun J, Mun H, Lim CJ, Seo S, Ko HW, Kim H, Oh YK, Ahn C, Kang M, Kim MJ, Yoo KH, Oh GT, Park JH. Autophagy induction promotes renal cyst growth in polycystic kidney disease. EBioMedicine. 2020 Sep 16;60:102986. doi: 10.1016/j.ebiom.2020.102986. Online ahead of print.

Posttranscriptional regulation of maternal Pou5f1/Oct4 during mouse oogenesis and early embryogenesis

Authors:
Takada Y, Iyyappan R, Susor A, Kotani T
Citation:
Histochem Cell Biol. 2020 Sep 15. doi: 10.1007/s00418-020-01915-4. Online ahead of print. PMID: 32930837
Epub:
Yes
Abstract:
Protein syntheses at appropriate timings are important for promoting diverse biological processes and are controlled at the...
Link:
https://link.springer.com/article/10.1007/s00418-020-01915-4
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Takada Y, Iyyappan R, Susor A, Kotani T. Posttranscriptional regulation of maternal Pou5f1/Oct4 during mouse oogenesis and early embryogenesis. Histochem Cell Biol. 2020 Sep 15. doi: 10.1007/s00418-020-01915-4. Online ahead of print. PMID: 32930837 .

Wasp controls oriented migration of endothelial cells to achieve functional vascular patterning

Authors:
Rosa A, Giese W, Meier K, Alt S, Klaus-Bergmann A, Edgar L, Bartels E, Collins R, Szymborska-Mell A, Coxam B, Bernabeu MO, Gerhardt H
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.15.296574
Epub:
Not Epub
Abstract:
Endothelial cell migration and proliferation are essential for the establishment of a hierarchical organization of blood...
Link:
https://www.biorxiv.org/content/10.1101/2020.09.15.296574v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rosa A, Giese W, Meier K, Alt S, Klaus-Bergmann A, Edgar L, Bartels E, Collins R, Szymborska-Mell A, Coxam B, Bernabeu MO, Gerhardt H. Wasp controls oriented migration of endothelial cells to achieve functional vascular patterning. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.15.296574.

Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans

Authors:
Lou B, Boger M, Bennewitz K, Sticht C, Kopf S, Morgenstern J, Fleming T, Hell R, Yuan Z, Nawroth PP, Kroll J
Citation:
Redox Biol. 2020;101723. doi:10.1016/j.redox.2020.101723
Epub:
Not Epub
Abstract:
Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG...
Link:
https://www.sciencedirect.com/science/article/pii/S2213231720309289
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lou B, Boger M, Bennewitz K, Sticht C, Kopf S, Morgenstern J, Fleming T, Hell R, Yuan Z, Nawroth PP, Kroll J. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biol. 2020;101723. doi:10.1016/j.redox.2020.101723.

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