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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Resting cells rely on the DNA helicase component MCM2 to build cilia

Authors:
Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M
Citation:
Nucleic Acids Res. 2018 Oct 17. doi: 10.1093/nar/gky945. [Epub ahead of print]
Epub:
Yes
Abstract:
Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand....
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky945/5133663
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M. Resting cells rely on the DNA helicase component MCM2 to build cilia. Nucleic Acids Res. 2018 Oct 17. doi: 10.1093/nar/gky945. [Epub ahead of print].

EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish

Authors:
Barrodia P, Patra C, Swain RK
Citation:
Cell & Biosci. 2018;8:53. doi:10.1186/s13578-018-0253-z
Epub:
Not Epub
Abstract:
Background: The blood filtering organ in zebrafish embryos is the pronephros, which consists of two functional nephrons....
Link:
https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-018-0253-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Barrodia P, Patra C, Swain RK. EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish. Cell & Biosci. 2018;8:53. doi:10.1186/s13578-018-0253-z.

Identification of novel antisense-mediated exon skipping targets in DYSF for therapeutic treatment of dysferlinopathy

Authors:
Lee JJA, Maruyama R, Duddy W, Sakurai H, Yokota T
Citation:
Molec Ther Nucleic Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.10.004
Epub:
Yes
Abstract:
Dysferlinopathy is a progressive myopathy caused by mutations in the dysferlin (DYSF) gene. Dysferlin protein plays a major...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30275-0
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human fibroblast
Citation Extract:
Lee JJA, Maruyama R, Duddy W, Sakurai H, Yokota T. Identification of novel antisense-mediated exon skipping targets in DYSF for therapeutic treatment of dysferlinopathy. Molec Ther Nucleic Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.10.004.

Shorter Phosphorodiamidate Morpholino Splice-Switching Oligonucleotides may increase Exon Skipping Efficacy in Duchenne Muscular Dystrophy

Authors:
Akpulat U, Wang H, Becker K, Contreras A, Partridge T, Novak J, Cirak S
Citation:
Molec Ther Nucleic Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.10.002
Epub:
Yes
Abstract:
Duchenne muscular dystrophy is a fatal muscle disease, caused by mutations in DMD leading to loss of dystrophin expression....
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30273-7
Delivery Method:
i.m. injection
Organism or Cell Type:
mice mdx52
Citation Extract:
Akpulat U, Wang H, Becker K, Contreras A, Partridge T, Novak J, Cirak S. Shorter Phosphorodiamidate Morpholino Splice-Switching Oligonucleotides may increase Exon Skipping Efficacy in Duchenne Muscular Dystrophy. Molec Ther Nucleic Acids. 2018;[Epub ahead of print] doi:10.1016/j.omtn.2018.10.002.

Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development

Authors:
Tian J, Shao J, Liu C, Hou HY, Chou CW, Shboul M, Li GQ, El-Khateeb M, Samarah OQ, Kou Y, Chen YH, Chen MJ, Lyu Z, Chen WL, Chen YF, Sun YH, Liu YW
Citation:
Cell Mol Life Sci. 2018 Oct 16. doi: 10.1007/s00018-018-2928-3. [Epub ahead of print]
Epub:
Yes
Abstract:
Low-density lipoprotein receptor-related protein 4 (LRP4) is a multi-functional protein implicated in bone, kidney and...
Link:
https://link.springer.com/article/10.1007%2Fs00018-018-2928-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tian J, Shao J, Liu C, Hou HY, Chou CW, Shboul M, Li GQ, El-Khateeb M, Samarah OQ, Kou Y, Chen YH, Chen MJ, Lyu Z, Chen WL, Chen YF, Sun YH, Liu YW. Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development. Cell Mol Life Sci. 2018 Oct 16. doi: 10.1007/s00018-018-2928-3. [Epub ahead of print].

Canonical and non-canonical Wnt signaling pathways define the expression domains of Frizzled 5/8 and Frizzled 1/2/7 along the early anterior-posterior axis in sea urchin embryos

Authors:
Range RC
Citation:
Dev Biol. 2018 Oct 14. pii: S0012-1606(18)30238-0. doi: 10.1016/j.ydbio.2018.10.003. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The spatiotemporal expression of Frizzled receptors is critical for patterning along the early anterior-posterior axis during...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160618302380
Delivery Method:
microinjection
Organism or Cell Type:
sea urchin
Citation Extract:
Range RC. Canonical and non-canonical Wnt signaling pathways define the expression domains of Frizzled 5/8 and Frizzled 1/2/7 along the early anterior-posterior axis in sea urchin embryos. Dev Biol. 2018 Oct 14. pii: S0012-1606(18)30238-0. doi: 10.1016/j.ydbio.2018.10.003. [Epub ahead of print].

Gene Knockdown in Zebrafish (Danio rerio) as a Tool to Model Photoreceptor Diseases

Authors:
Dill H, Fischer U
Citation:
Retinal Degeneration. 2018:209-19. In: Weber B., Langmann T. (eds) Retinal Degeneration. Methods in Molecular Biology, vol 1834. Humana Press, New York, NY. doi:10.1007/978-1-4939-8669-9_15
Epub:
Not Epub
Abstract:
Disturbances in the general mRNA metabolism have been recognized as a major defect in a growing number of hereditary human...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8669-9_15
Organism or Cell Type:
zebrafish
Citation Extract:
Dill H, Fischer U. Gene Knockdown in Zebrafish (Danio rerio) as a Tool to Model Photoreceptor Diseases. Retinal Degeneration. 2018:209-19. In: Weber B., Langmann T. (eds) Retinal Degeneration. Methods in Molecular Biology, vol 1834. Humana Press, New York, NY. doi:10.1007/978-1-4939-8669-9_15.

Both Gfrα1a and 1b are involved in the self-renewal and maintenance of spermatogonial stem cells in medaka

Authors:
Zhao Y, Yang Z, Wang Y, Luo Y, Da F, Tao W, Zhou L, Wang D, Wei J
Citation:
Stem Cells Dev. 2018 Oct 15. doi: 10.1089/scd.2018.0177. [Epub ahead of print]
Epub:
Yes
Abstract:
Glial cell-derived neurotrophic factor family receptor alpha-1 (GFRα1) plays a crucial role in the self-renewal and maintenance...
Link:
https://www.liebertpub.com/doi/abs/10.1089/scd.2018.0177
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Zhao Y, Yang Z, Wang Y, Luo Y, Da F, Tao W, Zhou L, Wang D, Wei J. Both Gfrα1a and 1b are involved in the self-renewal and maintenance of spermatogonial stem cells in medaka. Stem Cells Dev. 2018 Oct 15. doi: 10.1089/scd.2018.0177. [Epub ahead of print].

Roles of end-binding 1 protein and gamma-tubulin small complex in cytokinesis and flagella formation of Giardia lamblia

Authors:
Kim J, Park SJ
Citation:
Microbiologyopen. 2018 Oct 14:e748. doi: 10.1002/mbo3.748. [Epub ahead of print]
Epub:
Yes
Abstract:
Giardia lamblia is a unicellular organism with two nuclei, a median body, eight flagella, and an adhesive disk. γ-Tubulin is a...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/mbo3.748
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Kim J, Park SJ. Roles of end-binding 1 protein and gamma-tubulin small complex in cytokinesis and flagella formation of Giardia lamblia. Microbiologyopen. 2018 Oct 14:e748. doi: 10.1002/mbo3.748. [Epub ahead of print].

Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate

Authors:
Chuykin I, Ossipova O, Sokol SY
Citation:
Elife. 2018 Sep 26;7. pii: e37881. doi: 10.7554/eLife.37881
Epub:
Not Epub
Abstract:
Vertebrate neural tube formation depends on the coordinated orientation of cells in the tissue known as planar cell polarity (...
Link:
https://elifesciences.org/articles/37881
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chuykin I, Ossipova O, Sokol SY. Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate. Elife. 2018 Sep 26;7. pii: e37881. doi: 10.7554/eLife.37881.

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