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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

Authors:
Scerbo P, Marchal L, Kodjabachian L
Citation:
Elife. 2017 Jun 27;6. pii: e21526. doi: 10.7554/eLife.21526
Epub:
Not Epub
Abstract:
During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. How this...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Scerbo P, Marchal L, Kodjabachian L. Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2. Elife. 2017 Jun 27;6. pii: e21526. doi: 10.7554/eLife.21526.

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

Authors:
Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B
Citation:
Nat Commun. 2017 Jun 28;8:15865. doi: 10.1038/ncomms15865
Epub:
Not Epub
Abstract:
Optimal regulation of the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice C57BL/6J
Citation Extract:
Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B. E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. Nat Commun. 2017 Jun 28;8:15865. doi: 10.1038/ncomms15865.

Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection

Authors:
Vincent WJB, Harvie EA, Sauer J-D, Huttenlocher A
Citation:
PLoS ONE. 2017:12(6):e0179574. doi:10.1371/journal.pone.0179574
Epub:
Not Epub
Abstract:
Immune cells sense and react to a multitude of factors including both host and microbe-derived signals. Understanding how cells...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vincent WJB, Harvie EA, Sauer J-D, Huttenlocher A. Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. PLoS ONE. 2017:12(6):e0179574. doi:10.1371/journal.pone.0179574.

Septins restrict inflammation and protect zebrafish larvae from Shigella infection

Authors:
Mazon-Moya MJ, Willis AR, Torraca V, Boucontet L, Shenoy AR, Colucci-Guyon E, Mostowy S
Citation:
PLoS Pathog. 2017;13(6):e1006467. https://doi.org/10.1371/journal.ppat.1006467
Epub:
Not Epub
Abstract:
Shigella flexneri, a Gram-negative enteroinvasive pathogen, causes inflammatory destruction of the human colonic epithelium....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mazon-Moya MJ, Willis AR, Torraca V, Boucontet L, Shenoy AR, Colucci-Guyon E, Mostowy S. Septins restrict inflammation and protect zebrafish larvae from Shigella infection. PLoS Pathog. 2017;13(6):e1006467. https://doi.org/10.1371/journal.ppat.1006467.

Antagonistic BMP-cWNT signaling in the cnidarian Nematostella vectensis reveals insight into the evolution of mesoderm

Authors:
Wijesena N, Simmons DK, Martindale MQ
Citation:
Proc Natl Acad Sci U S A. 2017 Jun 26. pii: 201701607. doi: 10.1073/pnas.1701607114. [Epub ahead of print]
Epub:
Yes
Abstract:
Gastrulation was arguably the key evolutionary innovation that enabled metazoan diversification, leading to the formation of...
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Wijesena N, Simmons DK, Martindale MQ. Antagonistic BMP-cWNT signaling in the cnidarian Nematostella vectensis reveals insight into the evolution of mesoderm. Proc Natl Acad Sci U S A. 2017 Jun 26. pii: 201701607. doi: 10.1073/pnas.1701607114. [Epub ahead of print].

Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation

Authors:
Gallagher TL, Tietz KT, Morrow ZT, McCammon JM, Goldrich ML, Derr NL, Amacher SL
Citation:
Dev Biol. 2017 Jun 22. pii: S0012-1606(17)30265-8. doi: 10.1016/j.ydbio.2017.06.024. [Epub ahead of print]
Epub:
Yes
Abstract:
Vertebrate segmentation is controlled by the segmentation clock, a molecular oscillator that regulates gene expression and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gallagher TL, Tietz KT, Morrow ZT, McCammon JM, Goldrich ML, Derr NL, Amacher SL. Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Dev Biol. 2017 Jun 22. pii: S0012-1606(17)30265-8. doi: 10.1016/j.ydbio.2017.06.024. [Epub ahead of print].

Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation

Authors:
Pünzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, Hake SB
Citation:
EMBO J. 2017 Jun 23. pii: e201695757. doi: 10.15252/embj.201695757. [Epub ahead of print]
Epub:
Yes
Abstract:
Replacement of canonical histones with specialized histone variants promotes altering of chromatin structure and function. The...
Organism or Cell Type:
Xenopus
Citation Extract:
Pünzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, Hake SB. Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. EMBO J. 2017 Jun 23. pii: e201695757. doi: 10.15252/embj.201695757. [Epub ahead of print].

RAPGEF5 regulates nuclear translocation of β-catenin

Authors:
Griffin JN, del Viso F, Duncan AR, Robson A, Kulkarni S, Liu KJ, Khokha MK
Citation:
bioRXiv. 2017. doi:10.1101/152892
Epub:
Not Epub
Abstract:
Canonical Wnt signaling coordinates many critical aspects of embryonic development, while dysregulated Wnt signaling...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Griffin JN, del Viso F, Duncan AR, Robson A, Kulkarni S, Liu KJ, Khokha MK. RAPGEF5 regulates nuclear translocation of β-catenin. bioRXiv. 2017. doi:10.1101/152892.

Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2 dependent pathway

Authors:
Han L, Wang H, Li L, Li X, Ge J, Reiter RJ, Wang Q
Citation:
J Pineal Res. 2017 Jun 28. doi: 10.1111/jpi.12431. [Epub ahead of print]
Epub:
Yes
Abstract:
Maternal obesity in humans is associated with poor outcomes across the reproductive spectrum. Emerging evidence indicates that...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Han L, Wang H, Li L, Li X, Ge J, Reiter RJ, Wang Q . Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2 dependent pathway. J Pineal Res. 2017 Jun 28. doi: 10.1111/jpi.12431. [Epub ahead of print].

In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression

Authors:
Garcia GR, Goodale BC, Wiley MW, La Du JK, Hendrix DA, Tanguay RL
Citation:
Mol Pharmacol. 2017 Jun; 91(6): 609-19. Published online 2017 Jun. doi: 10.1124/mol.117.108233
Epub:
Not Epub
Abstract:
Xenobiotic activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) prevents the proper...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Garcia GR, Goodale BC, Wiley MW, La Du JK, Hendrix DA, Tanguay RL. In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression. Mol Pharmacol. 2017 Jun; 91(6): 609-19. Published online 2017 Jun. doi: 10.1124/mol.117.108233.

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