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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus

Authors:
Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C, Clowes V, Vogt J, Turnpenny P, Williamson MP, Alembik Y; Clinical Sequencing Exploratory Research Study Consortium; Deciphering Developmental Disorders Consortium, Glasgow E, McNeill A
Citation:
PLoS Genet. 2017 Aug 31;13(8):e1006957. doi: 10.1371/journal.pgen.1006957. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Deletions at chromosome 2p25.3 are associated with a syndrome consisting of intellectual disability and obesity. The smallest...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006957
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C, Clowes V, Vogt J, Turnpenny P, Williamson MP, Alembik Y; Clinical Sequencing Exploratory Research Study Consortium; Deciphering Developmental Disorders Consortium, Glasgow E, McNeill A. MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. PLoS Genet. 2017 Aug 31;13(8):e1006957. doi: 10.1371/journal.pgen.1006957. [Epub ahead of print].

Functional validation of novel MKS3/TMEM67 mutations in COACH syndrome

Authors:
Lee S-H, Nam T-S, Li W, Kim JH, Yoon W, Choi Y-D, Kim K-H, Cai H, Kim MJ, Kim C, Choy HE, Kim N, Chay KO, Kim M-K, Choi S-Y
Citation:
Sci Rep. 2017;7:10222. doi:10.1038/s41598-017-10652-z
Epub:
Not Epub
Abstract:
COACH syndrome is an autosomal recessive developmental disorder, a subtype of Joubert syndrome and related disorders,...
Link:
https://www.nature.com/articles/s41598-017-10652-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee S-H, Nam T-S, Li W, Kim JH, Yoon W, Choi Y-D, Kim K-H, Cai H, Kim MJ, Kim C, Choy HE, Kim N, Chay KO, Kim M-K, Choi S-Y. Functional validation of novel MKS3/TMEM67 mutations in COACH syndrome. Sci Rep. 2017;7:10222. doi:10.1038/s41598-017-10652-z.

RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo

Authors:
Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE
Citation:
Neuron. 2017 Aug 16;95(4):852-868.e8. doi: 10.1016/j.neuron.2017.07.016. Epub 2017 Aug 3
Epub:
Not Epub
Abstract:
Nascent proteins can be positioned rapidly at precise subcellular locations by local protein synthesis (LPS) to facilitate...
Link:
http://www.cell.com/neuron/fulltext/S0896-6273(17)30638-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE. RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo. Neuron. 2017 Aug 16;95(4):852-868.e8. doi: 10.1016/j.neuron.2017.07.016. Epub 2017 Aug 3.

Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos

Authors:
Mellott DO, Thisdelle J, Burke RD
Citation:
Development. 2017 Aug 29. pii: dev.151720. doi: 10.1242/dev.151720. [Epub ahead of print]
Epub:
Yes
Abstract:
We have examined regulation of neurogenesis by Delta/Notch signaling in sea urchin embryos. At gastrulation neural progenitors...
Link:
http://dev.biologists.org/content/early/2017/08/29/dev.151720
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Mellott DO, Thisdelle J, Burke RD. Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos. Development. 2017 Aug 29. pii: dev.151720. doi: 10.1242/dev.151720. [Epub ahead of print].

Dysfunction of the MDM2/p53 axis is linked to premature aging

Authors:
Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah MK, Saha B, Hisama FM, Rading K, Goebel I, Schütz P, Speit G, Högel J, Thiele H, Nürnberg G, Nürnberg P, Hammerschmidt M, Zhu Y, Tong DR, Katz C, Martin GM, Oshima J, Prives C, Kubisch C
Citation:
J Clin Invest. 2017 Aug 28. pii: 92171. doi: 10.1172/JCI92171. [Epub ahead of print]
Epub:
Yes
Abstract:
The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin...
Link:
https://www.jci.org/articles/view/92171
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah MK, Saha B, Hisama FM, Rading K, Goebel I, Schütz P, Speit G, Högel J, Thiele H, Nürnberg G, Nürnberg P, Hammerschmidt M, Zhu Y, Tong DR, Katz C, Martin GM, Oshima J, Prives C, Kubisch C. Dysfunction of the MDM2/p53 axis is linked to premature aging. J Clin Invest. 2017 Aug 28. pii: 92171. doi: 10.1172/JCI92171. [Epub ahead of print].

NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

Authors:
Prince LR, Prosseda SD, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P, Renshaw SA, Whyte MKB, Sabroe I
Citation:
Blood. 2017 Aug 24;130(8):1014-1025. doi: 10.1182/blood-2017-03-770164. Epub 2017 Jun 21
Epub:
Not Epub
Abstract:
The lifespan of neutrophils is plastic and highly responsive to factors that regulate cellular survival. Defects in neutrophil...
Link:
http://www.bloodjournal.org/content/130/8/1014
Organism or Cell Type:
zebrafish
Citation Extract:
Prince LR, Prosseda SD, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P, Renshaw SA, Whyte MKB, Sabroe I. NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood. 2017 Aug 24;130(8):1014-1025. doi: 10.1182/blood-2017-03-770164. Epub 2017 Jun 21.

Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization

Authors:
Vettori A, Greenald D, Wilson GK, Peron M, Facchinello N, Markham E, Sinnakaruppan M, Matthews LC, McKeating JA, Argenton F, van Eeden FJM
Citation:
PNAS USA. 2017;[Epub ahead of print] doi:10.1073/pnas.1705338114
Epub:
Yes
Abstract:
Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue homeostasis and regulate the cellular...
Link:
http://www.pnas.org/content/early/2017/08/28/1705338114.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vettori A, Greenald D, Wilson GK, Peron M, Facchinello N, Markham E, Sinnakaruppan M, Matthews LC, McKeating JA, Argenton F, van Eeden FJM. Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization. PNAS USA. 2017;[Epub ahead of print] doi:10.1073/pnas.1705338114.

The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching

Authors:
Hildebrand S, Hultin S, Subramani A, Petropoulos S, Zhang Y, Cao X, Mpindi J, Kalloniemi O, Johansson S, Majumdar A, Lanner F, Holmgren L
Citation:
Sci Rep. 2017 Aug 25;7(1):9540. doi: 10.1038/s41598-017-10102-w
Epub:
Not Epub
Abstract:
Epithelial cells connect via cell-cell junctions to form sheets of cells with separate cellular compartments. These cellular...
Link:
https://www.nature.com/articles/s41598-017-10102-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hildebrand S, Hultin S, Subramani A, Petropoulos S, Zhang Y, Cao X, Mpindi J, Kalloniemi O, Johansson S, Majumdar A, Lanner F, Holmgren L. The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Sci Rep. 2017 Aug 25;7(1):9540. doi: 10.1038/s41598-017-10102-w.

Delayed APC/C activation extends the first mitosis of mouse embryos

Authors:
Ajduk A, Strauss B, Pines J, Zernicka-Goetz M
Citation:
Sci Rep. 2017;7:9682. doi:10.1038/s41598-017-09526-1
Epub:
Not Epub
Abstract:
The correct temporal regulation of mitosis underpins genomic stability because it ensures the alignment of chromosomes on the...
Link:
https://www.nature.com/articles/s41598-017-09526-1
Delivery Method:
microinjection
Organism or Cell Type:
mouse embryo
Citation Extract:
Ajduk A, Strauss B, Pines J, Zernicka-Goetz M. Delayed APC/C activation extends the first mitosis of mouse embryos. Sci Rep. 2017;7:9682. doi:10.1038/s41598-017-09526-1.

Novel Heparin Receptor Transmembrane Protein 184a Regulates Angiogenesis in the Adult Zebrafish Caudal Fin

Authors:
Farwell SLN, Reylander KG, Iovine MK, Lowe-Krentz LJ
Citation:
Front Physiol. 2017;[Epub ahead of print] doi:doi: 10.3389/fphys.2017.00671
Epub:
Yes
Abstract:
Transmembrane protein 184A (TMEM184A) was recently identified as the heparin receptor in vascular cells. Heparin binds...
Link:
http://journal.frontiersin.org/article/10.3389/fphys.2017.00671/abstract
Organism or Cell Type:
zebrafish
Citation Extract:
Farwell SLN, Reylander KG, Iovine MK, Lowe-Krentz LJ. Novel Heparin Receptor Transmembrane Protein 184a Regulates Angiogenesis in the Adult Zebrafish Caudal Fin. Front Physiol. 2017;[Epub ahead of print] doi:doi: 10.3389/fphys.2017.00671.

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